YCL044C / MGR1

Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL044C / MGR1

Click on Significant Values for Screen Details ID:SGTC_236|Compound:1509-0011|FD-Score:8.28|P-value:2.59E-18 ID:SGTC_264|Compound:promethazine|FD-Score:-3.35|P-value:2.37E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.42|P-value:1.75E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.15|P-value:4.97E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.02|P-value:7.90E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:5.14|P-value:3.91E-8 ID:SGTC_769|Compound:0302-0231|FD-Score:3.86|P-value:2.67E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:5.73|P-value:1.08E-9 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.94|P-value:1.96E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:3.79|P-value:3.73E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:2.96|P-value:9.87E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-4.35|P-value:2.87E-6 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.84|P-value:2.11E-7 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.56|P-value:9.88E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.06|P-value:1.11E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.04|P-value:7.70E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.44|P-value:1.63E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.28|P-value:3.14E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.04|P-value:7.49E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.16|P-value:4.74E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.13|P-value:5.40E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.40|P-value:1.91E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.35|P-value:2.28E-4 ID:SGTC_2061|Compound:5245884|FD-Score:-3.27|P-value:3.27E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-4.47|P-value:1.56E-6 ID:SGTC_2315|Compound:7733312|FD-Score:3.03|P-value:7.55E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.09|P-value:6.23E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.19|P-value:4.34E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.17|P-value:4.72E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.68|P-value:4.90E-7 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.43|P-value:1.85E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.62|P-value:7.77E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-2.99|P-value:9.04E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.54|P-value:3.58E-9 ID:SGTC_2707|Compound:st078556|FD-Score:-3.34|P-value:2.43E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.03|P-value:7.86E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.46|P-value:5.60E-9 ID:SGTC_2797|Compound:7859098|FD-Score:-7.51|P-value:2.21E-15 ID:SGTC_2798|Compound:7813637|FD-Score:4.13|P-value:7.86E-6 ID:SGTC_2801|Compound:7907800|FD-Score:3.10|P-value:5.88E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.00|P-value:8.48E-4 ID:SGTC_2890|Compound:9046729|FD-Score:-3.41|P-value:1.87E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.17|P-value:6.63E-6 ID:SGTC_2920|Compound:7982904|FD-Score:-5.27|P-value:1.87E-8 ID:SGTC_2924|Compound:9010168|FD-Score:3.58|P-value:9.17E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-5.14|P-value:3.93E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:8.28|P-value:2.59E-18 ID:SGTC_264|Compound:promethazine|FD-Score:-3.35|P-value:2.37E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.42|P-value:1.75E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.15|P-value:4.97E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.02|P-value:7.90E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:5.14|P-value:3.91E-8 ID:SGTC_769|Compound:0302-0231|FD-Score:3.86|P-value:2.67E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:5.73|P-value:1.08E-9 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.94|P-value:1.96E-5 ID:SGTC_842|Compound:0271-0008|FD-Score:3.79|P-value:3.73E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:2.96|P-value:9.87E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-4.35|P-value:2.87E-6 ID:SGTC_1175|Compound:0741-0056|FD-Score:4.84|P-value:2.11E-7 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.56|P-value:9.88E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.06|P-value:1.11E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.04|P-value:7.70E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.44|P-value:1.63E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.28|P-value:3.14E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.04|P-value:7.49E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.16|P-value:4.74E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-3.13|P-value:5.40E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.40|P-value:1.91E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.35|P-value:2.28E-4 ID:SGTC_2061|Compound:5245884|FD-Score:-3.27|P-value:3.27E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-4.47|P-value:1.56E-6 ID:SGTC_2315|Compound:7733312|FD-Score:3.03|P-value:7.55E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.09|P-value:6.23E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.19|P-value:4.34E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.17|P-value:4.72E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.68|P-value:4.90E-7 ID:SGTC_2587|Compound:piperic acid|FD-Score:4.43|P-value:1.85E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.62|P-value:7.77E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-2.99|P-value:9.04E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:5.54|P-value:3.58E-9 ID:SGTC_2707|Compound:st078556|FD-Score:-3.34|P-value:2.43E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.03|P-value:7.86E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.46|P-value:5.60E-9 ID:SGTC_2797|Compound:7859098|FD-Score:-7.51|P-value:2.21E-15 ID:SGTC_2798|Compound:7813637|FD-Score:4.13|P-value:7.86E-6 ID:SGTC_2801|Compound:7907800|FD-Score:3.10|P-value:5.88E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.00|P-value:8.48E-4 ID:SGTC_2890|Compound:9046729|FD-Score:-3.41|P-value:1.87E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.17|P-value:6.63E-6 ID:SGTC_2920|Compound:7982904|FD-Score:-5.27|P-value:1.87E-8 ID:SGTC_2924|Compound:9010168|FD-Score:3.58|P-value:9.17E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-5.14|P-value:3.93E-8

Top fitness defect scores for YCL044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 8.28 5.3 µM 2.59E-18 241 6.33E-17
2 SGTC_795 0685-0265 5.73 78.0 µM 1.08E-9 excess fatty acid 7 5.15E-9
3 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 5.54 100.0 µM 3.58E-9 12 1.54E-8
4 SGTC_2788 5282734 5.46 71.4 µM 5.60E-9 18 2.33E-8
5 SGTC_743 1275-0778 5.14 158.0 µM 3.91E-8 excess fatty acid 18 1.39E-7
6 SGTC_1175 0741-0056 4.84 27.6 µM 2.11E-7 5 6.51E-7
7 SGTC_2582 agaric acid 4.68 100.0 µM 4.90E-7 redox potentiating 245 1.41E-6
8 SGTC_2587 piperic acid 4.43 92.2 µM 1.85E-6 15 4.80E-6
9 SGTC_2917 7979103 4.17 53.8 µM 6.63E-6 24 1.55E-5
10 SGTC_2798 7813637 4.13 45.5 µM 7.86E-6 24 1.81E-5
11 SGTC_1255 0566-0045 4.06 221.0 µM 1.11E-5 excess fatty acid 28 2.48E-5
12 SGTC_769 0302-0231 3.86 76.0 µM 2.67E-5 43 5.58E-5
13 SGTC_842 0271-0008 3.79 11.1 µM 3.73E-5 heme biosynthesis & mitochondrial translocase 22 7.58E-5
14 SGTC_2924 9010168 3.58 62.8 µM 9.17E-5 cell wall signaling 54 1.73E-4
15 SGTC_1181 1222-0449 3.56 220.0 µM 9.88E-5 34 1.86E-4
16 SGTC_1441 4106-0040 3.44 13.0 µM 1.63E-4 18 2.95E-4
17 SGTC_518 1021-0119 3.42 62.6 µM 1.75E-4 ERG2 67 3.15E-4
18 SGTC_1810 st050138 3.40 53.0 µM 1.91E-4 PDR1 22 3.41E-4
19 SGTC_1914 st062367 3.35 72.6 µM 2.28E-4 39 4.01E-4
20 SGTC_1635 st007035 3.16 42.4 µM 4.74E-4 276 7.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.293 2.67E-67 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.285 1.14E-63 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.281 6.37E-62 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.276 1.34E-59 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.269 1.84E-56 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.259 2.46E-52 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.256 3.57E-51 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.254 1.58E-50 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.253 7.03E-50 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.249 2.25E-48 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.248 4.19E-48 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.246 2.89E-47 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.245 5.86E-47 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.235 3.40E-43 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.234 9.87E-43 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress