YCL034W / LSB5

Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL034W / LSB5

Click on Significant Values for Screen Details ID:SGTC_85|Compound:0868-0259|FD-Score:-3.47|P-value:7.53E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.55|P-value:5.82E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.58|P-value:5.26E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.41|P-value:9.26E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.67|P-value:4.04E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.81|P-value:2.51E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.83|P-value:2.34E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-4.34|P-value:3.63E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.92|P-value:1.71E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.45|P-value:8.23E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.56|P-value:5.72E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.46|P-value:8.05E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.90|P-value:1.86E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.44|P-value:8.22E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.48|P-value:7.45E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-4.05|P-value:1.04E-4 ID:SGTC_3301|Compound:9125354|FD-Score:8.02|P-value:1.19E-13 ID:SGTC_3332|Compound:9141069|FD-Score:3.44|P-value:8.54E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.47|P-value:7.53E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.55|P-value:5.82E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.58|P-value:5.26E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.41|P-value:9.26E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.67|P-value:4.04E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.81|P-value:2.51E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.83|P-value:2.34E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-4.34|P-value:3.63E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.92|P-value:1.71E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.45|P-value:8.23E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.56|P-value:5.72E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.46|P-value:8.05E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.90|P-value:1.86E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.44|P-value:8.22E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.48|P-value:7.45E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-4.05|P-value:1.04E-4 ID:SGTC_3301|Compound:9125354|FD-Score:8.02|P-value:1.19E-13 ID:SGTC_3332|Compound:9141069|FD-Score:3.44|P-value:8.54E-4

Top fitness defect scores for YCL034W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_3301 9125354 8.02 19.8 µM 1.19E-13 1 5.28E-16
2 SGTC_2364 9055074 3.90 200.0 µM 1.86E-4 21 4.85E-5
3 SGTC_1243 0416-0003 3.83 5.7 µM 2.34E-4 PDR1 34 6.38E-5
4 SGTC_1240 0356-0016 3.81 42.1 µM 2.51E-4 mitochondrial response to ROS 40 6.90E-5
5 SGTC_1197 1601-0112 3.67 267.0 µM 4.04E-4 26 1.22E-4
6 SGTC_1612 st002233 3.56 45.4 µM 5.72E-4 28 1.84E-4
7 SGTC_2758 dehydroepiandrosterone 3.48 69.3 µM 7.45E-4 58 2.51E-4
8 SGTC_2357 9067248 3.46 200.0 µM 8.05E-4 37 2.75E-4
9 SGTC_1608 st001473 3.45 40.5 µM 8.23E-4 53 2.83E-4
10 SGTC_3332 9141069 3.44 11.2 µM 8.54E-4 32 2.95E-4
11 SGTC_368 fentichlor 3.41 4.6 µM 9.26E-4 42 3.25E-4
12 SGTC_348 k064-0012 3.37 10.7 µM 0.00106 60S ribosome export 33 3.80E-4
13 SGTC_1819 st053448 3.36 58.6 µM 0.00108 amide catabolism 38 3.91E-4
14 SGTC_293 4049-0273 3.32 38.5 µM 0.00123 29 4.55E-4
15 SGTC_2258 7960471 3.25 200.0 µM 0.00151 30 5.78E-4
16 SGTC_388 3',4'-dichloroisocoumarin 3.12 16.7 µM 0.00220 40 9.05E-4
17 SGTC_3220 9131269 3.10 49.5 µM 0.00234 32 9.75E-4
18 SGTC_1195 1502-0147 3.09 41.1 µM 0.00238 67 9.92E-4
19 SGTC_707 0865-0008 3.08 204.0 µM 0.00245 DNA damage response 29 0.00103
20 SGTC_1092 toremifene 3.05 6.3 µM 0.00267 62 0.00114

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.21E-25 YER082C UTP7 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.130 3.63E-14 YDL028C MPS1 het Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p
0.113 4.86E-11 YPL031C PHO85 hom Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle
0.104 1.67E-9 YPL111W CAR1 hom Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
0.094 4.61E-8 YOR217W RFC1 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.091 1.20E-7 YPL081W RPS9A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication
0.089 2.22E-7 YAL066W_d YAL066W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.089 2.57E-7 YNL145W MFA2 hom Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1
0.088 3.37E-7 YOR013W_d IRC11_d hom Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
0.086 5.89E-7 YPR071W_p YPR071W_p hom Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C
0.085 8.51E-7 YOR352W TFB6 hom Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.084 1.24E-6 YMR315W YMR315W hom Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress
0.083 1.41E-6 YLR209C PNP1 hom Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway
0.083 1.43E-6 YGR279C SCW4 hom Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
0.083 1.66E-6 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress