YBR260C / RGD1

GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR260C / RGD1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:11.90|P-value:4.03E-41 ID:SGTC_22|Compound:0964-0034|FD-Score:9.74|P-value:5.14E-28 ID:SGTC_40|Compound:0327-0103|FD-Score:3.10|P-value:2.68E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:23.00|P-value:2.90E-147 ID:SGTC_63|Compound:0099-0242|FD-Score:5.29|P-value:1.54E-9 ID:SGTC_122|Compound:0236-0016|FD-Score:3.28|P-value:1.23E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.87|P-value:2.51E-8 ID:SGTC_207|Compound:4185-0010|FD-Score:3.28|P-value:1.19E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:7.90|P-value:4.27E-19 ID:SGTC_315|Compound:k915-0449|FD-Score:3.68|P-value:1.89E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:2.98|P-value:4.36E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.61|P-value:2.69E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:-2.91|P-value:5.27E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.39|P-value:7.30E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:2.82|P-value:8.21E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:2.84|P-value:7.48E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.07|P-value:2.96E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:15.20|P-value:4.29E-65 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.30|P-value:1.03E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:6.29|P-value:9.52E-13 ID:SGTC_926|Compound:2268-1401|FD-Score:-2.84|P-value:7.05E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.55|P-value:3.39E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.43|P-value:5.76E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.26|P-value:1.26E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.89|P-value:6.13E-6 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.90|P-value:2.12E-8 ID:SGTC_1228|Compound:0124-0032|FD-Score:-2.97|P-value:4.16E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.04|P-value:3.41E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.34|P-value:9.47E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.77|P-value:4.54E-8 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.48|P-value:4.87E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.38|P-value:4.30E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.73|P-value:5.38E-8 ID:SGTC_1531|Compound:st059297|FD-Score:3.39|P-value:7.54E-5 ID:SGTC_1614|Compound:st002383|FD-Score:4.49|P-value:2.54E-7 ID:SGTC_1674|Compound:st016616|FD-Score:-2.99|P-value:3.86E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.45|P-value:5.59E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.42|P-value:6.12E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.25|P-value:1.39E-4 ID:SGTC_1864|Compound:st057645|FD-Score:-2.93|P-value:5.02E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.47|P-value:4.76E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.05|P-value:2.92E-6 ID:SGTC_1982|Compound:st072467|FD-Score:3.21|P-value:1.63E-4 ID:SGTC_2007|Compound:4011539|FD-Score:12.90|P-value:8.31E-48 ID:SGTC_2009|Compound:4012297|FD-Score:12.50|P-value:7.85E-45 ID:SGTC_2149|Compound:5554786|FD-Score:7.74|P-value:2.22E-18 ID:SGTC_2238|Compound:6671620|FD-Score:-5.71|P-value:6.99E-11 ID:SGTC_2239|Compound:6685329|FD-Score:3.47|P-value:5.07E-5 ID:SGTC_2272|Compound:7805186|FD-Score:6.65|P-value:4.78E-14 ID:SGTC_2286|Compound:7945697|FD-Score:3.78|P-value:1.16E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.62|P-value:1.13E-7 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.06|P-value:3.07E-4 ID:SGTC_2399|Compound:5884133|FD-Score:22.90|P-value:3.53E-145 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.11|P-value:2.52E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.31|P-value:1.01E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.23|P-value:2.23E-25 ID:SGTC_2584|Compound:androsterone|FD-Score:3.64|P-value:2.36E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.21|P-value:1.15E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.11|P-value:2.54E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.51|P-value:4.03E-5 ID:SGTC_2921|Compound:7974240|FD-Score:-3.33|P-value:9.10E-5 ID:SGTC_2936|Compound:9038235|FD-Score:-3.14|P-value:2.05E-4 ID:SGTC_2938|Compound:9059746|FD-Score:2.96|P-value:4.57E-4 ID:SGTC_3087|Compound:9117406|FD-Score:2.86|P-value:6.91E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.12|P-value:2.37E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:11.90|P-value:4.03E-41 ID:SGTC_22|Compound:0964-0034|FD-Score:9.74|P-value:5.14E-28 ID:SGTC_40|Compound:0327-0103|FD-Score:3.10|P-value:2.68E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:23.00|P-value:2.90E-147 ID:SGTC_63|Compound:0099-0242|FD-Score:5.29|P-value:1.54E-9 ID:SGTC_122|Compound:0236-0016|FD-Score:3.28|P-value:1.23E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.87|P-value:2.51E-8 ID:SGTC_207|Compound:4185-0010|FD-Score:3.28|P-value:1.19E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:7.90|P-value:4.27E-19 ID:SGTC_315|Compound:k915-0449|FD-Score:3.68|P-value:1.89E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:2.98|P-value:4.36E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.61|P-value:2.69E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:-2.91|P-value:5.27E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.39|P-value:7.30E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:2.82|P-value:8.21E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:2.84|P-value:7.48E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.07|P-value:2.96E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:15.20|P-value:4.29E-65 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.30|P-value:1.03E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:6.29|P-value:9.52E-13 ID:SGTC_926|Compound:2268-1401|FD-Score:-2.84|P-value:7.05E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.55|P-value:3.39E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.43|P-value:5.76E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.26|P-value:1.26E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.89|P-value:6.13E-6 ID:SGTC_1061|Compound:3448-9325|FD-Score:4.90|P-value:2.12E-8 ID:SGTC_1228|Compound:0124-0032|FD-Score:-2.97|P-value:4.16E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.04|P-value:3.41E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.34|P-value:9.47E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.77|P-value:4.54E-8 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.48|P-value:4.87E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.38|P-value:4.30E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.73|P-value:5.38E-8 ID:SGTC_1531|Compound:st059297|FD-Score:3.39|P-value:7.54E-5 ID:SGTC_1614|Compound:st002383|FD-Score:4.49|P-value:2.54E-7 ID:SGTC_1674|Compound:st016616|FD-Score:-2.99|P-value:3.86E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.45|P-value:5.59E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.42|P-value:6.12E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.25|P-value:1.39E-4 ID:SGTC_1864|Compound:st057645|FD-Score:-2.93|P-value:5.02E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.47|P-value:4.76E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.05|P-value:2.92E-6 ID:SGTC_1982|Compound:st072467|FD-Score:3.21|P-value:1.63E-4 ID:SGTC_2007|Compound:4011539|FD-Score:12.90|P-value:8.31E-48 ID:SGTC_2009|Compound:4012297|FD-Score:12.50|P-value:7.85E-45 ID:SGTC_2149|Compound:5554786|FD-Score:7.74|P-value:2.22E-18 ID:SGTC_2238|Compound:6671620|FD-Score:-5.71|P-value:6.99E-11 ID:SGTC_2239|Compound:6685329|FD-Score:3.47|P-value:5.07E-5 ID:SGTC_2272|Compound:7805186|FD-Score:6.65|P-value:4.78E-14 ID:SGTC_2286|Compound:7945697|FD-Score:3.78|P-value:1.16E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.62|P-value:1.13E-7 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.06|P-value:3.07E-4 ID:SGTC_2399|Compound:5884133|FD-Score:22.90|P-value:3.53E-145 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.11|P-value:2.52E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.31|P-value:1.01E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.23|P-value:2.23E-25 ID:SGTC_2584|Compound:androsterone|FD-Score:3.64|P-value:2.36E-5 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.21|P-value:1.15E-6 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.11|P-value:2.54E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.51|P-value:4.03E-5 ID:SGTC_2921|Compound:7974240|FD-Score:-3.33|P-value:9.10E-5 ID:SGTC_2936|Compound:9038235|FD-Score:-3.14|P-value:2.05E-4 ID:SGTC_2938|Compound:9059746|FD-Score:2.96|P-value:4.57E-4 ID:SGTC_3087|Compound:9117406|FD-Score:2.86|P-value:6.91E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.12|P-value:2.37E-4

Top fitness defect scores for YBR260C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 23.00 9.0 µM 2.90E-147 cell wall 5 1.15E-117
2 SGTC_2399 5884133 22.90 200.0 µM 3.53E-145 cell wall signaling 1 5.25E-116
3 SGTC_663 1486-0733 15.20 13.9 µM 4.29E-65 cell wall signaling 6 2.97E-52
4 SGTC_2007 4011539 12.90 71.8 µM 8.31E-48 cell wall signaling 8 1.75E-38
5 SGTC_2009 4012297 12.50 12.1 µM 7.85E-45 cell wall signaling 7 4.10E-36
6 SGTC_16 erodoxin 11.90 22.8 µM 4.03E-41 unfolded protein response 8 3.71E-33
7 SGTC_22 0964-0034 9.74 14.5 µM 5.14E-28 unfolded protein response 7 1.04E-22
8 SGTC_2582 agaric acid 9.23 100.0 µM 2.23E-25 redox potentiating 81 1.32E-20
9 SGTC_255 tunicamycin 7.90 200.5 nM 4.27E-19 unfolded protein response 18 1.36E-15
10 SGTC_2149 5554786 7.74 194.8 µM 2.22E-18 cell wall signaling 6 5.09E-15
11 SGTC_2272 7805186 6.65 180.0 µM 4.78E-14 cell wall signaling 5 1.48E-11
12 SGTC_916 4466-0038 6.29 42.0 nM 9.52E-13 cell wall 26 1.62E-10
13 SGTC_63 0099-0242 5.29 26.7 µM 1.54E-9 mitochondrial stress 47 5.99E-8
14 SGTC_1061 3448-9325 4.90 110.0 µM 2.12E-8 11 4.90E-7
15 SGTC_138 0850-0259 4.87 40.9 µM 2.51E-8 cell wall 148 5.62E-7
16 SGTC_1447 4239-0816 4.77 81.9 µM 4.54E-8 17 9.04E-7
17 SGTC_2289 7946404 4.62 165.1 µM 1.13E-7 71 1.88E-6
18 SGTC_1614 st002383 4.49 48.6 µM 2.54E-7 cell wall signaling 11 3.60E-6
19 SGTC_1874 staurosporine 4.05 7.6 µM 2.92E-6 cell wall signaling 24 2.57E-5
20 SGTC_2286 7945697 3.78 125.0 µM 1.16E-5 63 7.79E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.656 0 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.564 2.05E-281 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.491 3.91E-203 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.481 8.13E-194 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.464 3.97E-179 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.443 1.99E-161 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.417 3.06E-141 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.410 4.81E-136 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.401 6.60E-130 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.348 2.58E-96 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.315 3.10E-78 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.307 3.62E-74 YOR008C SLG1 hom Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
0.305 2.02E-73 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.300 6.91E-71 YAL058W CNE1 hom Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
0.290 4.17E-66 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids