YBR277C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR277C / YBR277C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:6.23|P-value:2.10E-10 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.81|P-value:5.67E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.14|P-value:7.24E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.19|P-value:7.24E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.42|P-value:3.11E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.51|P-value:2.22E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.50|P-value:2.33E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.41|P-value:2.72E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.23|P-value:6.38E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.17|P-value:6.56E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.61|P-value:1.56E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:5.20|P-value:9.23E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.94|P-value:2.90E-7 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.84|P-value:6.20E-7 ID:SGTC_456|Compound:gingerol|FD-Score:3.85|P-value:5.95E-5 ID:SGTC_458|Compound:nppb|FD-Score:3.20|P-value:6.96E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.83|P-value:6.53E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:-3.38|P-value:3.03E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.31|P-value:3.99E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.26|P-value:5.64E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.66|P-value:1.29E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:6.73|P-value:7.30E-12 ID:SGTC_937|Compound:3122-0005|FD-Score:3.75|P-value:8.81E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:3.24|P-value:6.16E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.12|P-value:9.27E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.22|P-value:6.57E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.88|P-value:5.21E-7 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.39|P-value:2.90E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.35|P-value:4.14E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.65|P-value:1.34E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.14|P-value:7.26E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.38|P-value:3.64E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.45|P-value:2.85E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.26|P-value:5.66E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:-3.52|P-value:1.79E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.27|P-value:5.43E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.63|P-value:1.79E-6 ID:SGTC_1387|Compound:3342-1166|FD-Score:4.92|P-value:4.10E-7 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.52|P-value:2.14E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.49|P-value:2.42E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.14|P-value:8.49E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.45|P-value:4.24E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.47|P-value:2.64E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.25|P-value:5.86E-4 ID:SGTC_1721|Compound:st082152|FD-Score:4.37|P-value:6.20E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.69|P-value:1.12E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.75|P-value:9.97E-7 ID:SGTC_2005|Compound:4024620|FD-Score:5.01|P-value:2.64E-7 ID:SGTC_2009|Compound:4012297|FD-Score:8.41|P-value:1.61E-17 ID:SGTC_2011|Compound:4012611|FD-Score:4.74|P-value:1.01E-6 ID:SGTC_2026|Compound:5148700|FD-Score:6.20|P-value:2.55E-10 ID:SGTC_2034|Compound:5197015|FD-Score:3.43|P-value:3.02E-4 ID:SGTC_2165|Compound:5727197|FD-Score:4.82|P-value:7.11E-7 ID:SGTC_2166|Compound:5933061|FD-Score:-3.42|P-value:2.64E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.23|P-value:6.37E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.52|P-value:2.16E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.17|P-value:7.67E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.32|P-value:7.75E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.26|P-value:4.73E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.24|P-value:1.11E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-3.64|P-value:1.11E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.34|P-value:5.61E-6 ID:SGTC_2938|Compound:9059746|FD-Score:-3.16|P-value:6.79E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.24|P-value:6.00E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.84|P-value:4.92E-5 ID:SGTC_3030|Compound:9087619|FD-Score:3.34|P-value:4.30E-4 ID:SGTC_3038|Compound:9091290|FD-Score:4.33|P-value:7.38E-6 ID:SGTC_3194|Compound:9111903|FD-Score:-3.08|P-value:8.94E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-4.12|P-value:1.53E-5 ID:SGTC_3232|Compound:9132874|FD-Score:5.21|P-value:9.06E-8 ID:SGTC_3244|Compound:9134489|FD-Score:4.46|P-value:4.10E-6 ID:SGTC_3245|Compound:9134821|FD-Score:3.79|P-value:7.51E-5 ID:SGTC_3246|Compound:9135460|FD-Score:4.01|P-value:3.00E-5 ID:SGTC_3248|Compound:9135562|FD-Score:4.77|P-value:8.91E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:6.23|P-value:2.10E-10 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.81|P-value:5.67E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.14|P-value:7.24E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:3.19|P-value:7.24E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.42|P-value:3.11E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.51|P-value:2.22E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.50|P-value:2.33E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.41|P-value:2.72E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.23|P-value:6.38E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.17|P-value:6.56E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.61|P-value:1.56E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:5.20|P-value:9.23E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.94|P-value:2.90E-7 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.84|P-value:6.20E-7 ID:SGTC_456|Compound:gingerol|FD-Score:3.85|P-value:5.95E-5 ID:SGTC_458|Compound:nppb|FD-Score:3.20|P-value:6.96E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.83|P-value:6.53E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:-3.38|P-value:3.03E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.31|P-value:3.99E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.26|P-value:5.64E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.66|P-value:1.29E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:6.73|P-value:7.30E-12 ID:SGTC_937|Compound:3122-0005|FD-Score:3.75|P-value:8.81E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:3.24|P-value:6.16E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:3.12|P-value:9.27E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.22|P-value:6.57E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:4.88|P-value:5.21E-7 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.39|P-value:2.90E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.35|P-value:4.14E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.65|P-value:1.34E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.14|P-value:7.26E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.38|P-value:3.64E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.45|P-value:2.85E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.26|P-value:5.66E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:-3.52|P-value:1.79E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.27|P-value:5.43E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.63|P-value:1.79E-6 ID:SGTC_1387|Compound:3342-1166|FD-Score:4.92|P-value:4.10E-7 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.52|P-value:2.14E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.49|P-value:2.42E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.14|P-value:8.49E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.45|P-value:4.24E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.47|P-value:2.64E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.25|P-value:5.86E-4 ID:SGTC_1721|Compound:st082152|FD-Score:4.37|P-value:6.20E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.69|P-value:1.12E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.75|P-value:9.97E-7 ID:SGTC_2005|Compound:4024620|FD-Score:5.01|P-value:2.64E-7 ID:SGTC_2009|Compound:4012297|FD-Score:8.41|P-value:1.61E-17 ID:SGTC_2011|Compound:4012611|FD-Score:4.74|P-value:1.01E-6 ID:SGTC_2026|Compound:5148700|FD-Score:6.20|P-value:2.55E-10 ID:SGTC_2034|Compound:5197015|FD-Score:3.43|P-value:3.02E-4 ID:SGTC_2165|Compound:5727197|FD-Score:4.82|P-value:7.11E-7 ID:SGTC_2166|Compound:5933061|FD-Score:-3.42|P-value:2.64E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.23|P-value:6.37E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.52|P-value:2.16E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.17|P-value:7.67E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.32|P-value:7.75E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.26|P-value:4.73E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.24|P-value:1.11E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-3.64|P-value:1.11E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.34|P-value:5.61E-6 ID:SGTC_2938|Compound:9059746|FD-Score:-3.16|P-value:6.79E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.24|P-value:6.00E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-3.84|P-value:4.92E-5 ID:SGTC_3030|Compound:9087619|FD-Score:3.34|P-value:4.30E-4 ID:SGTC_3038|Compound:9091290|FD-Score:4.33|P-value:7.38E-6 ID:SGTC_3194|Compound:9111903|FD-Score:-3.08|P-value:8.94E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-4.12|P-value:1.53E-5 ID:SGTC_3232|Compound:9132874|FD-Score:5.21|P-value:9.06E-8 ID:SGTC_3244|Compound:9134489|FD-Score:4.46|P-value:4.10E-6 ID:SGTC_3245|Compound:9134821|FD-Score:3.79|P-value:7.51E-5 ID:SGTC_3246|Compound:9135460|FD-Score:4.01|P-value:3.00E-5 ID:SGTC_3248|Compound:9135562|FD-Score:4.77|P-value:8.91E-7

Top fitness defect scores for YBR277C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2009 4012297 8.41 12.1 µM 1.61E-17 cell wall signaling 12 2.08E-17
2 SGTC_921 1561-0023 6.73 372.0 µM 7.30E-12 1 8.33E-12
3 SGTC_58 0957-0393 6.23 9.0 µM 2.10E-10 cell wall 203 2.32E-10
4 SGTC_2026 5148700 6.20 152.0 µM 2.55E-10 5 2.81E-10
5 SGTC_3232 9132874 5.21 49.5 µM 9.06E-8 RPP1 & pyrimidine depletion 4 9.52E-8
6 SGTC_450 aminopyrene 5.20 156.0 nM 9.23E-8 12 9.70E-8
7 SGTC_2005 4024620 5.01 188.0 µM 2.64E-7 6 2.76E-7
8 SGTC_1387 3342-1166 4.92 1.8 µM 4.10E-7 mitochondrial processes 5 4.25E-7
9 SGTC_1031 k035-0009 4.88 16.0 µM 5.21E-7 11 5.40E-7
10 SGTC_454 lyso-paf C-16 4.84 6.7 µM 6.20E-7 5 6.41E-7
11 SGTC_2165 5727197 4.82 32.1 µM 7.11E-7 21 7.35E-7
12 SGTC_3248 9135562 4.77 49.5 µM 8.91E-7 2 9.20E-7
13 SGTC_2002 4023503 4.75 131.0 µM 9.97E-7 mitochondrial processes 15 1.03E-6
14 SGTC_2011 4012611 4.74 177.0 µM 1.01E-6 mitochondrial processes 15 1.05E-6
15 SGTC_1377 2944-0135 4.63 198.0 µM 1.79E-6 calcium & mitochondrial duress 20 1.84E-6
16 SGTC_3244 9134489 4.46 49.5 µM 4.10E-6 10 4.18E-6
17 SGTC_1537 2',6'-dihydroxyflavanone 4.45 78.0 µM 4.24E-6 10 4.32E-6
18 SGTC_1721 st082152 4.37 9.3 µM 6.20E-6 60S ribosome export 13 6.30E-6
19 SGTC_3038 9091290 4.33 49.5 µM 7.38E-6 10 7.49E-6
20 SGTC_2584 androsterone 4.32 48.7 µM 7.75E-6 cell wall 105 7.87E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 7.25E-17 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.143 9.29E-17 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.141 1.82E-16 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.136 2.86E-15 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.136 2.91E-15 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.126 2.38E-13 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.125 3.33E-13 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.122 1.21E-12 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.119 4.19E-12 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.115 2.33E-11 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.113 4.84E-11 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.112 7.20E-11 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.112 8.61E-11 YJL125C GCD14 het Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.107 4.76E-10 YJL020C BBC1 hom Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
0.107 4.80E-10 YCR079W PTC6 hom Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase