HIPHOP chemogenomics database

YCL076W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YCL076W / YCL076W

Click on Significant Values for Screen Details

Top fitness defect scores for YCL076W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3314	9135860	4.22	59.4 µM	8.63E-7		10	1.24E-5
2	SGTC_1630	st005209	4.17	31.3 µM	1.12E-6		19	1.52E-5
3	SGTC_2316	5844804	4.00	197.4 µM	2.83E-6		28	3.16E-5
4	SGTC_669	0108-0021	3.89	26.2 µM	5.14E-6	fatty acid desaturase (OLE1)	85	5.07E-5
5	SGTC_2693	st077581	3.87	40.7 µM	5.71E-6		36	5.51E-5
6	SGTC_2107	5363541	3.65	170.2 µM	1.71E-5		15	1.31E-4
7	SGTC_916	4466-0038	3.50	42.0 nM	3.57E-5	cell wall	92	2.34E-4
8	SGTC_2808	7946468	3.43	45.5 µM	4.89E-5		45	3.00E-4
9	SGTC_2839	9003951	3.40	26.0 µM	5.60E-5		24	3.34E-4
10	SGTC_3313	9133968	3.36	57.0 µM	6.89E-5		15	3.94E-4
11	SGTC_1350	1495-0454	3.30	146.0 µM	9.03E-5		57	4.88E-4
12	SGTC_1714	st033236	3.29	13.6 µM	9.18E-5		49	4.94E-4
13	SGTC_623	k072-0108	3.24	16.9 µM	1.17E-4	heme biosynthesis & mitochondrial translocase	48	6.00E-4
14	SGTC_910	3454-3003	3.22	490.0 µM	1.30E-4		45	6.50E-4
15	SGTC_2103	5378138	3.20	10.0 µM	1.41E-4		47	6.95E-4
16	SGTC_1924	st058459	3.18	75.1 µM	1.54E-4		32	7.45E-4
17	SGTC_996	3970-0799	3.16	1.8 µM	1.64E-4		139	7.80E-4
18	SGTC_2798	7813637	3.13	45.5 µM	1.86E-4		69	8.63E-4
19	SGTC_1346	1488-2224	3.05	62.4 µM	2.63E-4		47	0.00114
20	SGTC_1984	st072354	3.02	53.1 µM	2.97E-4		44	0.00125

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.312	1.03E-76	YBR207W	FTH1	hom	Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.245	2.94E-47	YOR037W	CYC2	hom	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.242	8.00E-46	YBR084W	MIS1	hom	Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.235	1.61E-43	YDR122W	KIN1	hom	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.228	1.02E-40	YBL066C	SEF1	hom	Putative transcription factor, has homolog in Kluyveromyces lactis
0.215	2.19E-36	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.214	5.40E-36	YDR339C	FCF1	het	Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.206	1.99E-33	YDR505C	PSP1	hom	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.202	3.28E-32	YLR346C_p	YLR346C_p	hom	Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
0.201	6.62E-32	YML081C-A	ATP18	hom	Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
0.199	3.74E-31	YNL011C_p	YNL011C_p	hom	Putative protein of unknown function; YNL011C is not an essential gene
0.195	5.38E-30	YDL133C-A	RPL41B	hom	Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.192	3.15E-29	YDR411C	DFM1	hom	Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.189	2.36E-28	YBR262C	AIM5	hom	Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.189	2.59E-28	YMR139W	RIM11	hom	Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress