YCL023C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL023C / YCL023C

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-4.18|P-value:2.38E-6 ID:SGTC_544|Compound:k015-0020|FD-Score:2.99|P-value:6.06E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.50|P-value:6.44E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.07|P-value:3.90E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.10|P-value:3.88E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.44|P-value:9.65E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.90|P-value:7.37E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.28|P-value:4.04E-9 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-4.60|P-value:2.48E-7 ID:SGTC_1280|Compound:0880-0253|FD-Score:-3.14|P-value:2.91E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.52|P-value:6.92E-5 ID:SGTC_1742|Compound:st038235|FD-Score:-3.45|P-value:8.11E-5 ID:SGTC_1746|Compound:st038117|FD-Score:-3.28|P-value:1.67E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.73|P-value:2.23E-5 ID:SGTC_1968|Compound:st069590|FD-Score:3.54|P-value:6.19E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.42|P-value:1.05E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.19|P-value:2.41E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.15|P-value:2.86E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.90|P-value:7.48E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.69|P-value:2.70E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:6.73|P-value:1.33E-13 ID:SGTC_2585|Compound:alliin|FD-Score:-5.12|P-value:1.07E-8 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.92|P-value:3.85E-8 ID:SGTC_2591|Compound:skatole|FD-Score:4.39|P-value:9.68E-7 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.29|P-value:1.57E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.75|P-value:2.00E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-3.48|P-value:7.06E-5 ID:SGTC_2790|Compound:5423970|FD-Score:5.25|P-value:5.98E-9 ID:SGTC_2826|Compound:7992541|FD-Score:2.98|P-value:6.34E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-2.82|P-value:9.82E-4 ID:SGTC_2860|Compound:9025725|FD-Score:-3.19|P-value:2.40E-4 ID:SGTC_2863|Compound:9028737|FD-Score:-3.33|P-value:1.34E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-2.98|P-value:5.42E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.32|P-value:1.62E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.13|P-value:3.51E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-4.20|P-value:2.20E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.18|P-value:2.38E-6 ID:SGTC_544|Compound:k015-0020|FD-Score:2.99|P-value:6.06E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.50|P-value:6.44E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.07|P-value:3.90E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.10|P-value:3.88E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.44|P-value:9.65E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.90|P-value:7.37E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.28|P-value:4.04E-9 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-4.60|P-value:2.48E-7 ID:SGTC_1280|Compound:0880-0253|FD-Score:-3.14|P-value:2.91E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.52|P-value:6.92E-5 ID:SGTC_1742|Compound:st038235|FD-Score:-3.45|P-value:8.11E-5 ID:SGTC_1746|Compound:st038117|FD-Score:-3.28|P-value:1.67E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.73|P-value:2.23E-5 ID:SGTC_1968|Compound:st069590|FD-Score:3.54|P-value:6.19E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.42|P-value:1.05E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.19|P-value:2.41E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.15|P-value:2.86E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.90|P-value:7.48E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.69|P-value:2.70E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:6.73|P-value:1.33E-13 ID:SGTC_2585|Compound:alliin|FD-Score:-5.12|P-value:1.07E-8 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.92|P-value:3.85E-8 ID:SGTC_2591|Compound:skatole|FD-Score:4.39|P-value:9.68E-7 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.29|P-value:1.57E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.75|P-value:2.00E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-3.48|P-value:7.06E-5 ID:SGTC_2790|Compound:5423970|FD-Score:5.25|P-value:5.98E-9 ID:SGTC_2826|Compound:7992541|FD-Score:2.98|P-value:6.34E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-2.82|P-value:9.82E-4 ID:SGTC_2860|Compound:9025725|FD-Score:-3.19|P-value:2.40E-4 ID:SGTC_2863|Compound:9028737|FD-Score:-3.33|P-value:1.34E-4 ID:SGTC_3119|Compound:9125183|FD-Score:-2.98|P-value:5.42E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.32|P-value:1.62E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.13|P-value:3.51E-4 ID:SGTC_3335|Compound:9143315|FD-Score:-4.20|P-value:2.20E-6

Top fitness defect scores for YCL023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2580 diallyl disulphide 6.73 81.4 µM 1.33E-13 3 8.54E-12
2 SGTC_2790 5423970 5.25 71.4 µM 5.98E-9 endomembrane recycling 33 7.56E-8
3 SGTC_2591 skatole 4.39 100.0 µM 9.68E-7 23 5.73E-6
4 SGTC_1968 st069590 3.54 43.6 µM 6.19E-5 20 1.99E-4
5 SGTC_1324 1418-0026 3.52 34.4 µM 6.92E-5 25 2.19E-4
6 SGTC_931 2812-0076 3.44 566.0 µM 9.65E-5 41 2.91E-4
7 SGTC_2057 5236571 3.42 38.3 µM 1.05E-4 RPP1 & pyrimidine depletion 57 3.12E-4
8 SGTC_3302 9125395 3.32 16.4 µM 1.62E-4 35 4.53E-4
9 SGTC_3325 9138760 3.13 55.2 µM 3.51E-4 Golgi 52 8.77E-4
10 SGTC_929 2805-0021 3.10 398.0 µM 3.88E-4 48 9.56E-4
11 SGTC_544 k015-0020 2.99 52.4 µM 6.06E-4 55 0.00140
12 SGTC_2826 7992541 2.98 19.5 µM 6.34E-4 54 0.00146
13 SGTC_1673 st016611 2.82 27.3 µM 0.00115 117 0.00242
14 SGTC_2893 9048488 2.80 26.0 µM 0.00120 fatty acid desaturase (OLE1) 76 0.00253
15 SGTC_6 0844-0013 2.73 19.8 µM 0.00158 260 0.00319
16 SGTC_1819 st053448 2.69 58.6 µM 0.00181 amide catabolism 93 0.00358
17 SGTC_932 2857-0803 2.69 154.0 µM 0.00183 90 0.00361
18 SGTC_1725 st036284 2.66 20.6 µM 0.00200 109 0.00391
19 SGTC_1708 st033234 2.65 31.8 µM 0.00206 73 0.00402
20 SGTC_169 k015-0017 2.63 16.0 µM 0.00220 75 0.00425

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.208 2.89E-34 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.171 1.49E-23 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.165 7.81E-22 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.156 1.05E-19 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.154 2.57E-19 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.153 4.98E-19 YFR039C_p YFR039C_p hom Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces
0.153 6.26E-19 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.151 1.32E-18 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.148 5.80E-18 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.145 3.04E-17 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.143 6.70E-17 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.138 8.05E-16 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.134 7.93E-15 YLR081W GAL2 hom Galactose permease, required for utilization of galactose; also able to transport glucose
0.133 1.33E-14 YLR449W FPR4 hom Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
0.132 2.00E-14 YNL305C BXI1 hom Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p