YBR261C / TAE1

AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR261C / TAE1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-2.79|P-value:7.46E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.10|P-value:1.46E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-6.74|P-value:8.10E-15 ID:SGTC_77|Compound:0828-0286|FD-Score:-7.03|P-value:5.65E-16 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.20|P-value:1.32E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.01|P-value:3.05E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.56|P-value:2.42E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.08|P-value:2.21E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.09|P-value:2.19E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:2.97|P-value:3.45E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.50|P-value:3.17E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:2.94|P-value:3.88E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.40|P-value:5.29E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:-2.78|P-value:7.70E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-2.79|P-value:7.51E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:4.28|P-value:5.16E-7 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.44|P-value:2.67E-10 ID:SGTC_1191|Compound:1487-1166|FD-Score:6.01|P-value:3.40E-12 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.25|P-value:1.06E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.20|P-value:1.32E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.21|P-value:1.30E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.43|P-value:4.54E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.88|P-value:4.85E-6 ID:SGTC_1453|Compound:4237-0541|FD-Score:2.81|P-value:6.73E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.09|P-value:2.13E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:-2.83|P-value:6.29E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:-3.17|P-value:1.50E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.54|P-value:2.70E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:2.77|P-value:7.86E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.53|P-value:2.83E-5 ID:SGTC_1756|Compound:st041558|FD-Score:4.06|P-value:1.82E-6 ID:SGTC_1793|Compound:st048256|FD-Score:2.88|P-value:5.04E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.00|P-value:3.11E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.18|P-value:9.12E-7 ID:SGTC_2146|Compound:5545642|FD-Score:-2.98|P-value:3.43E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.36|P-value:6.52E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.27|P-value:9.41E-5 ID:SGTC_2432|Compound:5630864|FD-Score:3.75|P-value:9.13E-6 ID:SGTC_2435|Compound:5706476|FD-Score:4.13|P-value:1.26E-6 ID:SGTC_2570|Compound:licareol|FD-Score:-2.83|P-value:6.31E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.11|P-value:1.98E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.91|P-value:4.55E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:2.83|P-value:6.25E-4 ID:SGTC_2746|Compound:daunorubicin|FD-Score:2.80|P-value:6.85E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-2.85|P-value:5.88E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.41|P-value:5.08E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.40|P-value:5.41E-5 ID:SGTC_2987|Compound:9018338|FD-Score:-2.98|P-value:3.49E-4 ID:SGTC_3013|Compound:9080133|FD-Score:2.85|P-value:5.61E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-2.79|P-value:7.46E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.10|P-value:1.46E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-6.74|P-value:8.10E-15 ID:SGTC_77|Compound:0828-0286|FD-Score:-7.03|P-value:5.65E-16 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.20|P-value:1.32E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.01|P-value:3.05E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.56|P-value:2.42E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.08|P-value:2.21E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.09|P-value:2.19E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:2.97|P-value:3.45E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.50|P-value:3.17E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:2.94|P-value:3.88E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.40|P-value:5.29E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:-2.78|P-value:7.70E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-2.79|P-value:7.51E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:4.28|P-value:5.16E-7 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.44|P-value:2.67E-10 ID:SGTC_1191|Compound:1487-1166|FD-Score:6.01|P-value:3.40E-12 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.25|P-value:1.06E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.20|P-value:1.32E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.21|P-value:1.30E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.43|P-value:4.54E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.88|P-value:4.85E-6 ID:SGTC_1453|Compound:4237-0541|FD-Score:2.81|P-value:6.73E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.09|P-value:2.13E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:-2.83|P-value:6.29E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:-3.17|P-value:1.50E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.54|P-value:2.70E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:2.77|P-value:7.86E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.53|P-value:2.83E-5 ID:SGTC_1756|Compound:st041558|FD-Score:4.06|P-value:1.82E-6 ID:SGTC_1793|Compound:st048256|FD-Score:2.88|P-value:5.04E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.00|P-value:3.11E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.18|P-value:9.12E-7 ID:SGTC_2146|Compound:5545642|FD-Score:-2.98|P-value:3.43E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.36|P-value:6.52E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.27|P-value:9.41E-5 ID:SGTC_2432|Compound:5630864|FD-Score:3.75|P-value:9.13E-6 ID:SGTC_2435|Compound:5706476|FD-Score:4.13|P-value:1.26E-6 ID:SGTC_2570|Compound:licareol|FD-Score:-2.83|P-value:6.31E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.11|P-value:1.98E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.91|P-value:4.55E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:2.83|P-value:6.25E-4 ID:SGTC_2746|Compound:daunorubicin|FD-Score:2.80|P-value:6.85E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-2.85|P-value:5.88E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.41|P-value:5.08E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.40|P-value:5.41E-5 ID:SGTC_2987|Compound:9018338|FD-Score:-2.98|P-value:3.49E-4 ID:SGTC_3013|Compound:9080133|FD-Score:2.85|P-value:5.61E-4

Top fitness defect scores for YBR261C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1191 1487-1166 6.01 10.6 µM 3.40E-12 azole & statin 8 9.02E-10
2 SGTC_1083 didemethylchlorpromazine sulfoxide 5.44 707.4 nM 2.67E-10 redox potentiating 37 2.64E-8
3 SGTC_938 3126-1755 4.28 342.0 µM 5.16E-7 8 9.29E-6
4 SGTC_2126 5251174 4.18 33.9 µM 9.12E-7 23 1.45E-5
5 SGTC_2435 5706476 4.13 10.6 µM 1.26E-6 21 1.85E-5
6 SGTC_1756 st041558 4.06 35.5 µM 1.82E-6 11 2.47E-5
7 SGTC_1357 1503-1303 3.88 39.5 µM 4.85E-6 35 5.30E-5
8 SGTC_2432 5630864 3.75 12.2 µM 9.13E-6 26 8.67E-5
9 SGTC_394 menadione 3.56 8.3 µM 2.42E-5 superoxide 48 1.85E-4
10 SGTC_1753 st043925 3.53 64.0 µM 2.83E-5 14 2.09E-4
11 SGTC_702 1488-0190 3.50 94.0 µM 3.17E-5 amide catabolism 25 2.29E-4
12 SGTC_1333 1482-0047 3.43 286.0 µM 4.54E-5 27 3.03E-4
13 SGTC_2831 7999036 3.41 19.5 µM 5.08E-5 73 3.30E-4
14 SGTC_716 1683-5115 3.40 658.0 µM 5.29E-5 41 3.41E-4
15 SGTC_2430 5571206 3.27 200.0 µM 9.41E-5 88 5.34E-4
16 SGTC_1198 1612-1005 3.25 86.7 µM 1.06E-4 35 5.85E-4
17 SGTC_1208 2323-2347 3.20 50.3 µM 1.32E-4 30 6.97E-4
18 SGTC_457 grayanotoxin iii 3.08 135.0 µM 2.21E-4 136 0.00104
19 SGTC_1924 st058459 3.00 75.1 µM 3.11E-4 41 0.00136
20 SGTC_699 0375-0592 2.97 111.0 µM 3.45E-4 iron homeostasis 61 0.00147

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.218 2.60E-37 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.208 4.47E-34 YKR065C PAM17 hom Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
0.172 9.34E-24 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.163 2.25E-21 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.162 3.18E-21 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.150 2.61E-18 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.139 4.85E-16 YNL241C ZWF1 hom Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress
0.139 6.36E-16 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.138 8.22E-16 YCR060W TAH1 hom Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II
0.129 5.67E-14 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.116 1.52E-11 YGL149W_d YGL149W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
0.114 3.12E-11 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.113 4.53E-11 YBR147W RTC2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter
0.107 4.49E-10 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.106 6.89E-10 YGR033C TIM21 hom Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity