YCR012W / PGK1

3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YCR012W / PGK1

Click on Significant Values for Screen Details ID:SGTC_127|Compound:0180-0333|FD-Score:-3.01|P-value:1.11E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:2.81|P-value:2.52E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.10|P-value:6.21E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.00|P-value:1.16E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.63|P-value:6.14E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:2.79|P-value:2.70E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.60|P-value:4.09E-6 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.90|P-value:1.66E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:-2.77|P-value:3.30E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:2.79|P-value:2.69E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.42|P-value:2.26E-8 ID:SGTC_1524|Compound:corynanthine|FD-Score:2.75|P-value:3.20E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.62|P-value:3.74E-6 ID:SGTC_1705|Compound:st027868|FD-Score:3.24|P-value:3.01E-5 ID:SGTC_1716|Compound:st033144|FD-Score:2.79|P-value:2.66E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.38|P-value:1.42E-5 ID:SGTC_1898|Compound:st060199|FD-Score:-3.11|P-value:6.51E-5 ID:SGTC_1910|Compound:st062352|FD-Score:-2.75|P-value:3.64E-4 ID:SGTC_2167|Compound:5876490|FD-Score:2.88|P-value:1.83E-4 ID:SGTC_2176|Compound:5809774|FD-Score:2.50|P-value:9.65E-4 ID:SGTC_2246|Compound:7293507|FD-Score:2.68|P-value:4.37E-4 ID:SGTC_2292|Compound:7671323|FD-Score:2.67|P-value:4.69E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:2.60|P-value:6.25E-4 ID:SGTC_2443|Compound:5493264|FD-Score:2.74|P-value:3.39E-4 ID:SGTC_2445|Compound:5742597|FD-Score:2.84|P-value:2.19E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.82|P-value:1.23E-9 ID:SGTC_2794|Compound:7785382|FD-Score:2.86|P-value:1.99E-4 ID:SGTC_2800|Compound:7887935|FD-Score:2.73|P-value:3.61E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.19|P-value:4.33E-5 ID:SGTC_2851|Compound:9015922|FD-Score:2.95|P-value:1.27E-4 ID:SGTC_2852|Compound:9023854|FD-Score:2.56|P-value:7.54E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.03|P-value:8.88E-5 ID:SGTC_2867|Compound:9039098|FD-Score:2.92|P-value:1.47E-4 ID:SGTC_2932|Compound:9016711|FD-Score:2.65|P-value:5.00E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-2.73|P-value:4.05E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-2.82|P-value:2.72E-4 ID:SGTC_3096|Compound:9117468|FD-Score:2.73|P-value:3.61E-4 ID:SGTC_3188|Compound:9110789|FD-Score:2.67|P-value:4.66E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.33|P-value:1.84E-5 ID:SGTC_3326|Compound:9140064|FD-Score:-2.86|P-value:2.20E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.01|P-value:1.11E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:2.81|P-value:2.52E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.10|P-value:6.21E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.00|P-value:1.16E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.63|P-value:6.14E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:2.79|P-value:2.70E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.60|P-value:4.09E-6 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.90|P-value:1.66E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:-2.77|P-value:3.30E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:2.79|P-value:2.69E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.42|P-value:2.26E-8 ID:SGTC_1524|Compound:corynanthine|FD-Score:2.75|P-value:3.20E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.62|P-value:3.74E-6 ID:SGTC_1705|Compound:st027868|FD-Score:3.24|P-value:3.01E-5 ID:SGTC_1716|Compound:st033144|FD-Score:2.79|P-value:2.66E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.38|P-value:1.42E-5 ID:SGTC_1898|Compound:st060199|FD-Score:-3.11|P-value:6.51E-5 ID:SGTC_1910|Compound:st062352|FD-Score:-2.75|P-value:3.64E-4 ID:SGTC_2167|Compound:5876490|FD-Score:2.88|P-value:1.83E-4 ID:SGTC_2176|Compound:5809774|FD-Score:2.50|P-value:9.65E-4 ID:SGTC_2246|Compound:7293507|FD-Score:2.68|P-value:4.37E-4 ID:SGTC_2292|Compound:7671323|FD-Score:2.67|P-value:4.69E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:2.60|P-value:6.25E-4 ID:SGTC_2443|Compound:5493264|FD-Score:2.74|P-value:3.39E-4 ID:SGTC_2445|Compound:5742597|FD-Score:2.84|P-value:2.19E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.82|P-value:1.23E-9 ID:SGTC_2794|Compound:7785382|FD-Score:2.86|P-value:1.99E-4 ID:SGTC_2800|Compound:7887935|FD-Score:2.73|P-value:3.61E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.19|P-value:4.33E-5 ID:SGTC_2851|Compound:9015922|FD-Score:2.95|P-value:1.27E-4 ID:SGTC_2852|Compound:9023854|FD-Score:2.56|P-value:7.54E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.03|P-value:8.88E-5 ID:SGTC_2867|Compound:9039098|FD-Score:2.92|P-value:1.47E-4 ID:SGTC_2932|Compound:9016711|FD-Score:2.65|P-value:5.00E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-2.73|P-value:4.05E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-2.82|P-value:2.72E-4 ID:SGTC_3096|Compound:9117468|FD-Score:2.73|P-value:3.61E-4 ID:SGTC_3188|Compound:9110789|FD-Score:2.67|P-value:4.66E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.33|P-value:1.84E-5 ID:SGTC_3326|Compound:9140064|FD-Score:-2.86|P-value:2.20E-4

Top fitness defect scores for YCR012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2691 st077356 4.82 60.2 µM 1.23E-9 5 7.15E-7 0.07
2 SGTC_1263 0774-1208 4.42 64.8 µM 2.26E-8 1 4.95E-6 0.45
3 SGTC_1600 coumarin 106 3.62 71.1 µM 3.74E-6 5 1.49E-4 0.19
4 SGTC_1032 k061-1018 3.60 98.7 µM 4.09E-6 11 1.58E-4 0.22
5 SGTC_1736 st036774 3.38 51.0 µM 1.42E-5 6 3.63E-4 0.04
6 SGTC_3303 9125618 3.33 40.6 µM 1.84E-5 16 4.32E-4 0.11
7 SGTC_1705 st027868 3.24 56.3 µM 3.01E-5 6 6.01E-4 0.06
8 SGTC_390 dec-rvkr-cmk 3.10 16.7 µM 6.21E-5 calcium & mitochondrial duress 19 9.77E-4 0.05
9 SGTC_2856 9022925 3.03 19.5 µM 8.88E-5 16 0.00124 0.03
10 SGTC_2851 9015922 2.95 71.4 µM 1.27E-4 17 0.00158 0.06
11 SGTC_2867 9039098 2.92 71.4 µM 1.47E-4 iron homeostasis 23 0.00174 0.15
12 SGTC_1039 k821-0043 2.90 94.0 µM 1.66E-4 Golgi 15 0.00189 0.07
13 SGTC_2167 5876490 2.88 200.0 µM 1.83E-4 8 0.00202 9.66E-4
14 SGTC_2794 7785382 2.86 27.3 µM 1.99E-4 33 0.00214 0.02
15 SGTC_2445 5742597 2.84 35.6 µM 2.19E-4 23 0.00228 0.02
16 SGTC_161 4065-0411 2.81 162.2 µM 2.52E-4 35 0.00251 0.05
17 SGTC_1716 st033144 2.79 30.6 µM 2.66E-4 21 0.00260 0.01
18 SGTC_1237 0330-0133 2.79 46.1 µM 2.69E-4 ergosterol biosynthesis 26 0.00262 0.01
19 SGTC_879 0831-1030 2.79 162.0 µM 2.70E-4 41 0.00262 0.03
20 SGTC_1524 corynanthine 2.75 62.1 µM 3.20E-4 26 0.00295 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.202 3.15E-32 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.171 2.26E-23 YPR052C NHP6A hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.143 9.97E-17 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.141 2.70E-16 YJL212C OPT1 hom Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
0.133 9.36E-15 YER002W NOP16 hom Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.131 2.29E-14 YML076C WAR1 hom Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
0.126 2.25E-13 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.116 1.32E-11 YOL047C_p YOL047C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.108 2.93E-10 YFR012W-A_p YFR012W-A_p hom Putative protein of unknown function; identified by homology
0.108 3.05E-10 YGR094W VAS1 het Mitochondrial and cytoplasmic valyl-tRNA synthetase
0.106 6.34E-10 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.105 1.06E-9 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.103 1.92E-9 YDR333C RQC1 hom Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC
0.103 2.46E-9 YHR001W OSH7 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.100 5.66E-9 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud