YCL076W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YCL076W / YCL076W

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:2.82|P-value:6.86E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-2.78|P-value:8.88E-4 ID:SGTC_57|Compound:miconazole|FD-Score:2.76|P-value:8.63E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.97|P-value:4.27E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.21|P-value:1.57E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-5.78|P-value:3.74E-11 ID:SGTC_404|Compound:fumagillin|FD-Score:-4.34|P-value:5.28E-7 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-4.88|P-value:1.91E-8 ID:SGTC_417|Compound:st075190|FD-Score:2.93|P-value:4.44E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-2.78|P-value:8.93E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-4.42|P-value:3.31E-7 ID:SGTC_488|Compound:nitrendipine|FD-Score:2.76|P-value:8.66E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:-2.77|P-value:9.34E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:2.78|P-value:7.87E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.77|P-value:1.13E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:2.86|P-value:5.68E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.24|P-value:1.17E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-2.92|P-value:5.23E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.89|P-value:5.14E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:-4.19|P-value:1.22E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:3.22|P-value:1.30E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.50|P-value:3.57E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.16|P-value:1.64E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:2.98|P-value:3.60E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.84|P-value:2.40E-11 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.79|P-value:7.66E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.05|P-value:2.63E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:2.83|P-value:6.51E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.30|P-value:9.03E-5 ID:SGTC_1630|Compound:st005209|FD-Score:4.17|P-value:1.12E-6 ID:SGTC_1633|Compound:st005664|FD-Score:-3.13|P-value:2.18E-4 ID:SGTC_1636|Compound:st007707|FD-Score:2.92|P-value:4.55E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.13|P-value:2.18E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-2.84|P-value:7.17E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.29|P-value:9.18E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-4.30|P-value:6.67E-7 ID:SGTC_1924|Compound:st058459|FD-Score:3.18|P-value:1.54E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.02|P-value:2.97E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.20|P-value:1.41E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.65|P-value:1.71E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.82|P-value:6.85E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.00|P-value:2.83E-6 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-2.85|P-value:6.76E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.87|P-value:5.71E-6 ID:SGTC_2798|Compound:7813637|FD-Score:3.13|P-value:1.86E-4 ID:SGTC_2799|Compound:7812892|FD-Score:2.85|P-value:5.93E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.43|P-value:4.89E-5 ID:SGTC_2809|Compound:7964133|FD-Score:2.76|P-value:8.38E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.40|P-value:5.60E-5 ID:SGTC_2847|Compound:9005661|FD-Score:2.83|P-value:6.42E-4 ID:SGTC_2898|Compound:9056270|FD-Score:2.95|P-value:3.95E-4 ID:SGTC_2963|Compound:9082507|FD-Score:2.77|P-value:8.35E-4 ID:SGTC_3297|Compound:9117502|FD-Score:2.79|P-value:7.68E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.82|P-value:8.79E-6 ID:SGTC_3305|Compound:9127027|FD-Score:-2.83|P-value:7.27E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.36|P-value:6.89E-5 ID:SGTC_3314|Compound:9135860|FD-Score:4.22|P-value:8.63E-7 ID:SGTC_3328|Compound:9140624|FD-Score:2.92|P-value:4.45E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:2.82|P-value:6.86E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-2.78|P-value:8.88E-4 ID:SGTC_57|Compound:miconazole|FD-Score:2.76|P-value:8.63E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-2.97|P-value:4.27E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.21|P-value:1.57E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-5.78|P-value:3.74E-11 ID:SGTC_404|Compound:fumagillin|FD-Score:-4.34|P-value:5.28E-7 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-4.88|P-value:1.91E-8 ID:SGTC_417|Compound:st075190|FD-Score:2.93|P-value:4.44E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:-2.78|P-value:8.93E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-4.42|P-value:3.31E-7 ID:SGTC_488|Compound:nitrendipine|FD-Score:2.76|P-value:8.66E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:-2.77|P-value:9.34E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:2.78|P-value:7.87E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.77|P-value:1.13E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:2.86|P-value:5.68E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.24|P-value:1.17E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-2.92|P-value:5.23E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.89|P-value:5.14E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:-4.19|P-value:1.22E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:3.22|P-value:1.30E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.50|P-value:3.57E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.16|P-value:1.64E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:2.98|P-value:3.60E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.84|P-value:2.40E-11 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.79|P-value:7.66E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.05|P-value:2.63E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:2.83|P-value:6.51E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.30|P-value:9.03E-5 ID:SGTC_1630|Compound:st005209|FD-Score:4.17|P-value:1.12E-6 ID:SGTC_1633|Compound:st005664|FD-Score:-3.13|P-value:2.18E-4 ID:SGTC_1636|Compound:st007707|FD-Score:2.92|P-value:4.55E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.13|P-value:2.18E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-2.84|P-value:7.17E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.29|P-value:9.18E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-4.30|P-value:6.67E-7 ID:SGTC_1924|Compound:st058459|FD-Score:3.18|P-value:1.54E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.02|P-value:2.97E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.20|P-value:1.41E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.65|P-value:1.71E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.82|P-value:6.85E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.00|P-value:2.83E-6 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-2.85|P-value:6.76E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.87|P-value:5.71E-6 ID:SGTC_2798|Compound:7813637|FD-Score:3.13|P-value:1.86E-4 ID:SGTC_2799|Compound:7812892|FD-Score:2.85|P-value:5.93E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.43|P-value:4.89E-5 ID:SGTC_2809|Compound:7964133|FD-Score:2.76|P-value:8.38E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.40|P-value:5.60E-5 ID:SGTC_2847|Compound:9005661|FD-Score:2.83|P-value:6.42E-4 ID:SGTC_2898|Compound:9056270|FD-Score:2.95|P-value:3.95E-4 ID:SGTC_2963|Compound:9082507|FD-Score:2.77|P-value:8.35E-4 ID:SGTC_3297|Compound:9117502|FD-Score:2.79|P-value:7.68E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.82|P-value:8.79E-6 ID:SGTC_3305|Compound:9127027|FD-Score:-2.83|P-value:7.27E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.36|P-value:6.89E-5 ID:SGTC_3314|Compound:9135860|FD-Score:4.22|P-value:8.63E-7 ID:SGTC_3328|Compound:9140624|FD-Score:2.92|P-value:4.45E-4

Top fitness defect scores for YCL076W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3314 9135860 4.22 59.4 µM 8.63E-7 10 1.24E-5
2 SGTC_1630 st005209 4.17 31.3 µM 1.12E-6 19 1.52E-5
3 SGTC_2316 5844804 4.00 197.4 µM 2.83E-6 28 3.16E-5
4 SGTC_669 0108-0021 3.89 26.2 µM 5.14E-6 fatty acid desaturase (OLE1) 85 5.07E-5
5 SGTC_2693 st077581 3.87 40.7 µM 5.71E-6 36 5.51E-5
6 SGTC_2107 5363541 3.65 170.2 µM 1.71E-5 15 1.31E-4
7 SGTC_916 4466-0038 3.50 42.0 nM 3.57E-5 cell wall 92 2.34E-4
8 SGTC_2808 7946468 3.43 45.5 µM 4.89E-5 45 3.00E-4
9 SGTC_2839 9003951 3.40 26.0 µM 5.60E-5 24 3.34E-4
10 SGTC_3313 9133968 3.36 57.0 µM 6.89E-5 15 3.94E-4
11 SGTC_1350 1495-0454 3.30 146.0 µM 9.03E-5 57 4.88E-4
12 SGTC_1714 st033236 3.29 13.6 µM 9.18E-5 49 4.94E-4
13 SGTC_623 k072-0108 3.24 16.9 µM 1.17E-4 heme biosynthesis & mitochondrial translocase 48 6.00E-4
14 SGTC_910 3454-3003 3.22 490.0 µM 1.30E-4 45 6.50E-4
15 SGTC_2103 5378138 3.20 10.0 µM 1.41E-4 47 6.95E-4
16 SGTC_1924 st058459 3.18 75.1 µM 1.54E-4 32 7.45E-4
17 SGTC_996 3970-0799 3.16 1.8 µM 1.64E-4 139 7.80E-4
18 SGTC_2798 7813637 3.13 45.5 µM 1.86E-4 69 8.63E-4
19 SGTC_1346 1488-2224 3.05 62.4 µM 2.63E-4 47 0.00114
20 SGTC_1984 st072354 3.02 53.1 µM 2.97E-4 44 0.00125

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.312 1.03E-76 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.245 2.94E-47 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.242 8.00E-46 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.235 1.61E-43 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.228 1.02E-40 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.215 2.19E-36 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.214 5.40E-36 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.206 1.99E-33 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.202 3.28E-32 YLR346C_p YLR346C_p hom Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
0.201 6.62E-32 YML081C-A ATP18 hom Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
0.199 3.74E-31 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.195 5.38E-30 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.192 3.15E-29 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.189 2.36E-28 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.189 2.59E-28 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress