HIPHOP chemogenomics database
YCL041C_d 
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YCL041C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.148 | 6.70E-18 | YGL015C_p | YGL015C_p | hom | Putative protein of unknown function; null mutants accumulate cargo in the Golgi |
| 0.145 | 2.97E-17 | YAL005C | SSA1 | hom | ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils |
| 0.123 | 7.70E-13 | YMR101C | SRT1 | hom | Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase |
| 0.122 | 1.14E-12 | YER066W_p | RRT13_p | hom | Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription |
| 0.117 | 1.25E-11 | YAR008W | SEN34 | het | Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease |
| 0.113 | 4.79E-11 | YJL064W_d | YJL064W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 |
| 0.112 | 7.09E-11 | YER069W | ARG5,6 | hom | Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine |
| 0.106 | 6.70E-10 | YLR395C | COX8 | hom | Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain |
| 0.104 | 1.33E-9 | YBR294W | SUL1 | hom | High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates |
| 0.104 | 1.34E-9 | YGL257C | MNT2 | hom | Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans |
| 0.104 | 1.82E-9 | YGL146C_p | RRT6_p | hom | Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins |
| 0.103 | 2.29E-9 | YCR102W-A_d | YCR102W-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.100 | 6.04E-9 | YOR300W_d | YOR300W_d | hom | Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 |
| 0.094 | 4.73E-8 | YGR189C | CRH1 | hom | Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress |
| 0.093 | 6.16E-8 | YOR356W | CIR2 | hom | Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response |