YBR192W / RIM2

Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR192W / RIM2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.63|P-value:2.23E-7 ID:SGTC_16|Compound:erodoxin|FD-Score:3.63|P-value:5.52E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:3.96|P-value:1.84E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.62|P-value:5.63E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:14.40|P-value:2.44E-38 ID:SGTC_70|Compound:0141-0289|FD-Score:7.60|P-value:5.10E-12 ID:SGTC_119|Compound:0121-0043|FD-Score:3.87|P-value:2.48E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:11.90|P-value:7.62E-27 ID:SGTC_124|Compound:0136-0217|FD-Score:5.93|P-value:5.32E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:3.74|P-value:3.84E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.53|P-value:7.49E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:5.28|P-value:1.09E-6 ID:SGTC_186|Compound:3455-3465|FD-Score:4.14|P-value:1.00E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:5.23|P-value:1.36E-6 ID:SGTC_203|Compound:k066-0004|FD-Score:5.65|P-value:2.05E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:10.90|P-value:1.40E-22 ID:SGTC_288|Compound:1315-0019|FD-Score:9.95|P-value:3.03E-19 ID:SGTC_331|Compound:k048-0133|FD-Score:3.81|P-value:3.04E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.80|P-value:3.13E-4 ID:SGTC_393|Compound:acivicin|FD-Score:6.57|P-value:2.01E-9 ID:SGTC_396|Compound:dithiazanine|FD-Score:4.21|P-value:7.74E-5 ID:SGTC_444|Compound:curcumin|FD-Score:5.31|P-value:9.49E-7 ID:SGTC_520|Compound:3584-0023|FD-Score:6.40|P-value:5.03E-9 ID:SGTC_525|Compound:k781-2675|FD-Score:6.55|P-value:2.21E-9 ID:SGTC_553|Compound:k007-0256|FD-Score:5.82|P-value:9.18E-8 ID:SGTC_576|Compound:1073-0113|FD-Score:6.48|P-value:3.14E-9 ID:SGTC_601|Compound:0986-0029|FD-Score:14.00|P-value:3.70E-36 ID:SGTC_602|Compound:3130-1533|FD-Score:11.70|P-value:9.95E-26 ID:SGTC_623|Compound:k072-0108|FD-Score:13.30|P-value:1.30E-32 ID:SGTC_660|Compound:4031-1742|FD-Score:3.58|P-value:6.36E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.16|P-value:9.21E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.60|P-value:7.60E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:-3.66|P-value:6.28E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:5.39|P-value:6.71E-7 ID:SGTC_730|Compound:1436-0052|FD-Score:15.10|P-value:9.37E-42 ID:SGTC_745|Compound:0469-0705|FD-Score:10.10|P-value:7.76E-20 ID:SGTC_788|Compound:1182-0090|FD-Score:5.04|P-value:3.06E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:3.90|P-value:2.30E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:4.38|P-value:4.09E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:10.20|P-value:3.33E-20 ID:SGTC_848|Compound:0368-0089|FD-Score:7.22|P-value:5.20E-11 ID:SGTC_851|Compound:0394-0702|FD-Score:8.86|P-value:1.19E-15 ID:SGTC_895|Compound:0964-0006|FD-Score:5.00|P-value:3.57E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:6.16|P-value:1.71E-8 ID:SGTC_908|Compound:3448-7491|FD-Score:6.92|P-value:2.87E-10 ID:SGTC_969|Compound:1313-0238|FD-Score:3.52|P-value:7.75E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:5.30|P-value:1.01E-6 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.67|P-value:1.86E-7 ID:SGTC_1057|Compound:3448-5381|FD-Score:5.38|P-value:7.02E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:11.60|P-value:1.90E-25 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.27|P-value:6.29E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.18|P-value:1.15E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:14.80|P-value:6.42E-40 ID:SGTC_1171|Compound:0368-0077|FD-Score:5.56|P-value:3.12E-7 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.32|P-value:5.14E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.78|P-value:3.36E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:5.01|P-value:3.54E-6 ID:SGTC_1288|Compound:0973-0013|FD-Score:4.52|P-value:2.51E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:7.46|P-value:1.22E-11 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.49|P-value:2.73E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:7.81|P-value:1.35E-12 ID:SGTC_1315|Compound:1237-0019|FD-Score:7.03|P-value:1.58E-10 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.02|P-value:1.51E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.91|P-value:2.21E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:4.05|P-value:1.36E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:11.60|P-value:2.27E-25 ID:SGTC_1438|Compound:4092-1045|FD-Score:-3.74|P-value:4.89E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:6.95|P-value:2.40E-10 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.75|P-value:3.73E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:6.88|P-value:3.59E-10 ID:SGTC_1556|Compound:plumbagin|FD-Score:6.26|P-value:1.02E-8 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.63|P-value:5.40E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-4.33|P-value:6.54E-5 ID:SGTC_1614|Compound:st002383|FD-Score:3.62|P-value:5.69E-4 ID:SGTC_1620|Compound:st003704|FD-Score:5.06|P-value:2.82E-6 ID:SGTC_1621|Compound:st003705|FD-Score:4.67|P-value:1.39E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.55|P-value:7.02E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.74|P-value:1.05E-5 ID:SGTC_1793|Compound:st048256|FD-Score:4.59|P-value:1.89E-5 ID:SGTC_1815|Compound:st051655|FD-Score:10.30|P-value:1.19E-20 ID:SGTC_1831|Compound:st055328|FD-Score:11.20|P-value:8.49E-24 ID:SGTC_1914|Compound:st062367|FD-Score:-4.63|P-value:2.16E-5 ID:SGTC_1917|Compound:st066507|FD-Score:6.98|P-value:2.07E-10 ID:SGTC_1935|Compound:st074532|FD-Score:5.29|P-value:1.06E-6 ID:SGTC_1952|Compound:st077036|FD-Score:5.72|P-value:1.49E-7 ID:SGTC_1962|Compound:st076595|FD-Score:4.50|P-value:2.69E-5 ID:SGTC_2066|Compound:5222451|FD-Score:6.45|P-value:3.71E-9 ID:SGTC_2102|Compound:5377816|FD-Score:4.45|P-value:3.23E-5 ID:SGTC_2108|Compound:5365811|FD-Score:6.22|P-value:1.25E-8 ID:SGTC_2112|Compound:5488546|FD-Score:4.73|P-value:1.07E-5 ID:SGTC_2124|Compound:5246320|FD-Score:15.50|P-value:9.02E-44 ID:SGTC_2139|Compound:5578692|FD-Score:8.52|P-value:1.26E-14 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.78|P-value:9.01E-6 ID:SGTC_2183|Compound:6420625|FD-Score:3.67|P-value:4.74E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.79|P-value:3.26E-4 ID:SGTC_2225|Compound:6654152|FD-Score:5.71|P-value:1.55E-7 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:4.03|P-value:1.46E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:14.90|P-value:2.01E-40 ID:SGTC_2251|Compound:lansoprazole|FD-Score:12.10|P-value:1.47E-27 ID:SGTC_2329|Compound:6138490|FD-Score:3.44|P-value:9.90E-4 ID:SGTC_2336|Compound:9001819|FD-Score:6.60|P-value:1.67E-9 ID:SGTC_2344|Compound:7990960|FD-Score:9.50|P-value:1.00E-17 ID:SGTC_2408|Compound:sulbentine|FD-Score:7.58|P-value:5.79E-12 ID:SGTC_2430|Compound:5571206|FD-Score:6.11|P-value:2.23E-8 ID:SGTC_2449|Compound:5812982|FD-Score:4.39|P-value:4.03E-5 ID:SGTC_2459|Compound:5811157|FD-Score:14.20|P-value:4.65E-37 ID:SGTC_2471|Compound:5466956|FD-Score:10.50|P-value:2.15E-21 ID:SGTC_2475|Compound:5812728|FD-Score:17.60|P-value:5.49E-56 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:5.29|P-value:1.04E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.49|P-value:2.80E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.58|P-value:6.34E-4 ID:SGTC_2585|Compound:alliin|FD-Score:4.92|P-value:5.10E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.90|P-value:5.57E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:7.60|P-value:5.17E-12 ID:SGTC_2659|Compound:sanguinarine|FD-Score:9.51|P-value:9.04E-18 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.98|P-value:1.71E-4 ID:SGTC_2696|Compound:st077691|FD-Score:4.48|P-value:2.84E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.52|P-value:7.64E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.54|P-value:2.27E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.52|P-value:7.75E-4 ID:SGTC_2799|Compound:7812892|FD-Score:5.23|P-value:1.38E-6 ID:SGTC_2827|Compound:7993847|FD-Score:3.63|P-value:5.51E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.67|P-value:4.74E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.55|P-value:8.77E-4 ID:SGTC_2928|Compound:9011484|FD-Score:6.34|P-value:6.84E-9 ID:SGTC_2930|Compound:9013230|FD-Score:13.60|P-value:2.28E-34 ID:SGTC_2941|Compound:9056145|FD-Score:3.76|P-value:3.61E-4 ID:SGTC_2943|Compound:9068529|FD-Score:8.47|P-value:1.78E-14 ID:SGTC_2968|Compound:9090663|FD-Score:3.89|P-value:2.36E-4 ID:SGTC_2980|Compound:9014342|FD-Score:7.59|P-value:5.60E-12 ID:SGTC_3004|Compound:9076122|FD-Score:3.73|P-value:3.96E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.90|P-value:2.25E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.70|P-value:4.41E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.52|P-value:9.57E-4 ID:SGTC_3118|Compound:9124250|FD-Score:3.87|P-value:2.51E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.08|P-value:1.20E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.87|P-value:2.52E-4 ID:SGTC_3161|Compound:9100388|FD-Score:4.30|P-value:5.69E-5 ID:SGTC_3181|Compound:9108277|FD-Score:10.10|P-value:7.25E-20 ID:SGTC_3219|Compound:9131112|FD-Score:4.07|P-value:1.27E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.37|P-value:4.29E-5 ID:SGTC_3303|Compound:9125618|FD-Score:4.14|P-value:9.87E-5 ID:SGTC_3338|Compound:9144300|FD-Score:3.87|P-value:2.51E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.63|P-value:2.23E-7 ID:SGTC_16|Compound:erodoxin|FD-Score:3.63|P-value:5.52E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:3.96|P-value:1.84E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.62|P-value:5.63E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:14.40|P-value:2.44E-38 ID:SGTC_70|Compound:0141-0289|FD-Score:7.60|P-value:5.10E-12 ID:SGTC_119|Compound:0121-0043|FD-Score:3.87|P-value:2.48E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:11.90|P-value:7.62E-27 ID:SGTC_124|Compound:0136-0217|FD-Score:5.93|P-value:5.32E-8 ID:SGTC_143|Compound:4032-1194|FD-Score:3.74|P-value:3.84E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.53|P-value:7.49E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:5.28|P-value:1.09E-6 ID:SGTC_186|Compound:3455-3465|FD-Score:4.14|P-value:1.00E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:5.23|P-value:1.36E-6 ID:SGTC_203|Compound:k066-0004|FD-Score:5.65|P-value:2.05E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:10.90|P-value:1.40E-22 ID:SGTC_288|Compound:1315-0019|FD-Score:9.95|P-value:3.03E-19 ID:SGTC_331|Compound:k048-0133|FD-Score:3.81|P-value:3.04E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.80|P-value:3.13E-4 ID:SGTC_393|Compound:acivicin|FD-Score:6.57|P-value:2.01E-9 ID:SGTC_396|Compound:dithiazanine|FD-Score:4.21|P-value:7.74E-5 ID:SGTC_444|Compound:curcumin|FD-Score:5.31|P-value:9.49E-7 ID:SGTC_520|Compound:3584-0023|FD-Score:6.40|P-value:5.03E-9 ID:SGTC_525|Compound:k781-2675|FD-Score:6.55|P-value:2.21E-9 ID:SGTC_553|Compound:k007-0256|FD-Score:5.82|P-value:9.18E-8 ID:SGTC_576|Compound:1073-0113|FD-Score:6.48|P-value:3.14E-9 ID:SGTC_601|Compound:0986-0029|FD-Score:14.00|P-value:3.70E-36 ID:SGTC_602|Compound:3130-1533|FD-Score:11.70|P-value:9.95E-26 ID:SGTC_623|Compound:k072-0108|FD-Score:13.30|P-value:1.30E-32 ID:SGTC_660|Compound:4031-1742|FD-Score:3.58|P-value:6.36E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.16|P-value:9.21E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.60|P-value:7.60E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:-3.66|P-value:6.28E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:5.39|P-value:6.71E-7 ID:SGTC_730|Compound:1436-0052|FD-Score:15.10|P-value:9.37E-42 ID:SGTC_745|Compound:0469-0705|FD-Score:10.10|P-value:7.76E-20 ID:SGTC_788|Compound:1182-0090|FD-Score:5.04|P-value:3.06E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:3.90|P-value:2.30E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:4.38|P-value:4.09E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:10.20|P-value:3.33E-20 ID:SGTC_848|Compound:0368-0089|FD-Score:7.22|P-value:5.20E-11 ID:SGTC_851|Compound:0394-0702|FD-Score:8.86|P-value:1.19E-15 ID:SGTC_895|Compound:0964-0006|FD-Score:5.00|P-value:3.57E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:6.16|P-value:1.71E-8 ID:SGTC_908|Compound:3448-7491|FD-Score:6.92|P-value:2.87E-10 ID:SGTC_969|Compound:1313-0238|FD-Score:3.52|P-value:7.75E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:5.30|P-value:1.01E-6 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.67|P-value:1.86E-7 ID:SGTC_1057|Compound:3448-5381|FD-Score:5.38|P-value:7.02E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:11.60|P-value:1.90E-25 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.27|P-value:6.29E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.18|P-value:1.15E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:14.80|P-value:6.42E-40 ID:SGTC_1171|Compound:0368-0077|FD-Score:5.56|P-value:3.12E-7 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.32|P-value:5.14E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.78|P-value:3.36E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:5.01|P-value:3.54E-6 ID:SGTC_1288|Compound:0973-0013|FD-Score:4.52|P-value:2.51E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:7.46|P-value:1.22E-11 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.49|P-value:2.73E-5 ID:SGTC_1311|Compound:1190-0148|FD-Score:7.81|P-value:1.35E-12 ID:SGTC_1315|Compound:1237-0019|FD-Score:7.03|P-value:1.58E-10 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.02|P-value:1.51E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.91|P-value:2.21E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:4.05|P-value:1.36E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:11.60|P-value:2.27E-25 ID:SGTC_1438|Compound:4092-1045|FD-Score:-3.74|P-value:4.89E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:6.95|P-value:2.40E-10 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.75|P-value:3.73E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:6.88|P-value:3.59E-10 ID:SGTC_1556|Compound:plumbagin|FD-Score:6.26|P-value:1.02E-8 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.63|P-value:5.40E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-4.33|P-value:6.54E-5 ID:SGTC_1614|Compound:st002383|FD-Score:3.62|P-value:5.69E-4 ID:SGTC_1620|Compound:st003704|FD-Score:5.06|P-value:2.82E-6 ID:SGTC_1621|Compound:st003705|FD-Score:4.67|P-value:1.39E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.55|P-value:7.02E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.74|P-value:1.05E-5 ID:SGTC_1793|Compound:st048256|FD-Score:4.59|P-value:1.89E-5 ID:SGTC_1815|Compound:st051655|FD-Score:10.30|P-value:1.19E-20 ID:SGTC_1831|Compound:st055328|FD-Score:11.20|P-value:8.49E-24 ID:SGTC_1914|Compound:st062367|FD-Score:-4.63|P-value:2.16E-5 ID:SGTC_1917|Compound:st066507|FD-Score:6.98|P-value:2.07E-10 ID:SGTC_1935|Compound:st074532|FD-Score:5.29|P-value:1.06E-6 ID:SGTC_1952|Compound:st077036|FD-Score:5.72|P-value:1.49E-7 ID:SGTC_1962|Compound:st076595|FD-Score:4.50|P-value:2.69E-5 ID:SGTC_2066|Compound:5222451|FD-Score:6.45|P-value:3.71E-9 ID:SGTC_2102|Compound:5377816|FD-Score:4.45|P-value:3.23E-5 ID:SGTC_2108|Compound:5365811|FD-Score:6.22|P-value:1.25E-8 ID:SGTC_2112|Compound:5488546|FD-Score:4.73|P-value:1.07E-5 ID:SGTC_2124|Compound:5246320|FD-Score:15.50|P-value:9.02E-44 ID:SGTC_2139|Compound:5578692|FD-Score:8.52|P-value:1.26E-14 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.78|P-value:9.01E-6 ID:SGTC_2183|Compound:6420625|FD-Score:3.67|P-value:4.74E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.79|P-value:3.26E-4 ID:SGTC_2225|Compound:6654152|FD-Score:5.71|P-value:1.55E-7 ID:SGTC_2230|Compound:bromochlorosalicylanilide|FD-Score:4.03|P-value:1.46E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:14.90|P-value:2.01E-40 ID:SGTC_2251|Compound:lansoprazole|FD-Score:12.10|P-value:1.47E-27 ID:SGTC_2329|Compound:6138490|FD-Score:3.44|P-value:9.90E-4 ID:SGTC_2336|Compound:9001819|FD-Score:6.60|P-value:1.67E-9 ID:SGTC_2344|Compound:7990960|FD-Score:9.50|P-value:1.00E-17 ID:SGTC_2408|Compound:sulbentine|FD-Score:7.58|P-value:5.79E-12 ID:SGTC_2430|Compound:5571206|FD-Score:6.11|P-value:2.23E-8 ID:SGTC_2449|Compound:5812982|FD-Score:4.39|P-value:4.03E-5 ID:SGTC_2459|Compound:5811157|FD-Score:14.20|P-value:4.65E-37 ID:SGTC_2471|Compound:5466956|FD-Score:10.50|P-value:2.15E-21 ID:SGTC_2475|Compound:5812728|FD-Score:17.60|P-value:5.49E-56 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:5.29|P-value:1.04E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.49|P-value:2.80E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.58|P-value:6.34E-4 ID:SGTC_2585|Compound:alliin|FD-Score:4.92|P-value:5.10E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.90|P-value:5.57E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:7.60|P-value:5.17E-12 ID:SGTC_2659|Compound:sanguinarine|FD-Score:9.51|P-value:9.04E-18 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.98|P-value:1.71E-4 ID:SGTC_2696|Compound:st077691|FD-Score:4.48|P-value:2.84E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.52|P-value:7.64E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:4.54|P-value:2.27E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.52|P-value:7.75E-4 ID:SGTC_2799|Compound:7812892|FD-Score:5.23|P-value:1.38E-6 ID:SGTC_2827|Compound:7993847|FD-Score:3.63|P-value:5.51E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.67|P-value:4.74E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.55|P-value:8.77E-4 ID:SGTC_2928|Compound:9011484|FD-Score:6.34|P-value:6.84E-9 ID:SGTC_2930|Compound:9013230|FD-Score:13.60|P-value:2.28E-34 ID:SGTC_2941|Compound:9056145|FD-Score:3.76|P-value:3.61E-4 ID:SGTC_2943|Compound:9068529|FD-Score:8.47|P-value:1.78E-14 ID:SGTC_2968|Compound:9090663|FD-Score:3.89|P-value:2.36E-4 ID:SGTC_2980|Compound:9014342|FD-Score:7.59|P-value:5.60E-12 ID:SGTC_3004|Compound:9076122|FD-Score:3.73|P-value:3.96E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.90|P-value:2.25E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.70|P-value:4.41E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.52|P-value:9.57E-4 ID:SGTC_3118|Compound:9124250|FD-Score:3.87|P-value:2.51E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.08|P-value:1.20E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.87|P-value:2.52E-4 ID:SGTC_3161|Compound:9100388|FD-Score:4.30|P-value:5.69E-5 ID:SGTC_3181|Compound:9108277|FD-Score:10.10|P-value:7.25E-20 ID:SGTC_3219|Compound:9131112|FD-Score:4.07|P-value:1.27E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.37|P-value:4.29E-5 ID:SGTC_3303|Compound:9125618|FD-Score:4.14|P-value:9.87E-5 ID:SGTC_3338|Compound:9144300|FD-Score:3.87|P-value:2.51E-4

Top fitness defect scores for YBR192W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2475 5812728 17.60 15.0 µM 5.49E-56 mitochondrial processes 3 9.38E-70 6.70
2 SGTC_2124 5246320 15.50 200.0 µM 9.02E-44 heme biosynthesis & mitochondrial translocase 2 2.13E-54 2.35
3 SGTC_730 1436-0052 15.10 41.2 µM 9.37E-42 mitochondrial processes 2 7.28E-52 6.09
4 SGTC_2233 sulbentine 14.90 40.4 µM 2.01E-40 3 3.42E-50 0.04
5 SGTC_1113 artemisinin 14.80 1.2 µM 6.42E-40 heme biosynthesis & mitochondrial translocase 2 1.47E-49 4.38
6 SGTC_63 0099-0242 14.40 26.7 µM 2.44E-38 mitochondrial stress 2 1.42E-47 4.30
7 SGTC_2459 5811157 14.20 9.2 µM 4.65E-37 mitochondrial processes 3 5.77E-46 3.98
8 SGTC_601 0986-0029 14.00 62.9 µM 3.70E-36 calcium & mitochondrial duress 2 7.82E-45 2.72
9 SGTC_2930 9013230 13.60 14.9 µM 2.28E-34 heme biosynthesis & mitochondrial translocase 2 1.39E-42 0.78
10 SGTC_623 k072-0108 13.30 16.9 µM 1.30E-32 heme biosynthesis & mitochondrial translocase 2 2.23E-40 1.68
11 SGTC_2251 lansoprazole 12.10 556.0 µM 1.47E-27 1 4.89E-34 7.90
12 SGTC_123 0083-0120 11.90 66.7 µM 7.62E-27 1 3.86E-33 2.79
13 SGTC_602 3130-1533 11.70 38.1 µM 9.95E-26 1 9.71E-32 2.82
14 SGTC_1098 clofazimine 11.60 15.1 µM 1.90E-25 heme biosynthesis & mitochondrial translocase 3 2.18E-31 1.59
15 SGTC_1422 4031-0024 11.60 15.5 µM 2.27E-25 iron homeostasis 1 2.73E-31 2.84
16 SGTC_1831 st055328 11.20 12.0 µM 8.49E-24 heme biosynthesis & mitochondrial translocase 2 2.57E-29 2.94
17 SGTC_208 k072-0098 10.90 12.4 µM 1.40E-22 heme biosynthesis & mitochondrial translocase 5 8.66E-28 2.20
18 SGTC_2471 5466956 10.50 24.8 µM 2.15E-21 mitochondrial processes 5 2.66E-26 0.65
19 SGTC_1815 st051655 10.30 58.2 µM 1.19E-20 TSC3-RPN4 1 2.26E-25 2.37
20 SGTC_842 0271-0008 10.20 11.1 µM 3.33E-20 heme biosynthesis & mitochondrial translocase 3 8.25E-25 2.88

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.441 7.54E-160 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.438 2.06E-157 YKL195W MIA40 het Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.395 1.02E-125 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.355 2.24E-100 YMR113W FOL3 het Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
0.320 1.41E-80 YBL105C PKC1 het Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.314 1.81E-77 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.312 7.49E-77 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.295 2.37E-68 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.278 2.88E-60 YJL031C BET4 het Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.264 2.33E-54 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.252 1.20E-49 YLR355C ILV5 het Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
0.245 4.55E-47 YML091C RPM2 het Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
0.244 9.36E-47 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.222 7.79E-39 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.215 2.19E-36 YDR427W RPN9 het Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress