YBR220C_p

Putative protein of unknown function; YBR220C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR220C / YBR220C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.25|P-value:5.83E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:3.08|P-value:7.58E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.18|P-value:5.32E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.18|P-value:4.56E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.28|P-value:3.61E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.85|P-value:2.84E-7 ID:SGTC_435|Compound:c-PAF|FD-Score:3.28|P-value:3.65E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.12|P-value:6.47E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:4.26|P-value:5.58E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:3.67|P-value:7.91E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.09|P-value:1.23E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.06|P-value:8.13E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.06|P-value:8.19E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.14|P-value:9.95E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.06|P-value:6.91E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.74|P-value:5.86E-5 ID:SGTC_1893|Compound:st059353|FD-Score:4.11|P-value:1.13E-5 ID:SGTC_2258|Compound:7960471|FD-Score:3.19|P-value:5.03E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.29|P-value:3.00E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.37|P-value:2.57E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.26|P-value:3.90E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-3.16|P-value:4.86E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.42|P-value:2.60E-6 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.04|P-value:8.76E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:6.75|P-value:1.54E-12 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:-3.10|P-value:6.00E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.00|P-value:8.68E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.03|P-value:7.86E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.18|P-value:5.27E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.99|P-value:1.94E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.87|P-value:3.24E-5 ID:SGTC_2935|Compound:9038016|FD-Score:-3.52|P-value:1.22E-4 ID:SGTC_2962|Compound:9082311|FD-Score:5.12|P-value:6.20E-8 ID:SGTC_3077|Compound:9117319|FD-Score:-2.97|P-value:9.67E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-3.82|P-value:3.41E-5 ID:SGTC_3275|Compound:9138069|FD-Score:3.35|P-value:2.80E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.25|P-value:5.83E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:3.08|P-value:7.58E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.18|P-value:5.32E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.18|P-value:4.56E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.28|P-value:3.61E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.85|P-value:2.84E-7 ID:SGTC_435|Compound:c-PAF|FD-Score:3.28|P-value:3.65E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.12|P-value:6.47E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:4.26|P-value:5.58E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:3.67|P-value:7.91E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:4.09|P-value:1.23E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.06|P-value:8.13E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.06|P-value:8.19E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.14|P-value:9.95E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.06|P-value:6.91E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.74|P-value:5.86E-5 ID:SGTC_1893|Compound:st059353|FD-Score:4.11|P-value:1.13E-5 ID:SGTC_2258|Compound:7960471|FD-Score:3.19|P-value:5.03E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.29|P-value:3.00E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.37|P-value:2.57E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.26|P-value:3.90E-4 ID:SGTC_2585|Compound:alliin|FD-Score:-3.16|P-value:4.86E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.42|P-value:2.60E-6 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.04|P-value:8.76E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:6.75|P-value:1.54E-12 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:-3.10|P-value:6.00E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-3.00|P-value:8.68E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.03|P-value:7.86E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.18|P-value:5.27E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.99|P-value:1.94E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.87|P-value:3.24E-5 ID:SGTC_2935|Compound:9038016|FD-Score:-3.52|P-value:1.22E-4 ID:SGTC_2962|Compound:9082311|FD-Score:5.12|P-value:6.20E-8 ID:SGTC_3077|Compound:9117319|FD-Score:-2.97|P-value:9.67E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-3.82|P-value:3.41E-5 ID:SGTC_3275|Compound:9138069|FD-Score:3.35|P-value:2.80E-4

Top fitness defect scores for YBR220C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2634 4'-methoxyflavone 6.75 100.0 µM 1.54E-12 4 7.48E-12
2 SGTC_2962 9082311 5.12 13.2 µM 6.20E-8 6 1.52E-7
3 SGTC_379 3970-0972 4.85 5.9 µM 2.84E-7 tubulin folding & SWR complex 15 6.31E-7
4 SGTC_2607 solasodine 4.42 47.4 µM 2.60E-6 45 5.03E-6
5 SGTC_761 k216-0224 4.26 480.0 µM 5.58E-6 13 1.03E-5
6 SGTC_6 0844-0013 4.25 19.8 µM 5.83E-6 67 1.07E-5
7 SGTC_1361 1608-0041 4.14 5.6 µM 9.95E-6 RPP1 & pyrimidine depletion 15 1.77E-5
8 SGTC_1893 st059353 4.11 36.1 µM 1.13E-5 21 1.99E-5
9 SGTC_1030 k029-0042 4.09 36.7 µM 1.23E-5 TSC3-RPN4 24 2.16E-5
10 SGTC_2795 7780010 3.99 54.5 µM 1.94E-5 27 3.30E-5
11 SGTC_2930 9013230 3.87 14.9 µM 3.24E-5 heme biosynthesis & mitochondrial translocase 41 5.34E-5
12 SGTC_1735 st034310 3.74 56.8 µM 5.86E-5 Golgi 34 9.33E-5
13 SGTC_965 1291-5240 3.67 308.0 µM 7.91E-5 39 1.24E-4
14 SGTC_2394 5221648 3.37 200.0 µM 2.57E-4 45 3.74E-4
15 SGTC_3275 9138069 3.35 49.5 µM 2.80E-4 15 4.06E-4
16 SGTC_256 clotrimazole 3.28 625.0 nM 3.61E-4 ergosterol depletion effects on membrane 54 5.15E-4
17 SGTC_435 c-PAF 3.28 6.7 µM 3.65E-4 77 5.20E-4
18 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.26 3.7 µM 3.90E-4 154 5.53E-4
19 SGTC_2258 7960471 3.19 200.0 µM 5.03E-4 32 7.03E-4
20 SGTC_2772 vinpocetine 3.18 57.1 µM 5.27E-4 52 7.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.210 1.25E-34 YGL086W MAD1 hom Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
0.136 3.16E-15 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.130 4.94E-14 YLR329W REC102 hom Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
0.122 1.12E-12 YHR043C DOG2 hom 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, paralogous to DOG1, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed
0.122 1.61E-12 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.119 4.17E-12 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.119 5.55E-12 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.117 8.95E-12 YMR031C EIS1 hom Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.109 2.31E-10 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.108 3.84E-10 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.107 4.90E-10 YDR390C UBA2 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.106 6.56E-10 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.105 1.05E-9 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.103 2.01E-9 YLR186W EMG1 het Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity
0.103 2.07E-9 YML113W DAT1 hom DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability