YCL012C

Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL012C / YCL012C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.63|P-value:7.00E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:-2.96|P-value:9.78E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-2.99|P-value:8.85E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:3.34|P-value:2.00E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.27|P-value:2.61E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:2.99|P-value:7.48E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.59|P-value:7.00E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.00|P-value:8.55E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:2.95|P-value:8.65E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.13|P-value:4.46E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.14|P-value:4.37E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.10|P-value:5.75E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.29|P-value:2.45E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-4.29|P-value:3.39E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:-4.00|P-value:1.36E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.61|P-value:1.46E-9 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.74|P-value:2.59E-7 ID:SGTC_1336|Compound:1486-0901|FD-Score:-2.98|P-value:8.93E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.82|P-value:2.56E-5 ID:SGTC_1689|Compound:st020265|FD-Score:3.72|P-value:4.05E-5 ID:SGTC_1694|Compound:st024011|FD-Score:-3.30|P-value:2.68E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.43|P-value:1.39E-6 ID:SGTC_1731|Compound:st035964|FD-Score:2.94|P-value:8.94E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.22|P-value:3.72E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.09|P-value:6.15E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.04|P-value:7.23E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.59|P-value:6.09E-7 ID:SGTC_2011|Compound:4012611|FD-Score:-3.48|P-value:1.33E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.51|P-value:1.00E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.59|P-value:7.00E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.25|P-value:2.90E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.60|P-value:8.21E-5 ID:SGTC_2243|Compound:6634756|FD-Score:3.36|P-value:1.87E-4 ID:SGTC_2244|Compound:6635614|FD-Score:3.05|P-value:6.06E-4 ID:SGTC_2245|Compound:6637752|FD-Score:3.19|P-value:3.55E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.60|P-value:6.73E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.03|P-value:6.65E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.05|P-value:5.99E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.07|P-value:5.70E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.63|P-value:7.04E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.81|P-value:3.17E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.31|P-value:2.63E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.98|P-value:8.46E-8 ID:SGTC_2585|Compound:alliin|FD-Score:5.63|P-value:1.34E-9 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-4.88|P-value:1.50E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.41|P-value:5.34E-9 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.58|P-value:7.59E-5 ID:SGTC_2710|Compound:st078562|FD-Score:-2.99|P-value:8.79E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.93|P-value:1.60E-5 ID:SGTC_2816|Compound:7982706|FD-Score:2.95|P-value:8.69E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.75|P-value:4.16E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.34|P-value:2.31E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.17|P-value:3.90E-4 ID:SGTC_3123|Compound:9126162|FD-Score:5.30|P-value:1.03E-8 ID:SGTC_3147|Compound:9097027|FD-Score:3.89|P-value:1.87E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.65|P-value:6.49E-5 ID:SGTC_3179|Compound:9107801|FD-Score:-3.57|P-value:9.01E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.33|P-value:2.09E-4 ID:SGTC_3273|Compound:9137859|FD-Score:3.07|P-value:5.63E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.79|P-value:3.01E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.63|P-value:7.00E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:-2.96|P-value:9.78E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-2.99|P-value:8.85E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:3.34|P-value:2.00E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.27|P-value:2.61E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:2.99|P-value:7.48E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.59|P-value:7.00E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.00|P-value:8.55E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:2.95|P-value:8.65E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.13|P-value:4.46E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.14|P-value:4.37E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.10|P-value:5.75E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.29|P-value:2.45E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-4.29|P-value:3.39E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:-4.00|P-value:1.36E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.61|P-value:1.46E-9 ID:SGTC_1266|Compound:0828-0227|FD-Score:4.74|P-value:2.59E-7 ID:SGTC_1336|Compound:1486-0901|FD-Score:-2.98|P-value:8.93E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.82|P-value:2.56E-5 ID:SGTC_1689|Compound:st020265|FD-Score:3.72|P-value:4.05E-5 ID:SGTC_1694|Compound:st024011|FD-Score:-3.30|P-value:2.68E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.43|P-value:1.39E-6 ID:SGTC_1731|Compound:st035964|FD-Score:2.94|P-value:8.94E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.22|P-value:3.72E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.09|P-value:6.15E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.04|P-value:7.23E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.59|P-value:6.09E-7 ID:SGTC_2011|Compound:4012611|FD-Score:-3.48|P-value:1.33E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.51|P-value:1.00E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.59|P-value:7.00E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.25|P-value:2.90E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.60|P-value:8.21E-5 ID:SGTC_2243|Compound:6634756|FD-Score:3.36|P-value:1.87E-4 ID:SGTC_2244|Compound:6635614|FD-Score:3.05|P-value:6.06E-4 ID:SGTC_2245|Compound:6637752|FD-Score:3.19|P-value:3.55E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.60|P-value:6.73E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.03|P-value:6.65E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.05|P-value:5.99E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.07|P-value:5.70E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.63|P-value:7.04E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.81|P-value:3.17E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.31|P-value:2.63E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.98|P-value:8.46E-8 ID:SGTC_2585|Compound:alliin|FD-Score:5.63|P-value:1.34E-9 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-4.88|P-value:1.50E-7 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.41|P-value:5.34E-9 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.58|P-value:7.59E-5 ID:SGTC_2710|Compound:st078562|FD-Score:-2.99|P-value:8.79E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.93|P-value:1.60E-5 ID:SGTC_2816|Compound:7982706|FD-Score:2.95|P-value:8.69E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.75|P-value:4.16E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.34|P-value:2.31E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.17|P-value:3.90E-4 ID:SGTC_3123|Compound:9126162|FD-Score:5.30|P-value:1.03E-8 ID:SGTC_3147|Compound:9097027|FD-Score:3.89|P-value:1.87E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-3.65|P-value:6.49E-5 ID:SGTC_3179|Compound:9107801|FD-Score:-3.57|P-value:9.01E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.33|P-value:2.09E-4 ID:SGTC_3273|Compound:9137859|FD-Score:3.07|P-value:5.63E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.79|P-value:3.01E-5

Top fitness defect scores for YCL012C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2585 alliin 5.63 100.0 µM 1.34E-9 8 9.18E-9
2 SGTC_1263 0774-1208 5.61 64.8 µM 1.46E-9 11 9.89E-9
3 SGTC_2612 dictamnine 5.41 15.5 µM 5.34E-9 RNA pol III & RNase P/MRP 19 3.18E-8
4 SGTC_3123 9126162 5.30 49.5 µM 1.03E-8 6 5.72E-8
5 SGTC_1266 0828-0227 4.74 32.9 µM 2.59E-7 9 1.05E-6
6 SGTC_1912 st060209 4.59 90.8 µM 6.09E-7 23 2.26E-6
7 SGTC_1727 st034309 4.43 9.9 µM 1.39E-6 23 4.75E-6
8 SGTC_2722 naftopidil 3.93 47.2 µM 1.60E-5 8 4.30E-5
9 SGTC_3147 9097027 3.89 49.5 µM 1.87E-5 26 4.95E-5
10 SGTC_1501 4491-0275 3.82 38.4 µM 2.56E-5 12 6.56E-5
11 SGTC_3294 9122953 3.79 26.3 µM 3.01E-5 tubulin folding & SWR complex 31 7.59E-5
12 SGTC_1689 st020265 3.72 53.5 µM 4.05E-5 19 9.92E-5
13 SGTC_2251 lansoprazole 3.60 556.0 µM 6.73E-5 29 1.57E-4
14 SGTC_604 1000-0114 3.59 314.0 µM 7.00E-5 35 1.62E-4
15 SGTC_2041 5107442 3.59 45.3 µM 7.00E-5 RSC complex & mRNA processing 37 1.62E-4
16 SGTC_2615 purpurogallin-4-carboxylic acid 3.58 100.0 µM 7.59E-5 redox potentiating 79 1.75E-4
17 SGTC_2035 5154463 3.51 94.6 µM 1.00E-4 26 2.25E-4
18 SGTC_2243 6634756 3.36 200.0 µM 1.87E-4 38 3.95E-4
19 SGTC_311 1315-0136 3.34 58.0 µM 2.00E-4 26 4.19E-4
20 SGTC_3235 9132602 3.33 49.5 µM 2.09E-4 50 4.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 8.26E-13 YPL082C MOT1 het Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA
0.115 2.99E-11 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.114 3.67E-11 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.110 1.82E-10 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.103 2.38E-9 YDL138W RGT2 hom Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication
0.101 4.62E-9 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.100 7.32E-9 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.097 2.15E-8 YKL089W MIF2 het Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3
0.095 3.18E-8 YMR039C SUB1 hom Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress
0.095 3.51E-8 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 4.64E-8 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.090 2.04E-7 YGR185C TYS1 het Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.087 4.05E-7 YCR008W SAT4 hom Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
0.086 6.52E-7 YDR211W GCD6 het Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
0.086 7.26E-7 YDL149W ATG9 hom Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS