YCL048W / SPS22

Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL048W / SPS22

Click on Significant Values for Screen Details ID:SGTC_406|Compound:estrone|FD-Score:3.05|P-value:8.36E-4 ID:SGTC_500|Compound:h-89|FD-Score:-3.56|P-value:1.16E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.59|P-value:1.02E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.95|P-value:2.17E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:4.00|P-value:1.86E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.28|P-value:3.49E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:5.58|P-value:4.44E-9 ID:SGTC_916|Compound:4466-0038|FD-Score:4.33|P-value:4.13E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.82|P-value:9.58E-10 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.32|P-value:3.10E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.78|P-value:4.99E-5 ID:SGTC_1636|Compound:st007707|FD-Score:-3.31|P-value:3.09E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.52|P-value:1.44E-4 ID:SGTC_1859|Compound:st055998|FD-Score:6.63|P-value:4.17E-12 ID:SGTC_1981|Compound:st071826|FD-Score:3.01|P-value:9.61E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.68|P-value:7.64E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-3.53|P-value:1.31E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.33|P-value:3.01E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.34|P-value:2.71E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.36|P-value:2.66E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.24|P-value:4.00E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.80|P-value:4.21E-5 ID:SGTC_2918|Compound:7977171|FD-Score:4.18|P-value:8.39E-6 ID:SGTC_2947|Compound:9072639|FD-Score:-3.35|P-value:2.64E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.58|P-value:1.15E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.68|P-value:6.93E-5 ID:SGTC_3227|Compound:9130768|FD-Score:-3.23|P-value:4.13E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.05|P-value:8.36E-4 ID:SGTC_500|Compound:h-89|FD-Score:-3.56|P-value:1.16E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.59|P-value:1.02E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.95|P-value:2.17E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:4.00|P-value:1.86E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.28|P-value:3.49E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:5.58|P-value:4.44E-9 ID:SGTC_916|Compound:4466-0038|FD-Score:4.33|P-value:4.13E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:5.82|P-value:9.58E-10 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.32|P-value:3.10E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.78|P-value:4.99E-5 ID:SGTC_1636|Compound:st007707|FD-Score:-3.31|P-value:3.09E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.52|P-value:1.44E-4 ID:SGTC_1859|Compound:st055998|FD-Score:6.63|P-value:4.17E-12 ID:SGTC_1981|Compound:st071826|FD-Score:3.01|P-value:9.61E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.68|P-value:7.64E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-3.53|P-value:1.31E-4 ID:SGTC_2172|Compound:5754775|FD-Score:3.33|P-value:3.01E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.34|P-value:2.71E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.36|P-value:2.66E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.24|P-value:4.00E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.80|P-value:4.21E-5 ID:SGTC_2918|Compound:7977171|FD-Score:4.18|P-value:8.39E-6 ID:SGTC_2947|Compound:9072639|FD-Score:-3.35|P-value:2.64E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.58|P-value:1.15E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.68|P-value:6.93E-5 ID:SGTC_3227|Compound:9130768|FD-Score:-3.23|P-value:4.13E-4

Top fitness defect scores for YCL048W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1859 st055998 6.63 20.0 µM 4.17E-12 4 1.72E-11
2 SGTC_1045 1348-1485 5.82 165.0 µM 9.58E-10 5 2.86E-9
3 SGTC_913 3487-1245 5.58 167.0 µM 4.44E-9 3 1.21E-8
4 SGTC_916 4466-0038 4.33 42.0 nM 4.13E-6 cell wall 55 7.57E-6
5 SGTC_2918 7977171 4.18 22.1 µM 8.39E-6 23 1.48E-5
6 SGTC_684 1140-0066 4.00 328.0 µM 1.86E-5 Golgi 21 3.13E-5
7 SGTC_1602 st001878 3.78 87.6 µM 4.99E-5 20 7.94E-5
8 SGTC_2121 5257820 3.68 149.6 µM 7.64E-5 14 1.19E-4
9 SGTC_2977 9011197 3.58 71.4 µM 1.15E-4 27 1.74E-4
10 SGTC_1732 st034308 3.52 51.8 µM 1.44E-4 37 2.16E-4
11 SGTC_2435 5706476 3.36 10.6 µM 2.66E-4 41 3.84E-4
12 SGTC_2172 5754775 3.33 163.9 µM 3.01E-4 33 4.33E-4
13 SGTC_1125 tnp00248 3.32 1.3 µM 3.10E-4 67 4.45E-4
14 SGTC_406 estrone 3.05 100.0 µM 8.36E-4 36 0.00113
15 SGTC_1981 st071826 3.01 47.0 µM 9.61E-4 47 0.00129
16 SGTC_1046 2001-0062 3.00 216.0 µM 0.00101 50 0.00136
17 SGTC_1972 st070201 2.97 17.4 µM 0.00110 61 0.00147
18 SGTC_2089 5281248 2.89 129.7 µM 0.00148 superoxide 73 0.00195
19 SGTC_2941 9056145 2.87 11.2 µM 0.00156 50 0.00205
20 SGTC_2001 4023502 2.86 57.7 µM 0.00164 mitochondrial processes 87 0.00215

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 9.18E-16 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.120 2.92E-12 YDR053W_d YDR053W_d het Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex
0.118 7.14E-12 YPL085W SEC16 het COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
0.111 1.29E-10 YLR452C SST2 hom GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
0.107 4.88E-10 YOR361C PRT1 het eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
0.103 1.99E-9 YIL145C PAN6 hom Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
0.097 1.87E-8 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.097 1.83E-8 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.095 3.95E-8 YDR391C_p YDR391C_p hom Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.092 1.05E-7 YDR198C RKM2 hom Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp
0.091 1.30E-7 YPL081W RPS9A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication
0.090 1.90E-7 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.087 3.94E-7 YNL039W BDP1 het Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
0.086 5.62E-7 YPR201W ARR3 hom Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
0.082 1.82E-6 YPR053C_d YPR053C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C