YBR258C / SHG1

Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR258C / SHG1

Click on Significant Values for Screen Details ID:SGTC_80|Compound:0159-0065|FD-Score:3.07|P-value:4.28E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:2.85|P-value:9.77E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:2.96|P-value:6.60E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.33|P-value:1.21E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:2.90|P-value:8.19E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.99|P-value:7.15E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:2.88|P-value:8.89E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.72|P-value:2.58E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.41|P-value:8.63E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:4.10|P-value:4.06E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.64|P-value:3.04E-5 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.61|P-value:4.40E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.38|P-value:1.20E-4 ID:SGTC_1725|Compound:st036284|FD-Score:2.99|P-value:5.80E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-3.09|P-value:3.35E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.18|P-value:2.69E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.50|P-value:7.19E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.50|P-value:7.20E-5 ID:SGTC_2358|Compound:9037157|FD-Score:9.52|P-value:1.30E-25 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.83|P-value:8.92E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.04|P-value:4.78E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.16|P-value:2.46E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-2.85|P-value:8.37E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.12|P-value:3.66E-6 ID:SGTC_2829|Compound:7992743|FD-Score:3.72|P-value:2.55E-5 ID:SGTC_2831|Compound:7999036|FD-Score:5.72|P-value:2.33E-10 ID:SGTC_2839|Compound:9003951|FD-Score:3.27|P-value:1.92E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.43|P-value:9.82E-5 ID:SGTC_2843|Compound:9000894|FD-Score:3.37|P-value:1.24E-4 ID:SGTC_2847|Compound:9005661|FD-Score:3.43|P-value:9.80E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-3.54|P-value:4.91E-5 ID:SGTC_3205|Compound:9113483|FD-Score:3.05|P-value:4.61E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.98|P-value:5.12E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:3.07|P-value:4.28E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:2.85|P-value:9.77E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:2.96|P-value:6.60E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.33|P-value:1.21E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:2.90|P-value:8.19E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.99|P-value:7.15E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:2.88|P-value:8.89E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.72|P-value:2.58E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.41|P-value:8.63E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:4.10|P-value:4.06E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.64|P-value:3.04E-5 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.61|P-value:4.40E-5 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.38|P-value:1.20E-4 ID:SGTC_1725|Compound:st036284|FD-Score:2.99|P-value:5.80E-4 ID:SGTC_2059|Compound:5238311|FD-Score:-3.09|P-value:3.35E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.18|P-value:2.69E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.50|P-value:7.19E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.50|P-value:7.20E-5 ID:SGTC_2358|Compound:9037157|FD-Score:9.52|P-value:1.30E-25 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.83|P-value:8.92E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.04|P-value:4.78E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.16|P-value:2.46E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-2.85|P-value:8.37E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.12|P-value:3.66E-6 ID:SGTC_2829|Compound:7992743|FD-Score:3.72|P-value:2.55E-5 ID:SGTC_2831|Compound:7999036|FD-Score:5.72|P-value:2.33E-10 ID:SGTC_2839|Compound:9003951|FD-Score:3.27|P-value:1.92E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.43|P-value:9.82E-5 ID:SGTC_2843|Compound:9000894|FD-Score:3.37|P-value:1.24E-4 ID:SGTC_2847|Compound:9005661|FD-Score:3.43|P-value:9.80E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-3.54|P-value:4.91E-5 ID:SGTC_3205|Compound:9113483|FD-Score:3.05|P-value:4.61E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.98|P-value:5.12E-4

Top fitness defect scores for YBR258C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2358 9037157 9.52 4.0 µM 1.30E-25 2 8.42E-22
2 SGTC_2831 7999036 5.72 19.5 µM 2.33E-10 8 5.45E-9
3 SGTC_2693 st077581 4.12 40.7 µM 3.66E-6 31 1.89E-5
4 SGTC_619 1652-1634 4.10 108.0 µM 4.06E-6 PDR1 18 2.06E-5
5 SGTC_431 k089-0097 3.99 107.0 µM 7.15E-6 iron homeostasis 41 3.34E-5
6 SGTC_2829 7992743 3.72 58.4 µM 2.55E-5 45 9.79E-5
7 SGTC_459 nigericin 3.72 15.3 µM 2.58E-5 69 9.90E-5
8 SGTC_1200 1643-0193 3.61 18.4 µM 4.40E-5 27 1.55E-4
9 SGTC_2130 NSC 7 3.50 2.5 µM 7.19E-5 copper-dependent oxidative stress 51 2.36E-4
10 SGTC_2309 7664088 3.50 163.9 µM 7.20E-5 63 2.36E-4
11 SGTC_2847 9005661 3.43 71.4 µM 9.80E-5 14 3.07E-4
12 SGTC_2840 9008771 3.43 71.4 µM 9.82E-5 17 3.07E-4
13 SGTC_1261 0712-0010 3.38 12.7 µM 1.20E-4 RNA processing & uracil transport 44 3.65E-4
14 SGTC_2843 9000894 3.37 45.5 µM 1.24E-4 16 3.75E-4
15 SGTC_2839 9003951 3.27 26.0 µM 1.92E-4 34 5.44E-4
16 SGTC_2129 girgensonine 3.18 121.0 µM 2.69E-4 heme biosynthesis & mitochondrial translocase 71 7.24E-4
17 SGTC_80 0159-0065 3.07 512.2 µM 4.28E-4 17 0.00107
18 SGTC_3205 9113483 3.05 49.5 µM 4.61E-4 82 0.00114
19 SGTC_2444 5485484 3.04 36.4 µM 4.78E-4 78 0.00118
20 SGTC_1725 st036284 2.99 20.6 µM 5.80E-4 72 0.00139

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.199 3.41E-31 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.191 6.62E-29 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.173 6.93E-24 YJR083C ACF4 hom Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
0.157 7.48E-20 YOL053W AIM39 hom Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
0.153 4.21E-19 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.153 5.61E-19 YNR026C SEC12 het Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER
0.151 1.32E-18 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.150 1.98E-18 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function
0.148 6.13E-18 YDR398W UTP5 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.148 7.16E-18 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.142 1.24E-16 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.141 2.41E-16 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.140 3.30E-16 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.140 3.76E-16 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.138 1.09E-15 YAL027W SAW1 hom 5'- and 3'-flap DNA binding protein; stimulates the endonuclease activity of Rad1/Rad10p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus