YCL010C / SGF29

Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL010C / SGF29

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-4.38|P-value:2.42E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:6.50|P-value:4.15E-12 ID:SGTC_147|Compound:4466-0538|FD-Score:4.76|P-value:2.72E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:3.26|P-value:3.03E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.92|P-value:1.17E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:4.98|P-value:8.20E-8 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.57|P-value:9.82E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.23|P-value:3.37E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.32|P-value:2.34E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-3.86|P-value:2.74E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:7.03|P-value:7.91E-14 ID:SGTC_297|Compound:0986-0032|FD-Score:-3.53|P-value:1.13E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.25|P-value:3.10E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:9.29|P-value:8.45E-23 ID:SGTC_305|Compound:1682-2595|FD-Score:9.58|P-value:4.10E-24 ID:SGTC_312|Compound:4092-0653|FD-Score:6.67|P-value:1.20E-12 ID:SGTC_317|Compound:4495-0002|FD-Score:-3.41|P-value:1.89E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.81|P-value:3.06E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:6.47|P-value:5.33E-12 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.05|P-value:7.22E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.15|P-value:4.99E-4 ID:SGTC_397|Compound:arbidol|FD-Score:4.22|P-value:4.56E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:2.93|P-value:9.98E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.07|P-value:6.04E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.52|P-value:1.21E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.09|P-value:5.71E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.14|P-value:4.72E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.00|P-value:1.31E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:4.20|P-value:4.89E-6 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.03|P-value:1.30E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:3.02|P-value:7.29E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.01|P-value:8.54E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.97|P-value:1.44E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.30|P-value:2.52E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.32|P-value:2.34E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.24|P-value:3.27E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.88|P-value:2.21E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.88|P-value:2.23E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.45|P-value:1.63E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.69|P-value:5.86E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.49|P-value:1.36E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.27|P-value:2.89E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.33|P-value:2.30E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.86|P-value:2.39E-5 ID:SGTC_1547|Compound:harmine|FD-Score:4.77|P-value:2.61E-7 ID:SGTC_1627|Compound:st003713|FD-Score:5.76|P-value:6.86E-10 ID:SGTC_1633|Compound:st005664|FD-Score:3.22|P-value:3.44E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.04|P-value:6.92E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.07|P-value:6.19E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.52|P-value:1.20E-4 ID:SGTC_1701|Compound:st028638|FD-Score:-3.00|P-value:8.74E-4 ID:SGTC_1709|Compound:st033179|FD-Score:4.58|P-value:7.40E-7 ID:SGTC_1750|Compound:st081859|FD-Score:3.63|P-value:6.68E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.68|P-value:4.35E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.49|P-value:1.19E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.34|P-value:2.17E-4 ID:SGTC_1801|Compound:st050089|FD-Score:2.98|P-value:8.31E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.23|P-value:3.39E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.20|P-value:4.15E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.28|P-value:2.71E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.19|P-value:4.36E-4 ID:SGTC_2425|Compound:5628681|FD-Score:-3.23|P-value:3.81E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.15|P-value:6.21E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.13|P-value:4.97E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.01|P-value:7.49E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.13|P-value:5.43E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.69|P-value:5.10E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.66|P-value:5.77E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.00|P-value:8.87E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.24|P-value:4.09E-6 ID:SGTC_3007|Compound:9078383|FD-Score:4.15|P-value:6.38E-6 ID:SGTC_3009|Compound:9080819|FD-Score:3.01|P-value:7.48E-4 ID:SGTC_3102|Compound:9121669|FD-Score:-3.40|P-value:1.97E-4 ID:SGTC_3118|Compound:9124250|FD-Score:2.94|P-value:9.74E-4 ID:SGTC_3152|Compound:9099253|FD-Score:7.09|P-value:4.72E-14 ID:SGTC_3170|Compound:9103054|FD-Score:-3.34|P-value:2.43E-4 ID:SGTC_3202|Compound:9113761|FD-Score:2.95|P-value:9.47E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.71|P-value:4.62E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.38|P-value:2.42E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:6.50|P-value:4.15E-12 ID:SGTC_147|Compound:4466-0538|FD-Score:4.76|P-value:2.72E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:3.26|P-value:3.03E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.92|P-value:1.17E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:4.98|P-value:8.20E-8 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.57|P-value:9.82E-5 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.23|P-value:3.37E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.32|P-value:2.34E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-3.86|P-value:2.74E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:7.03|P-value:7.91E-14 ID:SGTC_297|Compound:0986-0032|FD-Score:-3.53|P-value:1.13E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.25|P-value:3.10E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:9.29|P-value:8.45E-23 ID:SGTC_305|Compound:1682-2595|FD-Score:9.58|P-value:4.10E-24 ID:SGTC_312|Compound:4092-0653|FD-Score:6.67|P-value:1.20E-12 ID:SGTC_317|Compound:4495-0002|FD-Score:-3.41|P-value:1.89E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.81|P-value:3.06E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:6.47|P-value:5.33E-12 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.05|P-value:7.22E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.15|P-value:4.99E-4 ID:SGTC_397|Compound:arbidol|FD-Score:4.22|P-value:4.56E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:2.93|P-value:9.98E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.07|P-value:6.04E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.52|P-value:1.21E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.09|P-value:5.71E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.14|P-value:4.72E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.00|P-value:1.31E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:4.20|P-value:4.89E-6 ID:SGTC_893|Compound:0958-0369|FD-Score:-4.03|P-value:1.30E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:3.02|P-value:7.29E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.01|P-value:8.54E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:3.97|P-value:1.44E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.30|P-value:2.52E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.32|P-value:2.34E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.24|P-value:3.27E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.88|P-value:2.21E-5 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.88|P-value:2.23E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.45|P-value:1.63E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.69|P-value:5.86E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.49|P-value:1.36E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.27|P-value:2.89E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.33|P-value:2.30E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.86|P-value:2.39E-5 ID:SGTC_1547|Compound:harmine|FD-Score:4.77|P-value:2.61E-7 ID:SGTC_1627|Compound:st003713|FD-Score:5.76|P-value:6.86E-10 ID:SGTC_1633|Compound:st005664|FD-Score:3.22|P-value:3.44E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.04|P-value:6.92E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.07|P-value:6.19E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.52|P-value:1.20E-4 ID:SGTC_1701|Compound:st028638|FD-Score:-3.00|P-value:8.74E-4 ID:SGTC_1709|Compound:st033179|FD-Score:4.58|P-value:7.40E-7 ID:SGTC_1750|Compound:st081859|FD-Score:3.63|P-value:6.68E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.68|P-value:4.35E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.49|P-value:1.19E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.34|P-value:2.17E-4 ID:SGTC_1801|Compound:st050089|FD-Score:2.98|P-value:8.31E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.23|P-value:3.39E-4 ID:SGTC_1870|Compound:st057514|FD-Score:-3.20|P-value:4.15E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.28|P-value:2.71E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.19|P-value:4.36E-4 ID:SGTC_2425|Compound:5628681|FD-Score:-3.23|P-value:3.81E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.15|P-value:6.21E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.13|P-value:4.97E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.01|P-value:7.49E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.13|P-value:5.43E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.69|P-value:5.10E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.66|P-value:5.77E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.00|P-value:8.87E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.24|P-value:4.09E-6 ID:SGTC_3007|Compound:9078383|FD-Score:4.15|P-value:6.38E-6 ID:SGTC_3009|Compound:9080819|FD-Score:3.01|P-value:7.48E-4 ID:SGTC_3102|Compound:9121669|FD-Score:-3.40|P-value:1.97E-4 ID:SGTC_3118|Compound:9124250|FD-Score:2.94|P-value:9.74E-4 ID:SGTC_3152|Compound:9099253|FD-Score:7.09|P-value:4.72E-14 ID:SGTC_3170|Compound:9103054|FD-Score:-3.34|P-value:2.43E-4 ID:SGTC_3202|Compound:9113761|FD-Score:2.95|P-value:9.47E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.71|P-value:4.62E-5

Top fitness defect scores for YCL010C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_305 1682-2595 9.58 20.8 µM 4.10E-24 RNA processing & uracil transport 2 4.71E-22
2 SGTC_304 1310-0298 9.29 97.0 µM 8.45E-23 cell wall 2 7.38E-21
3 SGTC_3152 9099253 7.09 49.5 µM 4.72E-14 NEO1-PIK1 40 6.67E-13
4 SGTC_288 1315-0019 7.03 35.1 µM 7.91E-14 RSC & ERG11 2 1.07E-12
5 SGTC_312 4092-0653 6.67 6.8 µM 1.20E-12 ergosterol depletion effects on membrane 28 1.27E-11
6 SGTC_138 0850-0259 6.50 40.9 µM 4.15E-12 cell wall 89 3.92E-11
7 SGTC_388 3',4'-dichloroisocoumarin 6.47 16.7 µM 5.33E-12 2 4.92E-11
8 SGTC_1627 st003713 5.76 25.6 µM 6.86E-10 calcium & mitochondrial duress 33 4.09E-9
9 SGTC_178 4092-0806 4.98 87.5 µM 8.20E-8 ergosterol depletion effects on membrane 56 3.18E-7
10 SGTC_168 3970-0862 4.92 530.5 µM 1.17E-7 72 4.41E-7
11 SGTC_1547 harmine 4.77 94.2 µM 2.61E-7 ergosterol biosynthesis 26 9.12E-7
12 SGTC_147 4466-0538 4.76 29.2 µM 2.72E-7 ergosterol biosynthesis 8 9.46E-7
13 SGTC_1754 st042065 4.68 16.1 µM 4.35E-7 NEO1-PIK1 144 1.45E-6
14 SGTC_1709 st033179 4.58 39.1 µM 7.40E-7 4 2.35E-6
15 SGTC_2937 9044753 4.24 11.3 µM 4.09E-6 60S ribosome export 28 1.12E-5
16 SGTC_397 arbidol 4.22 50.0 µM 4.56E-6 cell wall 15 1.23E-5
17 SGTC_829 1635-0120 4.20 117.0 µM 4.89E-6 DNA damage response 35 1.31E-5
18 SGTC_2479 5617353 4.15 43.9 µM 6.21E-6 33 1.64E-5
19 SGTC_3007 9078383 4.15 71.4 µM 6.38E-6 11 1.67E-5
20 SGTC_736 0958-0254 4.00 92.6 µM 1.31E-5 Golgi 30 3.23E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.180 1.16E-25 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.171 2.32E-23 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.147 1.00E-17 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.146 1.74E-17 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.138 1.29E-15 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.136 3.13E-15 YBL046W PSY4 hom Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2
0.135 4.00E-15 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.133 9.22E-15 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.132 1.89E-14 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.130 4.63E-14 YDR016C DAD1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.128 1.01E-13 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.128 1.25E-13 YML109W ZDS2 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication
0.127 1.72E-13 YJL073W JEM1 hom DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
0.126 2.13E-13 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.124 5.27E-13 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP