YBR272C / HSM3

Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR272C / HSM3

Click on Significant Values for Screen Details ID:SGTC_167|Compound:3672-0051|FD-Score:-3.39|P-value:1.64E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.08|P-value:5.37E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:3.18|P-value:3.83E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.07|P-value:5.82E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.06|P-value:8.39E-6 ID:SGTC_323|Compound:4013-0906|FD-Score:-3.08|P-value:5.44E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.33|P-value:2.14E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.20|P-value:3.39E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:5.24|P-value:1.43E-8 ID:SGTC_924|Compound:2046-0044|FD-Score:3.51|P-value:1.00E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.28|P-value:2.50E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-3.76|P-value:3.33E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.02|P-value:6.73E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.20|P-value:4.28E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.02|P-value:6.91E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.94|P-value:9.18E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.38|P-value:1.68E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.10|P-value:5.12E-4 ID:SGTC_1756|Compound:st041558|FD-Score:5.94|P-value:1.58E-10 ID:SGTC_1758|Compound:st042942|FD-Score:4.04|P-value:9.31E-6 ID:SGTC_1975|Compound:st070967|FD-Score:3.04|P-value:6.44E-4 ID:SGTC_2098|Compound:5376439|FD-Score:2.99|P-value:7.82E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.65|P-value:5.48E-5 ID:SGTC_2257|Compound:7960413|FD-Score:-3.89|P-value:1.82E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.29|P-value:2.49E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.53|P-value:8.91E-5 ID:SGTC_2432|Compound:5630864|FD-Score:3.25|P-value:2.90E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.47|P-value:1.21E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.47|P-value:1.16E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.38|P-value:1.67E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.19|P-value:3.59E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.44|P-value:4.16E-9 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.16|P-value:4.12E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.00|P-value:7.33E-4 ID:SGTC_2874|Compound:9043904|FD-Score:5.14|P-value:2.64E-8 ID:SGTC_2878|Compound:9043973|FD-Score:5.71|P-value:7.46E-10 ID:SGTC_2917|Compound:7979103|FD-Score:5.07|P-value:3.95E-8 ID:SGTC_2919|Compound:7978188|FD-Score:3.73|P-value:3.89E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-3.64|P-value:5.58E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-5.74|P-value:5.97E-10 ID:SGTC_2951|Compound:9072950|FD-Score:-4.99|P-value:6.19E-8 ID:SGTC_2953|Compound:9074162|FD-Score:6.06|P-value:6.91E-11 ID:SGTC_2971|Compound:9092186|FD-Score:4.21|P-value:4.06E-6 ID:SGTC_2979|Compound:9012552|FD-Score:-3.54|P-value:8.66E-5 ID:SGTC_2982|Compound:9019404|FD-Score:-5.04|P-value:4.65E-8 ID:SGTC_2984|Compound:9022109|FD-Score:-4.54|P-value:7.27E-7 ID:SGTC_2989|Compound:9073649|FD-Score:2.97|P-value:8.29E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-4.01|P-value:1.06E-5 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.38|P-value:1.74E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.57|P-value:7.88E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-3.74|P-value:3.67E-5 ID:SGTC_3132|Compound:9126706|FD-Score:-3.31|P-value:2.26E-4 ID:SGTC_3250|Compound:9135583|FD-Score:2.99|P-value:7.81E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.49|P-value:1.10E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.39|P-value:1.64E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.08|P-value:5.37E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:3.18|P-value:3.83E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.07|P-value:5.82E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.06|P-value:8.39E-6 ID:SGTC_323|Compound:4013-0906|FD-Score:-3.08|P-value:5.44E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.33|P-value:2.14E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:-3.20|P-value:3.39E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:5.24|P-value:1.43E-8 ID:SGTC_924|Compound:2046-0044|FD-Score:3.51|P-value:1.00E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.28|P-value:2.50E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-3.76|P-value:3.33E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:-3.02|P-value:6.73E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:4.20|P-value:4.28E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.02|P-value:6.91E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.94|P-value:9.18E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.38|P-value:1.68E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:-3.10|P-value:5.12E-4 ID:SGTC_1756|Compound:st041558|FD-Score:5.94|P-value:1.58E-10 ID:SGTC_1758|Compound:st042942|FD-Score:4.04|P-value:9.31E-6 ID:SGTC_1975|Compound:st070967|FD-Score:3.04|P-value:6.44E-4 ID:SGTC_2098|Compound:5376439|FD-Score:2.99|P-value:7.82E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.65|P-value:5.48E-5 ID:SGTC_2257|Compound:7960413|FD-Score:-3.89|P-value:1.82E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.29|P-value:2.49E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.53|P-value:8.91E-5 ID:SGTC_2432|Compound:5630864|FD-Score:3.25|P-value:2.90E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.47|P-value:1.21E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.47|P-value:1.16E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.38|P-value:1.67E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.19|P-value:3.59E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.44|P-value:4.16E-9 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.16|P-value:4.12E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.00|P-value:7.33E-4 ID:SGTC_2874|Compound:9043904|FD-Score:5.14|P-value:2.64E-8 ID:SGTC_2878|Compound:9043973|FD-Score:5.71|P-value:7.46E-10 ID:SGTC_2917|Compound:7979103|FD-Score:5.07|P-value:3.95E-8 ID:SGTC_2919|Compound:7978188|FD-Score:3.73|P-value:3.89E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-3.64|P-value:5.58E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-5.74|P-value:5.97E-10 ID:SGTC_2951|Compound:9072950|FD-Score:-4.99|P-value:6.19E-8 ID:SGTC_2953|Compound:9074162|FD-Score:6.06|P-value:6.91E-11 ID:SGTC_2971|Compound:9092186|FD-Score:4.21|P-value:4.06E-6 ID:SGTC_2979|Compound:9012552|FD-Score:-3.54|P-value:8.66E-5 ID:SGTC_2982|Compound:9019404|FD-Score:-5.04|P-value:4.65E-8 ID:SGTC_2984|Compound:9022109|FD-Score:-4.54|P-value:7.27E-7 ID:SGTC_2989|Compound:9073649|FD-Score:2.97|P-value:8.29E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-4.01|P-value:1.06E-5 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.38|P-value:1.74E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.57|P-value:7.88E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-3.74|P-value:3.67E-5 ID:SGTC_3132|Compound:9126706|FD-Score:-3.31|P-value:2.26E-4 ID:SGTC_3250|Compound:9135583|FD-Score:2.99|P-value:7.81E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.49|P-value:1.10E-4

Top fitness defect scores for YBR272C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2953 9074162 6.06 66.5 µM 6.91E-11 4 6.85E-10
2 SGTC_1756 st041558 5.94 35.5 µM 1.58E-10 1 1.44E-9
3 SGTC_2878 9043973 5.71 26.0 µM 7.46E-10 1 5.75E-9
4 SGTC_2666 tannic acid 5.44 100.0 µM 4.16E-9 iron homeostasis 13 2.67E-8
5 SGTC_921 1561-0023 5.24 372.0 µM 1.43E-8 4 8.05E-8
6 SGTC_2874 9043904 5.14 71.4 µM 2.64E-8 1 1.39E-7
7 SGTC_2917 7979103 5.07 53.8 µM 3.95E-8 9 1.99E-7
8 SGTC_2971 9092186 4.21 9.9 µM 4.06E-6 ergosterol biosynthesis 23 1.26E-5
9 SGTC_1107 amlodipine 4.20 47.0 µM 4.28E-6 25 1.32E-5
10 SGTC_310 1273-0058 4.06 1.1 µM 8.39E-6 mitochondrial stress 238 2.41E-5
11 SGTC_1758 st042942 4.04 75.2 µM 9.31E-6 18 2.65E-5
12 SGTC_2919 7978188 3.73 46.4 µM 3.89E-5 28 9.54E-5
13 SGTC_2247 cerulenin 3.65 830.0 nM 5.48E-5 25 1.30E-4
14 SGTC_3066 9117245 3.57 49.5 µM 7.88E-5 19 1.80E-4
15 SGTC_924 2046-0044 3.51 21.3 µM 1.00E-4 22 2.23E-4
16 SGTC_3254 9136651 3.49 49.5 µM 1.10E-4 DNA damage response 38 2.43E-4
17 SGTC_2516 gossypol 3.47 71.5 µM 1.21E-4 27 2.64E-4
18 SGTC_3060 1327-0027 3.38 12.5 µM 1.74E-4 50 3.67E-4
19 SGTC_762 1165-0429 3.33 115.0 µM 2.14E-4 TSC3-RPN4 41 4.41E-4
20 SGTC_2344 7990960 3.29 77.0 µM 2.49E-4 47 5.05E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.70E-20 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.134 6.10E-15 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.106 8.55E-10 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.100 6.22E-9 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.097 2.21E-8 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.094 5.81E-8 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.093 6.76E-8 YOR384W FRE5 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.088 3.20E-7 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.086 6.55E-7 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
0.083 1.51E-6 YDR193W_d YDR193W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 1.84E-6 YNR037C RSM19 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
0.082 2.07E-6 YBL018C POP8 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.082 2.23E-6 YDR034C LYS14 hom Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
0.080 3.85E-6 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.078 6.48E-6 YPL177C CUP9 hom Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress