YCL047C / POF1

ATPase involved in the protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; also interacts with Ubc7p

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL047C / POF1

Click on Significant Values for Screen Details ID:SGTC_136|Compound:0097-0015|FD-Score:5.17|P-value:5.48E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.66|P-value:2.73E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.58|P-value:3.59E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.41|P-value:6.60E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.67|P-value:2.67E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:7.68|P-value:2.15E-13 ID:SGTC_872|Compound:0588-0139|FD-Score:7.11|P-value:1.00E-11 ID:SGTC_873|Compound:0591-4978|FD-Score:-5.78|P-value:2.48E-8 ID:SGTC_878|Compound:0828-0289|FD-Score:3.73|P-value:2.15E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.53|P-value:4.34E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.82|P-value:1.58E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.97|P-value:8.93E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.32|P-value:8.58E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.71|P-value:2.35E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.40|P-value:6.70E-4 ID:SGTC_1843|Compound:st055809|FD-Score:4.73|P-value:4.06E-6 ID:SGTC_1909|Compound:st060837|FD-Score:3.73|P-value:2.17E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.41|P-value:6.42E-4 ID:SGTC_2072|Compound:5231554|FD-Score:5.13|P-value:6.54E-7 ID:SGTC_2097|Compound:5376186|FD-Score:-3.52|P-value:4.38E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-3.62|P-value:3.21E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.84|P-value:1.45E-4 ID:SGTC_2267|Compound:7931562|FD-Score:5.16|P-value:5.66E-7 ID:SGTC_2270|Compound:7924575|FD-Score:-4.13|P-value:4.91E-5 ID:SGTC_2272|Compound:7805186|FD-Score:-3.64|P-value:2.94E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.60|P-value:3.43E-4 ID:SGTC_2283|Compound:7944793|FD-Score:5.13|P-value:6.41E-7 ID:SGTC_2286|Compound:7945697|FD-Score:5.32|P-value:2.61E-7 ID:SGTC_2403|Compound:6032726|FD-Score:3.36|P-value:7.74E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.55|P-value:4.01E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.29|P-value:9.63E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.60|P-value:3.40E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-3.59|P-value:3.55E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.74|P-value:2.08E-4 ID:SGTC_2864|Compound:9034755|FD-Score:4.34|P-value:2.14E-5 ID:SGTC_2865|Compound:9030313|FD-Score:3.94|P-value:9.93E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:5.17|P-value:5.48E-7 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.66|P-value:2.73E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.58|P-value:3.59E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.41|P-value:6.60E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.67|P-value:2.67E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:7.68|P-value:2.15E-13 ID:SGTC_872|Compound:0588-0139|FD-Score:7.11|P-value:1.00E-11 ID:SGTC_873|Compound:0591-4978|FD-Score:-5.78|P-value:2.48E-8 ID:SGTC_878|Compound:0828-0289|FD-Score:3.73|P-value:2.15E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.53|P-value:4.34E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.82|P-value:1.58E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.97|P-value:8.93E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.32|P-value:8.58E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.71|P-value:2.35E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.40|P-value:6.70E-4 ID:SGTC_1843|Compound:st055809|FD-Score:4.73|P-value:4.06E-6 ID:SGTC_1909|Compound:st060837|FD-Score:3.73|P-value:2.17E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.41|P-value:6.42E-4 ID:SGTC_2072|Compound:5231554|FD-Score:5.13|P-value:6.54E-7 ID:SGTC_2097|Compound:5376186|FD-Score:-3.52|P-value:4.38E-4 ID:SGTC_2160|Compound:5660466|FD-Score:-3.62|P-value:3.21E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.84|P-value:1.45E-4 ID:SGTC_2267|Compound:7931562|FD-Score:5.16|P-value:5.66E-7 ID:SGTC_2270|Compound:7924575|FD-Score:-4.13|P-value:4.91E-5 ID:SGTC_2272|Compound:7805186|FD-Score:-3.64|P-value:2.94E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.60|P-value:3.43E-4 ID:SGTC_2283|Compound:7944793|FD-Score:5.13|P-value:6.41E-7 ID:SGTC_2286|Compound:7945697|FD-Score:5.32|P-value:2.61E-7 ID:SGTC_2403|Compound:6032726|FD-Score:3.36|P-value:7.74E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.55|P-value:4.01E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.29|P-value:9.63E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.60|P-value:3.40E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-3.59|P-value:3.55E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-3.74|P-value:2.08E-4 ID:SGTC_2864|Compound:9034755|FD-Score:4.34|P-value:2.14E-5 ID:SGTC_2865|Compound:9030313|FD-Score:3.94|P-value:9.93E-5

Top fitness defect scores for YCL047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_865 0488-0499 7.68 301.0 µM 2.15E-13 3 7.96E-15
2 SGTC_872 0588-0139 7.11 234.0 µM 1.00E-11 2 5.90E-13
3 SGTC_2286 7945697 5.32 125.0 µM 2.61E-7 25 5.22E-8
4 SGTC_136 0097-0015 5.17 404.5 µM 5.48E-7 60S ribosome export 4 1.19E-7
5 SGTC_2267 7931562 5.16 200.0 µM 5.66E-7 3 1.24E-7
6 SGTC_2283 7944793 5.13 200.0 µM 6.41E-7 16 1.42E-7
7 SGTC_2072 5231554 5.13 129.0 µM 6.54E-7 4 1.46E-7
8 SGTC_1843 st055809 4.73 45.5 µM 4.06E-6 8 1.12E-6
9 SGTC_2864 9034755 4.34 47.6 µM 2.14E-5 4 7.20E-6
10 SGTC_1473 k844-0725 3.97 134.0 µM 8.93E-5 11 3.55E-5
11 SGTC_2865 9030313 3.94 52.0 µM 9.93E-5 14 4.00E-5
12 SGTC_2264 7948757 3.84 110.8 µM 1.45E-4 16 6.12E-5
13 SGTC_1134 3477-0009 3.82 42.5 µM 1.58E-4 50 6.70E-5
14 SGTC_878 0828-0289 3.73 13.7 µM 2.15E-4 56 9.46E-5
15 SGTC_1909 st060837 3.73 51.5 µM 2.17E-4 63 9.55E-5
16 SGTC_1627 st003713 3.71 25.6 µM 2.35E-4 calcium & mitochondrial duress 89 1.04E-4
17 SGTC_565 1418-0001 3.67 44.5 µM 2.67E-4 28 1.21E-4
18 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 3.60 66.7 µM 3.40E-4 37 1.58E-4
19 SGTC_2424 5537928 3.55 59.2 µM 4.01E-4 48 1.90E-4
20 SGTC_1011 4112-3381 3.53 17.4 µM 4.34E-4 58 2.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.084 9.73E-7 YCL002C_p YCL002C_p hom Putative protein of unknown function; YCL002C is not an essential gene
0.079 4.22E-6 YMR090W_p YMR090W_p hom Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability
0.078 5.37E-6 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.078 5.46E-6 YLR082C SRL2 hom Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
0.078 6.92E-6 YNL324W_d YNL324W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.075 1.32E-5 YML115C VAN1 hom Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
0.074 1.83E-5 YHR064C SSZ1 hom Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.074 1.86E-5 YOL149W DCP1 het Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
0.073 2.15E-5 YHR167W THP2 hom Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
0.072 2.72E-5 YDR472W TRS31 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.072 3.10E-5 YCR100C_p YCR100C_p hom Putative protein of unknown function
0.072 3.25E-5 YNL014W HEF3 hom Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication
0.071 3.44E-5 YBR226C_d YBR226C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W
0.071 4.27E-5 YKL007W CAP1 hom Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress
0.070 4.53E-5 YCL001W RER1 hom Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER