YBR300C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR300C / YBR300C

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:4.19|P-value:8.75E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:3.50|P-value:8.33E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.65|P-value:7.64E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.06|P-value:3.13E-8 ID:SGTC_212|Compound:3807-4682|FD-Score:4.31|P-value:5.68E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-4.84|P-value:1.24E-5 ID:SGTC_277|Compound:nystatin|FD-Score:3.44|P-value:9.80E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.86|P-value:2.68E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.17|P-value:9.22E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.63|P-value:5.59E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.57|P-value:9.83E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.57|P-value:2.18E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:4.71|P-value:1.25E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.47|P-value:9.08E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.62|P-value:5.65E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:-4.26|P-value:1.07E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:4.23|P-value:7.46E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.17|P-value:9.38E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.58|P-value:6.46E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.57|P-value:9.79E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.78|P-value:3.42E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.38|P-value:4.39E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:5.67|P-value:2.03E-7 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.64|P-value:5.45E-4 ID:SGTC_1620|Compound:st003704|FD-Score:-4.06|P-value:2.07E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.26|P-value:6.76E-5 ID:SGTC_1907|Compound:st060210|FD-Score:3.76|P-value:3.62E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.36|P-value:4.67E-5 ID:SGTC_1923|Compound:st058458|FD-Score:-5.83|P-value:1.78E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.12|P-value:1.10E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.57|P-value:6.59E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.81|P-value:3.14E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.83|P-value:2.94E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.56|P-value:6.87E-4 ID:SGTC_2466|Compound:5983409|FD-Score:5.05|P-value:3.10E-6 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.71|P-value:1.24E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.42|P-value:3.75E-5 ID:SGTC_2783|Compound:7738165|FD-Score:4.36|P-value:4.68E-5 ID:SGTC_2809|Compound:7964133|FD-Score:4.61|P-value:1.85E-5 ID:SGTC_2817|Compound:7995342|FD-Score:4.13|P-value:1.07E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.07|P-value:1.30E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.72|P-value:4.14E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.57|P-value:6.75E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-3.87|P-value:3.87E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.63|P-value:8.18E-4 ID:SGTC_3216|Compound:9129716|FD-Score:4.71|P-value:1.24E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:4.19|P-value:8.75E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:3.50|P-value:8.33E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-3.65|P-value:7.64E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.06|P-value:3.13E-8 ID:SGTC_212|Compound:3807-4682|FD-Score:4.31|P-value:5.68E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-4.84|P-value:1.24E-5 ID:SGTC_277|Compound:nystatin|FD-Score:3.44|P-value:9.80E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.86|P-value:2.68E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.17|P-value:9.22E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.63|P-value:5.59E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.57|P-value:9.83E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.57|P-value:2.18E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:4.71|P-value:1.25E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.47|P-value:9.08E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.62|P-value:5.65E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:-4.26|P-value:1.07E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:4.23|P-value:7.46E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:4.17|P-value:9.38E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.58|P-value:6.46E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:-3.57|P-value:9.79E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.78|P-value:3.42E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.38|P-value:4.39E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:5.67|P-value:2.03E-7 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.64|P-value:5.45E-4 ID:SGTC_1620|Compound:st003704|FD-Score:-4.06|P-value:2.07E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.26|P-value:6.76E-5 ID:SGTC_1907|Compound:st060210|FD-Score:3.76|P-value:3.62E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.36|P-value:4.67E-5 ID:SGTC_1923|Compound:st058458|FD-Score:-5.83|P-value:1.78E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.12|P-value:1.10E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.57|P-value:6.59E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.81|P-value:3.14E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.83|P-value:2.94E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.56|P-value:6.87E-4 ID:SGTC_2466|Compound:5983409|FD-Score:5.05|P-value:3.10E-6 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.71|P-value:1.24E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.42|P-value:3.75E-5 ID:SGTC_2783|Compound:7738165|FD-Score:4.36|P-value:4.68E-5 ID:SGTC_2809|Compound:7964133|FD-Score:4.61|P-value:1.85E-5 ID:SGTC_2817|Compound:7995342|FD-Score:4.13|P-value:1.07E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.07|P-value:1.30E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.72|P-value:4.14E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.57|P-value:6.75E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-3.87|P-value:3.87E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-3.63|P-value:8.18E-4 ID:SGTC_3216|Compound:9129716|FD-Score:4.71|P-value:1.24E-5

Top fitness defect scores for YBR300C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 6.06 9.0 µM 3.13E-8 cell wall 212 6.64E-10
2 SGTC_1378 2093-0007 5.67 380.0 nM 2.03E-7 2 6.99E-9
3 SGTC_2466 5983409 5.05 37.1 µM 3.10E-6 8 2.16E-7
4 SGTC_3216 9129716 4.71 49.5 µM 1.24E-5 RPP1 & pyrimidine depletion 14 1.23E-6
5 SGTC_2634 4'-methoxyflavone 4.71 100.0 µM 1.24E-5 16 1.24E-6
6 SGTC_738 1315-0003 4.71 72.4 µM 1.25E-5 12 1.24E-6
7 SGTC_2809 7964133 4.61 13.0 µM 1.85E-5 60S ribosome export 20 2.03E-6
8 SGTC_706 4262-0057 4.57 46.9 µM 2.18E-5 fatty acid desaturase (OLE1) 17 2.49E-6
9 SGTC_2663 amphotericin b 4.42 100.0 µM 3.75E-5 8 4.92E-6
10 SGTC_1340 1486-1359 4.38 257.0 µM 4.39E-5 9 6.00E-6
11 SGTC_1911 st060208 4.36 74.3 µM 4.67E-5 25 6.48E-6
12 SGTC_2783 7738165 4.36 71.4 µM 4.68E-5 23 6.50E-6
13 SGTC_212 3807-4682 4.31 38.8 µM 5.68E-5 tubulin folding & SWR complex 51 8.29E-6
14 SGTC_1891 st059073 4.26 26.2 µM 6.76E-5 TSC3-RPN4 17 1.03E-5
15 SGTC_1109 tnp00067 4.23 928.3 nM 7.46E-5 9 1.16E-5
16 SGTC_16 erodoxin 4.19 22.8 µM 8.75E-5 unfolded protein response 59 1.42E-5
17 SGTC_304 1310-0298 4.17 97.0 µM 9.22E-5 cell wall 55 1.52E-5
18 SGTC_1178 0988-0033 4.17 191.0 µM 9.38E-5 23 1.55E-5
19 SGTC_2817 7995342 4.13 71.4 µM 1.07E-4 19 1.83E-5
20 SGTC_1926 methyl fluorone black 4.12 53.6 µM 1.10E-4 DNA intercalators 54 1.90E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 3.92E-19 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.153 6.04E-19 YNL205C_d YNL205C_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.142 1.26E-16 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.127 1.60E-13 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.122 1.41E-12 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.120 2.75E-12 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.119 5.03E-12 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.117 1.16E-11 YBR297W MAL33 hom MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
0.109 2.08E-10 YCR026C NPP1 hom Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication
0.109 2.31E-10 YCR024C-A PMP1 hom Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication
0.107 5.42E-10 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.106 7.52E-10 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.103 2.23E-9 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.103 2.65E-9 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102 3.44E-9 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane