YBR213W / MET8

Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR213W / MET8

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:-3.10|P-value:9.69E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.30|P-value:5.05E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-4.68|P-value:1.71E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.60|P-value:1.70E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.19|P-value:7.37E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.14|P-value:8.59E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.73|P-value:1.59E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:-3.20|P-value:7.13E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.50|P-value:3.61E-4 ID:SGTC_446|Compound:go6976|FD-Score:-3.55|P-value:2.03E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.26|P-value:8.35E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.24|P-value:9.06E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.95|P-value:6.69E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.24|P-value:8.92E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.25|P-value:8.56E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.45|P-value:4.29E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.93|P-value:7.18E-5 ID:SGTC_1613|Compound:st002381|FD-Score:4.38|P-value:1.12E-5 ID:SGTC_2334|Compound:9017922|FD-Score:3.22|P-value:9.62E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.32|P-value:1.41E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.32|P-value:6.72E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.64|P-value:3.40E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:5.06|P-value:4.58E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:-4.44|P-value:5.08E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.58|P-value:1.79E-4 ID:SGTC_2855|Compound:9016525|FD-Score:4.84|P-value:1.34E-6 ID:SGTC_2858|Compound:9025781|FD-Score:3.23|P-value:9.14E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.48|P-value:2.64E-4 ID:SGTC_2972|Compound:9093619|FD-Score:5.00|P-value:6.08E-7 ID:SGTC_2973|Compound:9094665|FD-Score:-3.13|P-value:8.86E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-3.62|P-value:1.55E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.29|P-value:7.65E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.32|P-value:6.80E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.11|P-value:9.39E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-3.10|P-value:9.69E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.30|P-value:5.05E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-4.68|P-value:1.71E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.60|P-value:1.70E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.19|P-value:7.37E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.14|P-value:8.59E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.73|P-value:1.59E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:-3.20|P-value:7.13E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.50|P-value:3.61E-4 ID:SGTC_446|Compound:go6976|FD-Score:-3.55|P-value:2.03E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.26|P-value:8.35E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.24|P-value:9.06E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.95|P-value:6.69E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.24|P-value:8.92E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.25|P-value:8.56E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.45|P-value:4.29E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.93|P-value:7.18E-5 ID:SGTC_1613|Compound:st002381|FD-Score:4.38|P-value:1.12E-5 ID:SGTC_2334|Compound:9017922|FD-Score:3.22|P-value:9.62E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.32|P-value:1.41E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.32|P-value:6.72E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.64|P-value:3.40E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:5.06|P-value:4.58E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:-4.44|P-value:5.08E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.58|P-value:1.79E-4 ID:SGTC_2855|Compound:9016525|FD-Score:4.84|P-value:1.34E-6 ID:SGTC_2858|Compound:9025781|FD-Score:3.23|P-value:9.14E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.48|P-value:2.64E-4 ID:SGTC_2972|Compound:9093619|FD-Score:5.00|P-value:6.08E-7 ID:SGTC_2973|Compound:9094665|FD-Score:-3.13|P-value:8.86E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-3.62|P-value:1.55E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.29|P-value:7.65E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.32|P-value:6.80E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.11|P-value:9.39E-4

Top fitness defect scores for YBR213W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2635 hydroquinidine 5.06 100.0 µM 4.58E-7 7 2.09E-7
2 SGTC_2972 9093619 5.00 59.9 µM 6.08E-7 6 2.82E-7
3 SGTC_2855 9016525 4.84 58.4 µM 1.34E-6 8 6.44E-7
4 SGTC_2607 solasodine 4.64 47.4 µM 3.40E-6 40 1.72E-6
5 SGTC_1613 st002381 4.38 52.1 µM 1.12E-5 16 5.97E-6
6 SGTC_2450 5739737 4.32 12.9 µM 1.41E-5 16 7.65E-6
7 SGTC_998 3996-0085 3.95 177.0 µM 6.69E-5 19 3.91E-5
8 SGTC_1588 farnesol 3.93 29.9 µM 7.18E-5 9 4.21E-5
9 SGTC_213 1246-0773 3.73 967.0 nM 1.59E-4 28 9.70E-5
10 SGTC_378 3970-0959 3.50 8.3 µM 3.61E-4 27 2.30E-4
11 SGTC_1444 4112-3581 3.45 28.0 µM 4.29E-4 23 2.76E-4
12 SGTC_2561 acetosyringone 3.32 100.0 µM 6.72E-4 53 4.43E-4
13 SGTC_3268 9137683 3.32 49.5 µM 6.80E-4 20 4.48E-4
14 SGTC_3147 9097027 3.29 49.5 µM 7.65E-4 49 5.07E-4
15 SGTC_572 0960-0087 3.26 17.7 µM 8.35E-4 59 5.56E-4
16 SGTC_1215 3852-0577 3.25 11.2 µM 8.56E-4 35 5.71E-4
17 SGTC_1154 4088-0362 3.24 150.0 µM 8.92E-4 53 5.96E-4
18 SGTC_885 0865-0106 3.24 16.8 µM 9.06E-4 TSC3-RPN4 53 6.06E-4
19 SGTC_2858 9025781 3.23 9.0 µM 9.14E-4 sphingolipid biosynthesis & PDR1 144 6.12E-4
20 SGTC_2334 9017922 3.22 200.0 µM 9.62E-4 43 6.46E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 6.59E-10 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.105 1.26E-9 YOR119C RIO1 het Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
0.103 2.46E-9 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.097 1.64E-8 YHR148W IMP3 het Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
0.096 2.93E-8 YGR168C_p YGR168C_p hom Putative protein of unknown function; YGR168C is not an essential gene
0.090 1.94E-7 YDL043C PRP11 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.088 3.64E-7 YLR125W_p YLR125W_p hom Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
0.087 3.97E-7 YLR143W DPH6 hom Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene
0.087 4.08E-7 YCL049C_p YCL049C_p hom Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene
0.083 1.59E-6 YDR100W TVP15 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
0.083 1.73E-6 YJL122W ALB1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
0.083 1.74E-6 YBR094W PBY1 hom Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress
0.081 2.36E-6 YJL214W HXT8 hom Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
0.080 4.06E-6 YIL166C_p YIL166C_p hom Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
0.079 4.83E-6 YBR219C_p YBR219C_p hom Putative protein of unknown function; YBR219C is not an essential gene