HIPHOP chemogenomics database
YCR015C_p 
Putative protein of unknown function; YCR015C is not an essential gene
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YCR015C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.230 | 1.19E-41 | YHL045W_d | YHL045W_d | hom | Putative protein of unknown function; not an essential gene |
| 0.217 | 6.90E-37 | YML029W | USA1 | hom | Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p |
| 0.206 | 1.38E-33 | YPL246C | RBD2 | hom | Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p |
| 0.190 | 1.48E-28 | YDL155W | CLB3 | hom | B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress |
| 0.186 | 1.37E-27 | YGL090W | LIF1 | hom | Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein |
| 0.186 | 1.59E-27 | YIL009W | FAA3 | hom | Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
| 0.179 | 1.34E-25 | YOR271C_p | FSF1_p | hom | Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis |
| 0.171 | 1.66E-23 | YLR034C | SMF3 | hom | Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress |
| 0.158 | 4.08E-20 | YHR134W | WSS1 | hom | Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response |
| 0.155 | 1.94E-19 | YLR040C_p | YLR040C_p | hom | Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential |
| 0.151 | 1.55E-18 | YLR317W_d | YLR317W_d | het | Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C |
| 0.148 | 7.42E-18 | YNL123W | NMA111 | hom | Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases |
| 0.144 | 3.97E-17 | YPL113C_p | YPL113C_p | hom | Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene |
| 0.139 | 6.17E-16 | YLR013W | GAT3 | hom | Protein containing GATA family zinc finger motifs |
| 0.135 | 3.91E-15 | YML025C | YML6 | het | Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins |