HIPHOP chemogenomics database

YCL044C / MGR1

Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA

Zygosity: Homozygous strain

fixedexpanded
Profile for YCL044C / MGR1

Click on Significant Values for Screen Details

Top fitness defect scores for YCL044C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	8.28	5.3 µM	2.59E-18		241	6.33E-17
2	SGTC_795	0685-0265	5.73	78.0 µM	1.08E-9	excess fatty acid	7	5.15E-9
3	SGTC_2631	bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone	5.54	100.0 µM	3.58E-9		12	1.54E-8
4	SGTC_2788	5282734	5.46	71.4 µM	5.60E-9		18	2.33E-8
5	SGTC_743	1275-0778	5.14	158.0 µM	3.91E-8	excess fatty acid	18	1.39E-7
6	SGTC_1175	0741-0056	4.84	27.6 µM	2.11E-7		5	6.51E-7
7	SGTC_2582	agaric acid	4.68	100.0 µM	4.90E-7	redox potentiating	245	1.41E-6
8	SGTC_2587	piperic acid	4.43	92.2 µM	1.85E-6		15	4.80E-6
9	SGTC_2917	7979103	4.17	53.8 µM	6.63E-6		24	1.55E-5
10	SGTC_2798	7813637	4.13	45.5 µM	7.86E-6		24	1.81E-5
11	SGTC_1255	0566-0045	4.06	221.0 µM	1.11E-5	excess fatty acid	28	2.48E-5
12	SGTC_769	0302-0231	3.86	76.0 µM	2.67E-5		43	5.58E-5
13	SGTC_842	0271-0008	3.79	11.1 µM	3.73E-5	heme biosynthesis & mitochondrial translocase	22	7.58E-5
14	SGTC_2924	9010168	3.58	62.8 µM	9.17E-5	cell wall signaling	54	1.73E-4
15	SGTC_1181	1222-0449	3.56	220.0 µM	9.88E-5		34	1.86E-4
16	SGTC_1441	4106-0040	3.44	13.0 µM	1.63E-4		18	2.95E-4
17	SGTC_518	1021-0119	3.42	62.6 µM	1.75E-4	ERG2	67	3.15E-4
18	SGTC_1810	st050138	3.40	53.0 µM	1.91E-4	PDR1	22	3.41E-4
19	SGTC_1914	st062367	3.35	72.6 µM	2.28E-4		39	4.01E-4
20	SGTC_1635	st007035	3.16	42.4 µM	4.74E-4		276	7.86E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.293	2.67E-67	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.285	1.14E-63	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.281	6.37E-62	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.276	1.34E-59	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.269	1.84E-56	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.259	2.46E-52	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.256	3.57E-51	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.254	1.58E-50	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.253	7.03E-50	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.249	2.25E-48	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.248	4.19E-48	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.246	2.89E-47	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.245	5.86E-47	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.235	3.40E-43	YKL087C	CYT2	hom	Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.234	9.87E-43	YDR479C	PEX29	hom	Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress