YCL026C-A / FRM2

Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL026C-A / FRM2

Click on Significant Values for Screen Details ID:SGTC_264|Compound:promethazine|FD-Score:-3.02|P-value:7.17E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.18|P-value:2.99E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.22|P-value:2.59E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-3.17|P-value:4.10E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.13|P-value:4.67E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.57|P-value:5.84E-5 ID:SGTC_680|Compound:0417-1641|FD-Score:-3.55|P-value:8.61E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:7.46|P-value:6.20E-16 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.05|P-value:5.06E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.83|P-value:1.89E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.57|P-value:8.07E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.62|P-value:4.77E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.73|P-value:2.99E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.75|P-value:2.69E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:2.92|P-value:8.14E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.13|P-value:4.77E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-7.16|P-value:1.41E-14 ID:SGTC_1463|Compound:k081-0032|FD-Score:-7.93|P-value:1.64E-17 ID:SGTC_1695|Compound:st026914|FD-Score:4.12|P-value:4.69E-6 ID:SGTC_1737|Compound:st035557|FD-Score:-3.24|P-value:3.07E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.35|P-value:1.49E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.40|P-value:1.25E-4 ID:SGTC_2456|Compound:5770359|FD-Score:2.95|P-value:7.35E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.02|P-value:5.61E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.20|P-value:2.78E-4 ID:SGTC_2827|Compound:7993847|FD-Score:2.92|P-value:7.96E-4 ID:SGTC_2835|Compound:9006588|FD-Score:2.87|P-value:9.67E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.64|P-value:4.45E-5 ID:SGTC_2880|Compound:9042983|FD-Score:4.05|P-value:6.53E-6 ID:SGTC_3193|Compound:9111931|FD-Score:2.95|P-value:7.19E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.41|P-value:1.18E-4 ID:SGTC_3262|Compound:9137218|FD-Score:3.58|P-value:5.78E-5 ID:SGTC_3348|Compound:9149464|FD-Score:-3.14|P-value:4.61E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.02|P-value:7.17E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.18|P-value:2.99E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.22|P-value:2.59E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-3.17|P-value:4.10E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.13|P-value:4.67E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.57|P-value:5.84E-5 ID:SGTC_680|Compound:0417-1641|FD-Score:-3.55|P-value:8.61E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:7.46|P-value:6.20E-16 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.05|P-value:5.06E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.83|P-value:1.89E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.57|P-value:8.07E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.62|P-value:4.77E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.73|P-value:2.99E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.75|P-value:2.69E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:2.92|P-value:8.14E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.13|P-value:4.77E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-7.16|P-value:1.41E-14 ID:SGTC_1463|Compound:k081-0032|FD-Score:-7.93|P-value:1.64E-17 ID:SGTC_1695|Compound:st026914|FD-Score:4.12|P-value:4.69E-6 ID:SGTC_1737|Compound:st035557|FD-Score:-3.24|P-value:3.07E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.35|P-value:1.49E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.40|P-value:1.25E-4 ID:SGTC_2456|Compound:5770359|FD-Score:2.95|P-value:7.35E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.02|P-value:5.61E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.20|P-value:2.78E-4 ID:SGTC_2827|Compound:7993847|FD-Score:2.92|P-value:7.96E-4 ID:SGTC_2835|Compound:9006588|FD-Score:2.87|P-value:9.67E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.64|P-value:4.45E-5 ID:SGTC_2880|Compound:9042983|FD-Score:4.05|P-value:6.53E-6 ID:SGTC_3193|Compound:9111931|FD-Score:2.95|P-value:7.19E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.41|P-value:1.18E-4 ID:SGTC_3262|Compound:9137218|FD-Score:3.58|P-value:5.78E-5 ID:SGTC_3348|Compound:9149464|FD-Score:-3.14|P-value:4.61E-4

Top fitness defect scores for YCL026C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_773 4358-1457 7.46 44.6 µM 6.20E-16 9 4.36E-14
2 SGTC_1695 st026914 4.12 34.5 µM 4.69E-6 16 1.93E-5
3 SGTC_2880 9042983 4.05 58.4 µM 6.53E-6 fatty acid desaturase (OLE1) 21 2.57E-5
4 SGTC_1009 4106-0057 3.83 9.9 µM 1.89E-5 14 6.54E-5
5 SGTC_1209 2323-2347 3.75 50.3 µM 2.69E-5 21 8.88E-5
6 SGTC_1207 2099-0101 3.73 141.0 µM 2.99E-5 23 9.74E-5
7 SGTC_2859 9028643 3.64 45.5 µM 4.45E-5 21 1.38E-4
8 SGTC_1132 3456-3614 3.62 2.5 µM 4.77E-5 tubulin folding & SWR complex 70 1.47E-4
9 SGTC_3262 9137218 3.58 49.5 µM 5.78E-5 4 1.73E-4
10 SGTC_612 0302-0167 3.57 22.4 µM 5.84E-5 copper-dependent oxidative stress 51 1.75E-4
11 SGTC_3259 9138485 3.41 49.5 µM 1.18E-4 25 3.25E-4
12 SGTC_2379 9035213 3.40 200.0 µM 1.25E-4 43 3.42E-4
13 SGTC_1976 st070609 3.35 63.5 µM 1.49E-4 28 3.98E-4
14 SGTC_357 1325-0123 3.22 420.0 µM 2.59E-4 26 6.46E-4
15 SGTC_2817 7995342 3.20 71.4 µM 2.78E-4 49 6.87E-4
16 SGTC_352 k048-0007 3.18 5.1 µM 2.99E-4 ERAD & cell cycle 116 7.33E-4
17 SGTC_1008 4106-0037 3.05 6.0 µM 5.06E-4 PDR1 46 0.00116
18 SGTC_2816 7982706 3.02 58.4 µM 5.61E-4 azole & statin 103 0.00127
19 SGTC_3193 9111931 2.95 49.5 µM 7.19E-4 67 0.00158
20 SGTC_2456 5770359 2.95 74.5 µM 7.35E-4 50 0.00161

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.349 2.31E-96 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.342 1.76E-92 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.338 3.86E-90 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.323 1.55E-81 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.308 1.81E-74 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.299 9.96E-70 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.295 7.03E-68 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.293 3.51E-67 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.269 2.26E-56 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.266 3.14E-55 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.260 1.17E-52 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.260 1.69E-52 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.257 1.74E-51 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.252 2.07E-49 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.251 5.54E-49 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication