YCR013C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant

Zygosity: Heterozygous strain
fixedexpanded
Profile for YCR013C / YCR013C

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:-4.61|P-value:1.37E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:3.84|P-value:1.25E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:2.82|P-value:9.97E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-5.24|P-value:2.64E-9 ID:SGTC_549|Compound:1661-1316|FD-Score:2.91|P-value:7.29E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:6.53|P-value:3.03E-13 ID:SGTC_599|Compound:1935-0052|FD-Score:2.97|P-value:5.71E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.03|P-value:4.51E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.01|P-value:5.30E-6 ID:SGTC_678|Compound:1218-2179|FD-Score:-2.77|P-value:9.42E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.13|P-value:2.30E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.02|P-value:3.66E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:2.85|P-value:8.97E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:2.91|P-value:7.28E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:-3.11|P-value:2.51E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:-4.46|P-value:3.34E-7 ID:SGTC_1264|Compound:0783-0040|FD-Score:2.88|P-value:7.92E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:-3.04|P-value:3.28E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.07|P-value:3.90E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:-2.82|P-value:8.01E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.17|P-value:2.53E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.70|P-value:2.39E-5 ID:SGTC_1934|Compound:st074720|FD-Score:4.23|P-value:1.69E-6 ID:SGTC_1943|Compound:st076331|FD-Score:-2.77|P-value:9.60E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-2.79|P-value:8.96E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.84|P-value:9.05E-6 ID:SGTC_2261|Compound:9010538|FD-Score:-2.87|P-value:6.58E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-2.86|P-value:6.69E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.09|P-value:3.54E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.08|P-value:2.89E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.09|P-value:3.61E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-2.85|P-value:7.19E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.11|P-value:3.23E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.23|P-value:1.98E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.84|P-value:8.99E-6 ID:SGTC_2811|Compound:7967822|FD-Score:-2.92|P-value:5.29E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-2.77|P-value:9.56E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-4.26|P-value:1.00E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-2.80|P-value:8.49E-4 ID:SGTC_2875|Compound:9039966|FD-Score:-4.07|P-value:2.72E-6 ID:SGTC_2888|Compound:9058547|FD-Score:-4.77|P-value:5.27E-8 ID:SGTC_2936|Compound:9038235|FD-Score:-3.08|P-value:2.83E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.50|P-value:2.54E-7 ID:SGTC_2969|Compound:9091408|FD-Score:3.09|P-value:3.52E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-2.94|P-value:4.99E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.05|P-value:4.15E-4 ID:SGTC_2986|Compound:9022445|FD-Score:2.92|P-value:6.87E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.23|P-value:2.01E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-7.55|P-value:2.27E-17 ID:SGTC_3269|Compound:9137823|FD-Score:2.96|P-value:5.94E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-2.89|P-value:6.13E-4 ID:SGTC_3349|Compound:9149703|FD-Score:2.95|P-value:6.09E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-4.61|P-value:1.37E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:3.84|P-value:1.25E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:2.82|P-value:9.97E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-5.24|P-value:2.64E-9 ID:SGTC_549|Compound:1661-1316|FD-Score:2.91|P-value:7.29E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:6.53|P-value:3.03E-13 ID:SGTC_599|Compound:1935-0052|FD-Score:2.97|P-value:5.71E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.03|P-value:4.51E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:4.01|P-value:5.30E-6 ID:SGTC_678|Compound:1218-2179|FD-Score:-2.77|P-value:9.42E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.13|P-value:2.30E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.02|P-value:3.66E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:2.85|P-value:8.97E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:2.91|P-value:7.28E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:-3.11|P-value:2.51E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:-4.46|P-value:3.34E-7 ID:SGTC_1264|Compound:0783-0040|FD-Score:2.88|P-value:7.92E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:-3.04|P-value:3.28E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.07|P-value:3.90E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:-2.82|P-value:8.01E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.17|P-value:2.53E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.70|P-value:2.39E-5 ID:SGTC_1934|Compound:st074720|FD-Score:4.23|P-value:1.69E-6 ID:SGTC_1943|Compound:st076331|FD-Score:-2.77|P-value:9.60E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-2.79|P-value:8.96E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.84|P-value:9.05E-6 ID:SGTC_2261|Compound:9010538|FD-Score:-2.87|P-value:6.58E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-2.86|P-value:6.69E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.09|P-value:3.54E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.08|P-value:2.89E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.09|P-value:3.61E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-2.85|P-value:7.19E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.11|P-value:3.23E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.23|P-value:1.98E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.84|P-value:8.99E-6 ID:SGTC_2811|Compound:7967822|FD-Score:-2.92|P-value:5.29E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-2.77|P-value:9.56E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-4.26|P-value:1.00E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-2.80|P-value:8.49E-4 ID:SGTC_2875|Compound:9039966|FD-Score:-4.07|P-value:2.72E-6 ID:SGTC_2888|Compound:9058547|FD-Score:-4.77|P-value:5.27E-8 ID:SGTC_2936|Compound:9038235|FD-Score:-3.08|P-value:2.83E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-4.50|P-value:2.54E-7 ID:SGTC_2969|Compound:9091408|FD-Score:3.09|P-value:3.52E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-2.94|P-value:4.99E-4 ID:SGTC_2980|Compound:9014342|FD-Score:3.05|P-value:4.15E-4 ID:SGTC_2986|Compound:9022445|FD-Score:2.92|P-value:6.87E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.23|P-value:2.01E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-7.55|P-value:2.27E-17 ID:SGTC_3269|Compound:9137823|FD-Score:2.96|P-value:5.94E-4 ID:SGTC_3279|Compound:9140807|FD-Score:-2.89|P-value:6.13E-4 ID:SGTC_3349|Compound:9149703|FD-Score:2.95|P-value:6.09E-4

Top fitness defect scores for YCR013C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_563 tetrahydrosecaminediol 6.53 614.0 µM 3.03E-13 amide catabolism 1 3.21E-11 1.44
2 SGTC_1934 st074720 4.23 32.6 µM 1.69E-6 9 1.18E-5 0.14
3 SGTC_662 k832-1615 4.01 104.0 µM 5.30E-6 4 3.04E-5 0.19
4 SGTC_153 4077-0274 3.84 519.7 µM 1.25E-5 8 6.17E-5 0.06
5 SGTC_1927 st060202 3.70 13.8 µM 2.39E-5 9 1.06E-4 0.24
6 SGTC_2789 5281112 3.23 71.4 µM 1.98E-4 15 6.14E-4 0.13
7 SGTC_3012 9080433 3.23 71.4 µM 2.01E-4 12 6.22E-4 0.01
8 SGTC_1787 fluconazole 3.17 80.0 µM 2.53E-4 iron homeostasis 20 7.55E-4 0.02
9 SGTC_2760 etidronate 3.11 98.0 µM 3.23E-4 16 9.26E-4 0.04
10 SGTC_2969 9091408 3.09 28.7 µM 3.52E-4 18 9.95E-4 0.04
11 SGTC_2418 pentamidine 3.09 31.7 µM 3.54E-4 mitochondrial processes 25 9.99E-4 0.03
12 SGTC_2628 lathosterol 3.09 100.0 µM 3.61E-4 11 0.00101 0.04
13 SGTC_1424 4048-1941 3.07 275.0 µM 3.90E-4 12 0.00108 0.04
14 SGTC_2980 9014342 3.05 25.3 µM 4.15E-4 32 0.00114 0.11
15 SGTC_641 4092-0595 3.03 30.0 µM 4.51E-4 22 0.00122 0.09
16 SGTC_599 1935-0052 2.97 86.5 µM 5.71E-4 11 0.00149 0.06
17 SGTC_3269 9137823 2.96 49.5 µM 5.94E-4 60S ribosome export 9 0.00154 0.08
18 SGTC_3349 9149703 2.95 23.0 µM 6.09E-4 5 0.00157 0.16
19 SGTC_2986 9022445 2.92 71.4 µM 6.87E-4 16 0.00174 0.08
20 SGTC_1070 indatraline 2.91 8.8 µM 7.28E-4 60S ribosome export 19 0.00182 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.185 2.81E-27 YBR193C MED8 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.179 1.20E-25 YBL020W RFT1 het Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
0.159 1.94E-20 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.159 2.39E-20 YMR270C RRN9 het Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
0.144 5.15E-17 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.143 7.64E-17 YOR335C ALA1 het Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
0.133 9.69E-15 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.132 2.08E-14 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.127 1.85E-13 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.126 2.04E-13 YDR324C UTP4 het Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
0.122 1.14E-12 YHR197W RIX1 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene
0.122 1.53E-12 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.119 5.32E-12 YGL142C GPI10 het Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog
0.118 8.39E-12 YMR288W HSH155 het U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155
0.116 1.48E-11 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats