YBR197C

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR197C / YBR197C

Click on Significant Values for Screen Details

Top fitness defect scores for YBR197C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_188 3229-0966 7.97 278.5 µM 4.11E-16 5 7.78E-16
2 SGTC_996 3970-0799 5.99 1.8 µM 7.58E-10 35 1.07E-9
3 SGTC_1854 st056233 5.73 32.9 µM 3.60E-9 amide catabolism 4 4.94E-9
4 SGTC_8 0354-0001 5.27 70.0 µM 5.35E-8 36 6.95E-8
5 SGTC_46 0329-0187a 5.22 2.2 µM 7.06E-8 36 9.12E-8
6 SGTC_129 0088-0017 5.02 176.6 µM 2.01E-7 47 2.54E-7
7 SGTC_696 1560-0013 4.77 611.0 µM 7.37E-7 12 9.10E-7
8 SGTC_213 1246-0773 4.53 967.0 nM 2.43E-6 14 2.93E-6
9 SGTC_697 0508-1955 4.51 564.0 µM 2.68E-6 23 3.23E-6
10 SGTC_56 0957-0365 4.17 83.2 µM 1.30E-5 Golgi 42 1.52E-5
11 SGTC_140 0062-0056 4.07 502.5 µM 1.99E-5 20 2.30E-5
12 SGTC_1984 st072354 4.07 53.1 µM 1.99E-5 14 2.30E-5
13 SGTC_568 1193-0097 4.06 7.5 µM 2.14E-5 ERAD & cell cycle 142 2.48E-5
14 SGTC_1257 0669-0121 3.94 16.0 µM 3.48E-5 28 4.00E-5
15 SGTC_1750 st081859 3.91 2.4 µM 3.98E-5 endomembrane recycling 189 4.56E-5
16 SGTC_87 0100-0052 3.83 35.5 µM 5.69E-5 118 6.48E-5
17 SGTC_955 1216-0110 3.81 33.0 µM 6.15E-5 sphingolipid biosynthesis & PDR1 71 6.99E-5
18 SGTC_1778 st046819 3.77 58.9 µM 7.25E-5 31 8.21E-5
19 SGTC_2966 9084041 3.61 48.0 µM 1.39E-4 44 1.56E-4
20 SGTC_1324 1418-0026 3.56 34.4 µM 1.69E-4 22 1.88E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.281 1.02E-61 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.249 1.56E-48 YPR153W YPR153W hom Putative protein of unknown function
0.230 2.41E-41 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.211 5.68E-35 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.208 2.94E-34 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.183 1.11E-26 YDL051W LHP1 hom RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
0.166 3.13E-22 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.165 9.32E-22 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.155 2.09E-19 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.146 1.44E-17 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.146 1.50E-17 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.144 6.03E-17 YOL075C_p YOL075C_p hom Putative ABC transporter
0.138 1.11E-15 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.127 1.35E-13 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.125 3.38E-13 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance