YCL021W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL021W-A / YCL021W-A

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:2.81|P-value:9.08E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.78|P-value:1.36E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.93|P-value:2.34E-11 ID:SGTC_59|Compound:0330-0160|FD-Score:-2.97|P-value:4.78E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.05|P-value:3.49E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.03|P-value:3.78E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.17|P-value:2.08E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.44|P-value:6.66E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:8.45|P-value:3.30E-21 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.31|P-value:1.18E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:2.84|P-value:8.04E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.29|P-value:1.27E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-2.99|P-value:4.45E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.22|P-value:1.75E-4 ID:SGTC_698|Compound:k064-0052|FD-Score:3.27|P-value:1.39E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.96|P-value:5.06E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.42|P-value:7.40E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:2.89|P-value:6.77E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.64|P-value:1.32E-7 ID:SGTC_1687|Compound:st020778|FD-Score:8.56|P-value:9.80E-22 ID:SGTC_1712|Compound:st032288|FD-Score:5.55|P-value:3.56E-10 ID:SGTC_1716|Compound:st033144|FD-Score:3.53|P-value:4.48E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-3.07|P-value:3.19E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.98|P-value:5.07E-6 ID:SGTC_1745|Compound:st081495|FD-Score:3.52|P-value:4.59E-5 ID:SGTC_1748|Compound:st037455|FD-Score:3.19|P-value:2.00E-4 ID:SGTC_1887|Compound:st057648|FD-Score:2.84|P-value:8.00E-4 ID:SGTC_1927|Compound:st060202|FD-Score:2.98|P-value:4.62E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-3.21|P-value:1.76E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-2.83|P-value:8.18E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-3.30|P-value:1.24E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.64|P-value:2.62E-5 ID:SGTC_2180|Compound:6301957|FD-Score:2.79|P-value:9.96E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.94|P-value:2.02E-8 ID:SGTC_2325|Compound:6158266|FD-Score:-2.97|P-value:4.74E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-3.24|P-value:1.58E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.02|P-value:3.98E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-2.92|P-value:5.81E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-2.79|P-value:9.43E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.80|P-value:4.78E-8 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.92|P-value:6.58E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.46|P-value:6.81E-10 ID:SGTC_2976|Compound:9009005|FD-Score:3.11|P-value:2.84E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-3.06|P-value:3.34E-4 ID:SGTC_2983|Compound:9022671|FD-Score:4.19|P-value:1.66E-6 ID:SGTC_3139|Compound:9095020|FD-Score:2.82|P-value:8.75E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:2.81|P-value:9.08E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.78|P-value:1.36E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.93|P-value:2.34E-11 ID:SGTC_59|Compound:0330-0160|FD-Score:-2.97|P-value:4.78E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.05|P-value:3.49E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:3.03|P-value:3.78E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:-3.17|P-value:2.08E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.44|P-value:6.66E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:8.45|P-value:3.30E-21 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.31|P-value:1.18E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:2.84|P-value:8.04E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.29|P-value:1.27E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-2.99|P-value:4.45E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.22|P-value:1.75E-4 ID:SGTC_698|Compound:k064-0052|FD-Score:3.27|P-value:1.39E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.96|P-value:5.06E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:3.42|P-value:7.40E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:2.89|P-value:6.77E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.64|P-value:1.32E-7 ID:SGTC_1687|Compound:st020778|FD-Score:8.56|P-value:9.80E-22 ID:SGTC_1712|Compound:st032288|FD-Score:5.55|P-value:3.56E-10 ID:SGTC_1716|Compound:st033144|FD-Score:3.53|P-value:4.48E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-3.07|P-value:3.19E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.98|P-value:5.07E-6 ID:SGTC_1745|Compound:st081495|FD-Score:3.52|P-value:4.59E-5 ID:SGTC_1748|Compound:st037455|FD-Score:3.19|P-value:2.00E-4 ID:SGTC_1887|Compound:st057648|FD-Score:2.84|P-value:8.00E-4 ID:SGTC_1927|Compound:st060202|FD-Score:2.98|P-value:4.62E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-3.21|P-value:1.76E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-2.83|P-value:8.18E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-3.30|P-value:1.24E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.64|P-value:2.62E-5 ID:SGTC_2180|Compound:6301957|FD-Score:2.79|P-value:9.96E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.94|P-value:2.02E-8 ID:SGTC_2325|Compound:6158266|FD-Score:-2.97|P-value:4.74E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-3.24|P-value:1.58E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-3.02|P-value:3.98E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-2.92|P-value:5.81E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-2.79|P-value:9.43E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.80|P-value:4.78E-8 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.92|P-value:6.58E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.46|P-value:6.81E-10 ID:SGTC_2976|Compound:9009005|FD-Score:3.11|P-value:2.84E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-3.06|P-value:3.34E-4 ID:SGTC_2983|Compound:9022671|FD-Score:4.19|P-value:1.66E-6 ID:SGTC_3139|Compound:9095020|FD-Score:2.82|P-value:8.75E-4

Top fitness defect scores for YCL021W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1687 st020778 8.56 55.4 µM 9.80E-22 59 5.64E-18
2 SGTC_351 caspofungin 8.45 25.0 nM 3.30E-21 cell wall 14 1.51E-17
3 SGTC_58 0957-0393 5.93 9.0 µM 2.34E-11 cell wall 218 1.55E-9
4 SGTC_1712 st032288 5.55 53.4 µM 3.56E-10 calcium & mitochondrial duress 89 1.42E-8
5 SGTC_2688 kanamycin b 5.46 96.7 µM 6.81E-10 calcium & mitochondrial duress 199 2.42E-8
6 SGTC_2316 5844804 4.94 197.4 µM 2.02E-8 9 3.84E-7
7 SGTC_1597 7-benzyloxygramine 4.64 47.5 µM 1.32E-7 calcium & mitochondrial duress 80 1.78E-6
8 SGTC_2983 9022671 4.19 13.0 µM 1.66E-6 60S ribosome export 8 1.40E-5
9 SGTC_1736 st036774 3.98 51.0 µM 5.07E-6 32 3.51E-5
10 SGTC_56 0957-0365 3.78 83.2 µM 1.36E-5 Golgi 53 7.88E-5
11 SGTC_2021 4019055 3.64 173.0 µM 2.62E-5 endomembrane recycling 143 1.35E-4
12 SGTC_1716 st033144 3.53 30.6 µM 4.48E-5 32 2.09E-4
13 SGTC_1745 st081495 3.52 74.0 µM 4.59E-5 RNA processing & uracil transport 92 2.13E-4
14 SGTC_308 4092-1169 3.44 104.0 µM 6.66E-5 plasma membrane duress 71 2.89E-4
15 SGTC_751 0833-0568 3.42 350.0 µM 7.40E-5 41 3.15E-4
16 SGTC_698 k064-0052 3.27 127.0 µM 1.39E-4 DNA damage response 9 5.31E-4
17 SGTC_640 3381-0960 3.22 37.1 µM 1.75E-4 39 6.40E-4
18 SGTC_1748 st037455 3.19 53.6 µM 2.00E-4 71 7.13E-4
19 SGTC_2976 9009005 3.11 19.5 µM 2.84E-4 61 9.51E-4
20 SGTC_146 3448-8650 3.05 53.1 µM 3.49E-4 NEO1-PIK1 215 0.00113

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.290 3.63E-66 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.283 5.82E-63 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.230 1.63E-41 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.228 1.10E-40 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.213 1.13E-35 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.210 1.22E-34 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.201 5.11E-32 YDL213C NOP6 hom rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
0.196 2.66E-30 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.194 1.00E-29 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
0.192 4.05E-29 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.190 1.51E-28 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.188 6.19E-28 YML001W YPT7 hom Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
0.187 9.88E-28 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.185 2.38E-27 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.184 8.81E-27 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication