YBR299W / MAL32

Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR299W / MAL32

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:5.88|P-value:5.26E-9 ID:SGTC_71|Compound:0417-1750|FD-Score:5.03|P-value:4.79E-7 ID:SGTC_139|Compound:0099-0334|FD-Score:3.22|P-value:8.54E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.32|P-value:6.14E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.49|P-value:3.38E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.92|P-value:6.85E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-5.07|P-value:4.43E-7 ID:SGTC_369|Compound:0957-0393|FD-Score:3.54|P-value:2.86E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.76|P-value:1.34E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.51|P-value:3.29E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.27|P-value:7.15E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.82|P-value:1.06E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.20|P-value:9.12E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:8.36|P-value:2.14E-16 ID:SGTC_762|Compound:1165-0429|FD-Score:3.87|P-value:8.25E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:6.02|P-value:2.27E-9 ID:SGTC_786|Compound:4544-0069|FD-Score:3.63|P-value:1.99E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.58|P-value:2.43E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.23|P-value:8.25E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.20|P-value:9.11E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.67|P-value:1.75E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.45|P-value:3.82E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.29|P-value:6.68E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.25|P-value:7.81E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:8.96|P-value:1.41E-18 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.31|P-value:6.22E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-4.42|P-value:8.96E-6 ID:SGTC_1336|Compound:1486-0901|FD-Score:-6.35|P-value:3.59E-10 ID:SGTC_1341|Compound:1486-1360|FD-Score:-4.06|P-value:4.18E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:5.15|P-value:2.72E-7 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.21|P-value:8.77E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.85|P-value:8.83E-5 ID:SGTC_1610|Compound:st001799|FD-Score:-3.79|P-value:1.18E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.56|P-value:2.64E-4 ID:SGTC_1720|Compound:st037298|FD-Score:5.32|P-value:1.09E-7 ID:SGTC_1743|Compound:st037606|FD-Score:3.36|P-value:5.32E-4 ID:SGTC_1772|Compound:st048439|FD-Score:3.68|P-value:1.69E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-4.17|P-value:2.58E-5 ID:SGTC_1799|Compound:st045822|FD-Score:3.19|P-value:9.39E-4 ID:SGTC_1925|Compound:st057770|FD-Score:4.56|P-value:4.47E-6 ID:SGTC_2045|Compound:5106652|FD-Score:3.73|P-value:1.40E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.23|P-value:8.20E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.58|P-value:2.46E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-5.69|P-value:1.70E-8 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.99|P-value:5.39E-5 ID:SGTC_2473|Compound:5854593|FD-Score:-3.21|P-value:9.31E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.25|P-value:8.20E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.31|P-value:1.37E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.44|P-value:4.03E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.94|P-value:6.27E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.47|P-value:3.59E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.36|P-value:5.27E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-3.25|P-value:8.16E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:5.88|P-value:5.26E-9 ID:SGTC_71|Compound:0417-1750|FD-Score:5.03|P-value:4.79E-7 ID:SGTC_139|Compound:0099-0334|FD-Score:3.22|P-value:8.54E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.32|P-value:6.14E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.49|P-value:3.38E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.92|P-value:6.85E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-5.07|P-value:4.43E-7 ID:SGTC_369|Compound:0957-0393|FD-Score:3.54|P-value:2.86E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.76|P-value:1.34E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.51|P-value:3.29E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.27|P-value:7.15E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.82|P-value:1.06E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.20|P-value:9.12E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:8.36|P-value:2.14E-16 ID:SGTC_762|Compound:1165-0429|FD-Score:3.87|P-value:8.25E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:6.02|P-value:2.27E-9 ID:SGTC_786|Compound:4544-0069|FD-Score:3.63|P-value:1.99E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.58|P-value:2.43E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:3.23|P-value:8.25E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:3.20|P-value:9.11E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.67|P-value:1.75E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.45|P-value:3.82E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.29|P-value:6.68E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.25|P-value:7.81E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:8.96|P-value:1.41E-18 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.31|P-value:6.22E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-4.42|P-value:8.96E-6 ID:SGTC_1336|Compound:1486-0901|FD-Score:-6.35|P-value:3.59E-10 ID:SGTC_1341|Compound:1486-1360|FD-Score:-4.06|P-value:4.18E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:5.15|P-value:2.72E-7 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.21|P-value:8.77E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.85|P-value:8.83E-5 ID:SGTC_1610|Compound:st001799|FD-Score:-3.79|P-value:1.18E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.56|P-value:2.64E-4 ID:SGTC_1720|Compound:st037298|FD-Score:5.32|P-value:1.09E-7 ID:SGTC_1743|Compound:st037606|FD-Score:3.36|P-value:5.32E-4 ID:SGTC_1772|Compound:st048439|FD-Score:3.68|P-value:1.69E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-4.17|P-value:2.58E-5 ID:SGTC_1799|Compound:st045822|FD-Score:3.19|P-value:9.39E-4 ID:SGTC_1925|Compound:st057770|FD-Score:4.56|P-value:4.47E-6 ID:SGTC_2045|Compound:5106652|FD-Score:3.73|P-value:1.40E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.23|P-value:8.20E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.58|P-value:2.46E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-5.69|P-value:1.70E-8 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.99|P-value:5.39E-5 ID:SGTC_2473|Compound:5854593|FD-Score:-3.21|P-value:9.31E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.25|P-value:8.20E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.31|P-value:1.37E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.44|P-value:4.03E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.94|P-value:6.27E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.47|P-value:3.59E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.36|P-value:5.27E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-3.25|P-value:8.16E-4

Top fitness defect scores for YBR299W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1251 0490-5699 8.96 265.0 µM 1.41E-18 1 1.60E-19
2 SGTC_669 0108-0021 8.36 26.2 µM 2.14E-16 fatty acid desaturase (OLE1) 9 3.22E-17
3 SGTC_769 0302-0231 6.02 76.0 µM 2.27E-9 8 8.50E-10
4 SGTC_68 0986-0284 5.88 82.8 µM 5.26E-9 21 2.06E-9
5 SGTC_1720 st037298 5.32 9.5 µM 1.09E-7 16 5.06E-8
6 SGTC_1359 1582-0056 5.15 520.0 nM 2.72E-7 5 1.33E-7
7 SGTC_71 0417-1750 5.03 47.8 µM 4.79E-7 Golgi 25 2.41E-7
8 SGTC_1925 st057770 4.56 10.1 µM 4.47E-6 TSC3-RPN4 13 2.54E-6
9 SGTC_2605 digitonin 4.31 300.0 nM 1.37E-5 19 8.28E-6
10 SGTC_2616 abietic acid 3.94 100.0 µM 6.27E-5 30 4.11E-5
11 SGTC_356 1634-0012 3.92 32.5 µM 6.85E-5 26 4.52E-5
12 SGTC_762 1165-0429 3.87 115.0 µM 8.25E-5 TSC3-RPN4 21 5.49E-5
13 SGTC_1573 oleylamine 3.85 1.1 µM 8.83E-5 28 5.90E-5
14 SGTC_2045 5106652 3.73 78.0 µM 1.40E-4 18 9.61E-5
15 SGTC_1772 st048439 3.68 82.2 µM 1.69E-4 44 1.17E-4
16 SGTC_996 3970-0799 3.67 1.8 µM 1.75E-4 98 1.21E-4
17 SGTC_786 4544-0069 3.63 423.0 µM 1.99E-4 46 1.39E-4
18 SGTC_851 0394-0702 3.58 453.0 µM 2.43E-4 mitochondrial processes 21 1.71E-4
19 SGTC_2338 7999974 3.58 200.0 µM 2.46E-4 33 1.73E-4
20 SGTC_1634 st006576 3.56 41.0 µM 2.64E-4 TSC3-RPN4 29 1.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.33E-19 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.153 4.76E-19 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.150 2.38E-18 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.150 2.43E-18 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.149 3.68E-18 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.149 5.26E-18 YDR044W HEM13 het Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
0.145 2.66E-17 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.143 7.60E-17 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.140 4.57E-16 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.131 3.05E-14 YOR060C SLD7 het Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
0.127 1.90E-13 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.126 2.37E-13 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.124 7.07E-13 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.122 1.11E-12 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.121 1.69E-12 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA