YBR244W / GPX2

Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR244W / GPX2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:9.90|P-value:1.12E-25 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.03|P-value:8.93E-6 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.00|P-value:6.49E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.27|P-value:2.37E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.15|P-value:4.94E-6 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.96|P-value:2.68E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:4.10|P-value:6.29E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:3.01|P-value:6.18E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.12|P-value:4.24E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:2.93|P-value:8.38E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.29|P-value:4.16E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.65|P-value:5.03E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.21|P-value:2.98E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.11|P-value:4.32E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.62|P-value:5.71E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.40|P-value:1.46E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.49|P-value:9.69E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:2.97|P-value:7.25E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.39|P-value:1.51E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.84|P-value:2.10E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:-3.67|P-value:9.10E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.62|P-value:5.66E-5 ID:SGTC_1691|Compound:st019933|FD-Score:4.21|P-value:3.87E-6 ID:SGTC_1702|Compound:st027038|FD-Score:3.36|P-value:1.67E-4 ID:SGTC_1714|Compound:st033236|FD-Score:2.96|P-value:7.62E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.50|P-value:1.81E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.04|P-value:5.58E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.55|P-value:7.47E-5 ID:SGTC_1864|Compound:st057645|FD-Score:-3.05|P-value:9.91E-4 ID:SGTC_1887|Compound:st057648|FD-Score:-3.16|P-value:6.75E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.28|P-value:2.24E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-4.21|P-value:8.45E-6 ID:SGTC_2058|Compound:5236698|FD-Score:-3.33|P-value:3.59E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.08|P-value:4.93E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.10|P-value:8.22E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.55|P-value:7.50E-5 ID:SGTC_2387|Compound:9077560|FD-Score:4.13|P-value:5.54E-6 ID:SGTC_2456|Compound:5770359|FD-Score:2.91|P-value:8.90E-4 ID:SGTC_2485|Compound:5633444|FD-Score:2.97|P-value:7.27E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.35|P-value:3.34E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.83|P-value:2.92E-13 ID:SGTC_3337|Compound:9144342|FD-Score:-3.30|P-value:3.93E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:9.90|P-value:1.12E-25 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.03|P-value:8.93E-6 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.00|P-value:6.49E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.27|P-value:2.37E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.15|P-value:4.94E-6 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.96|P-value:2.68E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:4.10|P-value:6.29E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:3.01|P-value:6.18E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.12|P-value:4.24E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:2.93|P-value:8.38E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-3.29|P-value:4.16E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:3.65|P-value:5.03E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.21|P-value:2.98E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.11|P-value:4.32E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.62|P-value:5.71E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.40|P-value:1.46E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.49|P-value:9.69E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:2.97|P-value:7.25E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.39|P-value:1.51E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.84|P-value:2.10E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:-3.67|P-value:9.10E-5 ID:SGTC_1611|Compound:st001856|FD-Score:3.62|P-value:5.66E-5 ID:SGTC_1691|Compound:st019933|FD-Score:4.21|P-value:3.87E-6 ID:SGTC_1702|Compound:st027038|FD-Score:3.36|P-value:1.67E-4 ID:SGTC_1714|Compound:st033236|FD-Score:2.96|P-value:7.62E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.50|P-value:1.81E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.04|P-value:5.58E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.55|P-value:7.47E-5 ID:SGTC_1864|Compound:st057645|FD-Score:-3.05|P-value:9.91E-4 ID:SGTC_1887|Compound:st057648|FD-Score:-3.16|P-value:6.75E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.28|P-value:2.24E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-4.21|P-value:8.45E-6 ID:SGTC_2058|Compound:5236698|FD-Score:-3.33|P-value:3.59E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.08|P-value:4.93E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.10|P-value:8.22E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.55|P-value:7.50E-5 ID:SGTC_2387|Compound:9077560|FD-Score:4.13|P-value:5.54E-6 ID:SGTC_2456|Compound:5770359|FD-Score:2.91|P-value:8.90E-4 ID:SGTC_2485|Compound:5633444|FD-Score:2.97|P-value:7.27E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.35|P-value:3.34E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:6.83|P-value:2.92E-13 ID:SGTC_3337|Compound:9144342|FD-Score:-3.30|P-value:3.93E-4

Top fitness defect scores for YBR244W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 9.90 9.0 µM 1.12E-25 cell wall 78 2.09E-23
2 SGTC_2567 aureobasidin a 6.83 60.0 nM 2.92E-13 30 4.39E-12
3 SGTC_1099 5-nonyloxytryptamine 4.40 2.9 µM 1.46E-6 12 5.39E-6
4 SGTC_1369 1866-0067 4.39 208.0 µM 1.51E-6 RPP1 & pyrimidine depletion 28 5.56E-6
5 SGTC_1691 st019933 4.21 84.6 µM 3.87E-6 9 1.30E-5
6 SGTC_266 formosanin C 4.15 406.0 nM 4.94E-6 sphingolipid biosynthesis & PDR1 63 1.63E-5
7 SGTC_2387 9077560 4.13 195.1 µM 5.54E-6 13 1.81E-5
8 SGTC_598 3937-0236 4.10 20.2 µM 6.29E-6 ERG2 21 2.02E-5
9 SGTC_238 5hr heat shock (37°C) + nsc-638432 4.03 8.9 µM 8.93E-6 heat shock/prefoldin 39 2.78E-5
10 SGTC_1374 2889-5571 3.84 141.0 µM 2.10E-5 RSC complex & mRNA processing 43 6.04E-5
11 SGTC_1000 4048-0884 3.65 8.7 µM 5.03E-5 copper-dependent oxidative stress 39 1.33E-4
12 SGTC_1611 st001856 3.62 99.4 µM 5.66E-5 23 1.48E-4
13 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 3.62 15.5 µM 5.71E-5 37 1.49E-4
14 SGTC_1746 st038117 3.55 42.0 µM 7.47E-5 45 1.90E-4
15 SGTC_2384 9036245 3.55 200.0 µM 7.50E-5 44 1.91E-4
16 SGTC_1107 amlodipine 3.49 47.0 µM 9.69E-5 57 2.41E-4
17 SGTC_1702 st027038 3.36 51.0 µM 1.67E-4 30 3.94E-4
18 SGTC_1908 st060353 3.28 56.5 µM 2.24E-4 RPP1 & pyrimidine depletion 69 5.14E-4
19 SGTC_251 melphalan 3.27 456.5 µM 2.37E-4 DNA damage response 53 5.42E-4
20 SGTC_1052 3253-3998 3.21 198.0 µM 2.98E-4 48 6.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.289 1.12E-65 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.280 1.26E-61 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.273 2.53E-58 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.264 8.98E-55 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.251 1.97E-49 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.239 8.73E-45 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.236 1.30E-43 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.228 7.95E-41 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.219 1.35E-37 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.213 1.05E-35 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.211 3.17E-35 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.206 1.85E-33 YNL289W PCL1 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth
0.203 1.52E-32 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.203 1.57E-32 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.200 1.44E-31 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress