| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|
| 0.103 |
2.31E-9 |
YKL153W_d |
YKL153W_d |
het |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant |
| 0.100 |
7.16E-9 |
YLR142W |
PUT1 |
hom |
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source |
| 0.097 |
1.80E-8 |
YHR110W |
ERP5 |
hom |
Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport |
| 0.091 |
1.27E-7 |
YLR357W |
RSC2 |
hom |
Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance |
| 0.087 |
4.04E-7 |
YNL321W |
VNX1 |
hom |
Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate |
| 0.085 |
7.68E-7 |
YIL118W |
RHO3 |
het |
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p |
| 0.084 |
1.10E-6 |
YPL160W |
CDC60 |
het |
Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA |
| 0.082 |
2.01E-6 |
YMR147W_p |
YMR147W_p |
hom |
Putative protein of unknown function |
| 0.077 |
8.55E-6 |
YPL090C |
RPS6A |
hom |
Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication |
| 0.077 |
9.30E-6 |
YLR131C |
ACE2 |
hom |
Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication |
| 0.076 |
1.18E-5 |
YLR216C |
CPR6 |
hom |
Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress |
| 0.074 |
1.61E-5 |
YDR152W |
GIR2 |
hom |
Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein |
| 0.074 |
1.72E-5 |
YLR276C |
DBP9 |
het |
DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain |
| 0.074 |
1.88E-5 |
YDR083W |
RRP8 |
hom |
Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1 |
| 0.072 |
3.03E-5 |
YPR032W |
SRO7 |
hom |
Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication |
