YBR252W / DUT1

deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR252W / DUT1

Click on Significant Values for Screen Details ID:SGTC_109|Compound:0132-0036|FD-Score:3.27|P-value:6.09E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.32|P-value:5.19E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.83|P-value:7.43E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.39|P-value:2.83E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:4.26|P-value:1.17E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:7.13|P-value:5.94E-13 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.35|P-value:3.26E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.53|P-value:2.36E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.24|P-value:4.81E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:5.59|P-value:1.35E-8 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.50|P-value:3.92E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:4.00|P-value:3.58E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:3.87|P-value:6.22E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.47|P-value:2.10E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.21|P-value:1.50E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:3.70|P-value:1.22E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.65|P-value:1.92E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:3.53|P-value:2.36E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:4.18|P-value:1.70E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:3.74|P-value:1.07E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:4.63|P-value:2.08E-6 ID:SGTC_982|Compound:1491-0518|FD-Score:3.62|P-value:1.67E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:-3.04|P-value:9.66E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.13|P-value:9.99E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.35|P-value:8.03E-6 ID:SGTC_1751|Compound:st044839|FD-Score:-3.10|P-value:8.02E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.16|P-value:9.03E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.37|P-value:4.27E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.96|P-value:4.37E-5 ID:SGTC_2093|Compound:5331342|FD-Score:-3.56|P-value:1.48E-4 ID:SGTC_2154|Compound:5570129|FD-Score:4.33|P-value:8.64E-6 ID:SGTC_2164|Compound:5685496|FD-Score:3.31|P-value:5.31E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.27|P-value:6.19E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.49|P-value:2.78E-4 ID:SGTC_2331|Compound:7980721|FD-Score:6.16|P-value:4.31E-10 ID:SGTC_2334|Compound:9017922|FD-Score:-4.03|P-value:2.12E-5 ID:SGTC_2461|Compound:5755302|FD-Score:3.41|P-value:3.63E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:5.26|P-value:8.62E-8 ID:SGTC_2665|Compound:lovastatin|FD-Score:5.26|P-value:8.60E-8 ID:SGTC_2698|Compound:st077697|FD-Score:-3.15|P-value:6.64E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.74|P-value:5.67E-9 ID:SGTC_2819|Compound:7996655|FD-Score:4.36|P-value:7.45E-6 ID:SGTC_2823|Compound:7987624|FD-Score:4.15|P-value:1.89E-5 ID:SGTC_2844|Compound:9010103|FD-Score:4.30|P-value:9.75E-6 ID:SGTC_2883|Compound:9059145|FD-Score:4.30|P-value:9.77E-6 ID:SGTC_2921|Compound:7974240|FD-Score:-3.34|P-value:3.40E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.23|P-value:7.08E-4 ID:SGTC_2951|Compound:9072950|FD-Score:6.37|P-value:1.11E-10 ID:SGTC_3126|Compound:9127922|FD-Score:3.79|P-value:8.72E-5 ID:SGTC_3132|Compound:9126706|FD-Score:-3.91|P-value:3.61E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.42|P-value:3.51E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.40|P-value:3.84E-4 ID:SGTC_3262|Compound:9137218|FD-Score:3.33|P-value:5.00E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.74|P-value:7.32E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-4.32|P-value:5.94E-6 ID:SGTC_3265|Compound:9137266|FD-Score:6.15|P-value:4.60E-10 ID:SGTC_3268|Compound:9137683|FD-Score:6.33|P-value:1.42E-10 ID:SGTC_3270|Compound:9137563|FD-Score:-3.83|P-value:4.97E-5 ID:SGTC_3280|Compound:9140961|FD-Score:5.96|P-value:1.48E-9 ID:SGTC_109|Compound:0132-0036|FD-Score:3.27|P-value:6.09E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.32|P-value:5.19E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:3.83|P-value:7.43E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.39|P-value:2.83E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:4.26|P-value:1.17E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:7.13|P-value:5.94E-13 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.35|P-value:3.26E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.53|P-value:2.36E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.24|P-value:4.81E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:5.59|P-value:1.35E-8 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.50|P-value:3.92E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:4.00|P-value:3.58E-5 ID:SGTC_569|Compound:4130-2812|FD-Score:3.87|P-value:6.22E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.47|P-value:2.10E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.21|P-value:1.50E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:3.70|P-value:1.22E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.65|P-value:1.92E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:3.53|P-value:2.36E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:4.18|P-value:1.70E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:3.74|P-value:1.07E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:4.63|P-value:2.08E-6 ID:SGTC_982|Compound:1491-0518|FD-Score:3.62|P-value:1.67E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:-3.04|P-value:9.66E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.13|P-value:9.99E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.35|P-value:8.03E-6 ID:SGTC_1751|Compound:st044839|FD-Score:-3.10|P-value:8.02E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.16|P-value:9.03E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.37|P-value:4.27E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.96|P-value:4.37E-5 ID:SGTC_2093|Compound:5331342|FD-Score:-3.56|P-value:1.48E-4 ID:SGTC_2154|Compound:5570129|FD-Score:4.33|P-value:8.64E-6 ID:SGTC_2164|Compound:5685496|FD-Score:3.31|P-value:5.31E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.27|P-value:6.19E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.49|P-value:2.78E-4 ID:SGTC_2331|Compound:7980721|FD-Score:6.16|P-value:4.31E-10 ID:SGTC_2334|Compound:9017922|FD-Score:-4.03|P-value:2.12E-5 ID:SGTC_2461|Compound:5755302|FD-Score:3.41|P-value:3.63E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:5.26|P-value:8.62E-8 ID:SGTC_2665|Compound:lovastatin|FD-Score:5.26|P-value:8.60E-8 ID:SGTC_2698|Compound:st077697|FD-Score:-3.15|P-value:6.64E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.74|P-value:5.67E-9 ID:SGTC_2819|Compound:7996655|FD-Score:4.36|P-value:7.45E-6 ID:SGTC_2823|Compound:7987624|FD-Score:4.15|P-value:1.89E-5 ID:SGTC_2844|Compound:9010103|FD-Score:4.30|P-value:9.75E-6 ID:SGTC_2883|Compound:9059145|FD-Score:4.30|P-value:9.77E-6 ID:SGTC_2921|Compound:7974240|FD-Score:-3.34|P-value:3.40E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.23|P-value:7.08E-4 ID:SGTC_2951|Compound:9072950|FD-Score:6.37|P-value:1.11E-10 ID:SGTC_3126|Compound:9127922|FD-Score:3.79|P-value:8.72E-5 ID:SGTC_3132|Compound:9126706|FD-Score:-3.91|P-value:3.61E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.42|P-value:3.51E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.40|P-value:3.84E-4 ID:SGTC_3262|Compound:9137218|FD-Score:3.33|P-value:5.00E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.74|P-value:7.32E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-4.32|P-value:5.94E-6 ID:SGTC_3265|Compound:9137266|FD-Score:6.15|P-value:4.60E-10 ID:SGTC_3268|Compound:9137683|FD-Score:6.33|P-value:1.42E-10 ID:SGTC_3270|Compound:9137563|FD-Score:-3.83|P-value:4.97E-5 ID:SGTC_3280|Compound:9140961|FD-Score:5.96|P-value:1.48E-9

Top fitness defect scores for YBR252W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_245 methotrexate 7.13 289.6 µM 5.94E-13 5 5.06E-13 0.51
2 SGTC_2951 9072950 6.37 58.1 µM 1.11E-10 ERG2 1 9.42E-11 1.52
3 SGTC_3268 9137683 6.33 49.5 µM 1.42E-10 1 1.21E-10 1.24
4 SGTC_2331 7980721 6.16 200.0 µM 4.31E-10 4 3.68E-10 0.41
5 SGTC_3265 9137266 6.15 49.5 µM 4.60E-10 1 3.92E-10 1.12
6 SGTC_3280 9140961 5.96 49.5 µM 1.48E-9 60S ribosome export 3 1.26E-9 1.50
7 SGTC_2779 methotrexate 5.74 400.0 µM 5.67E-9 5 4.84E-9 0.11
8 SGTC_385 1494-0393 5.59 12.4 µM 1.35E-8 1 1.15E-8 1.11
9 SGTC_2665 lovastatin 5.26 100.0 µM 8.60E-8 1 7.37E-8 1.47
10 SGTC_2663 amphotericin b 5.26 100.0 µM 8.62E-8 2 7.38E-8 0.81
11 SGTC_679 0422-0091 4.65 41.4 µM 1.92E-6 Golgi 7 1.65E-6 0.12
12 SGTC_913 3487-1245 4.63 167.0 µM 2.08E-6 8 1.80E-6 0.09
13 SGTC_387 norethindrone acetate 4.50 66.7 µM 3.92E-6 3 3.39E-6 0.74
14 SGTC_2819 7996655 4.36 46.4 µM 7.45E-6 2 6.45E-6 0.43
15 SGTC_1717 st033143 4.35 58.0 µM 8.03E-6 4 6.95E-6 0.34
16 SGTC_2154 5570129 4.33 200.0 µM 8.64E-6 1 7.48E-6 0.52
17 SGTC_2844 9010103 4.30 26.0 µM 9.75E-6 6 8.45E-6 0.12
18 SGTC_2883 9059145 4.30 45.5 µM 9.77E-6 3 8.46E-6 0.24
19 SGTC_194 1486-1323 4.26 56.9 µM 1.17E-5 7 1.01E-5 0.39
20 SGTC_575 k072-0246 4.21 11.9 µM 1.50E-5 5 1.30E-5 0.31

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 1.13E-40 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.173 6.62E-24 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.171 2.26E-23 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.114 3.87E-11 YER056C FCY2 hom Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress
0.094 4.78E-8 YLR385C SWC7 hom Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin
0.092 9.22E-8 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.090 1.53E-7 YPL195W APL5 hom Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function
0.087 4.19E-7 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.084 1.17E-6 YCL052C PBN1 het Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X
0.080 3.07E-6 YJR090C GRR1 hom F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification
0.080 3.58E-6 YNL261W ORC5 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.079 4.26E-6 YDL030W PRP9 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
0.079 4.27E-6 YDR079C-A TFB5 hom Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair
0.078 6.86E-6 YGL238W CSE1 het Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
0.077 8.38E-6 YMR272W-B_p YMR272W-B_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching