YCR016W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR016W / YCR016W

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.39|P-value:8.39E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.63|P-value:4.63E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-5.92|P-value:7.46E-11 ID:SGTC_71|Compound:0417-1750|FD-Score:-6.06|P-value:2.74E-11 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.28|P-value:2.10E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.03|P-value:3.84E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.13|P-value:3.85E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.48|P-value:5.82E-5 ID:SGTC_394|Compound:menadione|FD-Score:3.06|P-value:3.31E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.42|P-value:7.38E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:2.92|P-value:5.75E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.15|P-value:2.32E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.08|P-value:4.70E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.26|P-value:2.30E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.70|P-value:2.09E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:2.82|P-value:8.56E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:2.80|P-value:9.05E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:2.81|P-value:8.77E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.26|P-value:2.28E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-6.05|P-value:2.82E-11 ID:SGTC_966|Compound:1300-0360|FD-Score:3.02|P-value:3.93E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-2.90|P-value:9.27E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.79|P-value:1.35E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:-3.47|P-value:9.45E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:2.84|P-value:7.97E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:-2.95|P-value:7.82E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.45|P-value:4.36E-7 ID:SGTC_1682|Compound:st012968|FD-Score:-2.89|P-value:9.89E-4 ID:SGTC_1767|Compound:st044992|FD-Score:-3.10|P-value:4.40E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.91|P-value:7.40E-6 ID:SGTC_1870|Compound:st057514|FD-Score:-3.62|P-value:4.85E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.14|P-value:2.47E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.09|P-value:4.51E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.30|P-value:1.23E-4 ID:SGTC_2014|Compound:4013930|FD-Score:5.04|P-value:1.29E-8 ID:SGTC_2064|Compound:5220758|FD-Score:4.65|P-value:1.39E-7 ID:SGTC_2067|Compound:5224629|FD-Score:2.93|P-value:5.55E-4 ID:SGTC_2103|Compound:5378138|FD-Score:4.22|P-value:1.53E-6 ID:SGTC_2179|Compound:6298986|FD-Score:3.19|P-value:1.95E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.11|P-value:2.72E-4 ID:SGTC_2336|Compound:9001819|FD-Score:6.56|P-value:2.49E-13 ID:SGTC_2360|Compound:9040895|FD-Score:-3.41|P-value:1.24E-4 ID:SGTC_2361|Compound:9034121|FD-Score:-2.91|P-value:8.93E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-4.52|P-value:5.21E-7 ID:SGTC_2369|Compound:9071472|FD-Score:-3.08|P-value:4.72E-4 ID:SGTC_2374|Compound:9071832|FD-Score:-3.36|P-value:1.55E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-3.17|P-value:3.36E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.12|P-value:2.66E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.96|P-value:5.77E-6 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.32|P-value:1.16E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:2.95|P-value:5.28E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.94|P-value:5.46E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.48|P-value:9.04E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.98|P-value:5.34E-6 ID:SGTC_2699|Compound:st077704|FD-Score:3.28|P-value:1.38E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.32|P-value:1.17E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.73|P-value:1.84E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.42|P-value:1.19E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-2.92|P-value:8.59E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-2.88|P-value:9.99E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.39|P-value:8.39E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.63|P-value:4.63E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-5.92|P-value:7.46E-11 ID:SGTC_71|Compound:0417-1750|FD-Score:-6.06|P-value:2.74E-11 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.28|P-value:2.10E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.03|P-value:3.84E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.13|P-value:3.85E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.48|P-value:5.82E-5 ID:SGTC_394|Compound:menadione|FD-Score:3.06|P-value:3.31E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.42|P-value:7.38E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:2.92|P-value:5.75E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.15|P-value:2.32E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.08|P-value:4.70E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.26|P-value:2.30E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.70|P-value:2.09E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:2.82|P-value:8.56E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:2.80|P-value:9.05E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:2.81|P-value:8.77E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.26|P-value:2.28E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-6.05|P-value:2.82E-11 ID:SGTC_966|Compound:1300-0360|FD-Score:3.02|P-value:3.93E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-2.90|P-value:9.27E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.79|P-value:1.35E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:-3.47|P-value:9.45E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:2.84|P-value:7.97E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:-2.95|P-value:7.82E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.45|P-value:4.36E-7 ID:SGTC_1682|Compound:st012968|FD-Score:-2.89|P-value:9.89E-4 ID:SGTC_1767|Compound:st044992|FD-Score:-3.10|P-value:4.40E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.91|P-value:7.40E-6 ID:SGTC_1870|Compound:st057514|FD-Score:-3.62|P-value:4.85E-5 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.14|P-value:2.47E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.09|P-value:4.51E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.30|P-value:1.23E-4 ID:SGTC_2014|Compound:4013930|FD-Score:5.04|P-value:1.29E-8 ID:SGTC_2064|Compound:5220758|FD-Score:4.65|P-value:1.39E-7 ID:SGTC_2067|Compound:5224629|FD-Score:2.93|P-value:5.55E-4 ID:SGTC_2103|Compound:5378138|FD-Score:4.22|P-value:1.53E-6 ID:SGTC_2179|Compound:6298986|FD-Score:3.19|P-value:1.95E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.11|P-value:2.72E-4 ID:SGTC_2336|Compound:9001819|FD-Score:6.56|P-value:2.49E-13 ID:SGTC_2360|Compound:9040895|FD-Score:-3.41|P-value:1.24E-4 ID:SGTC_2361|Compound:9034121|FD-Score:-2.91|P-value:8.93E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-4.52|P-value:5.21E-7 ID:SGTC_2369|Compound:9071472|FD-Score:-3.08|P-value:4.72E-4 ID:SGTC_2374|Compound:9071832|FD-Score:-3.36|P-value:1.55E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-3.17|P-value:3.36E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.12|P-value:2.66E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.96|P-value:5.77E-6 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.32|P-value:1.16E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:2.95|P-value:5.28E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.94|P-value:5.46E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.48|P-value:9.04E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.98|P-value:5.34E-6 ID:SGTC_2699|Compound:st077704|FD-Score:3.28|P-value:1.38E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.32|P-value:1.17E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.73|P-value:1.84E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.42|P-value:1.19E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-2.92|P-value:8.59E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-2.88|P-value:9.99E-4

Top fitness defect scores for YCR016W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2336 9001819 6.56 198.7 µM 2.49E-13 heme biosynthesis & mitochondrial translocase 3 2.64E-11
2 SGTC_2014 4013930 5.04 200.0 µM 1.29E-8 9 2.28E-7
3 SGTC_2064 5220758 4.65 200.0 µM 1.39E-7 15 1.65E-6
4 SGTC_1576 erythromycin ethylsuccinate 4.45 23.2 µM 4.36E-7 16 4.29E-6
5 SGTC_2103 5378138 4.22 10.0 µM 1.53E-6 10 1.22E-5
6 SGTC_2639 lactacystin 3.98 53.0 µM 5.34E-6 21 3.48E-5
7 SGTC_2570 licareol 3.96 100.0 µM 5.77E-6 30 3.71E-5
8 SGTC_1792 st045773 3.91 43.6 µM 7.40E-6 26 4.56E-5
9 SGTC_1141 3253-0389 3.79 52.6 µM 1.35E-5 10 7.55E-5
10 SGTC_2848 9016370 3.73 26.0 µM 1.84E-5 31 9.74E-5
11 SGTC_859 0439-0102 3.70 54.6 µM 2.09E-5 redox potentiating 18 1.09E-4
12 SGTC_310 1273-0058 3.48 1.1 µM 5.82E-5 mitochondrial stress 293 2.55E-4
13 SGTC_548 1436-0017 3.42 110.0 µM 7.38E-5 TSC3-RPN4 57 3.11E-4
14 SGTC_40 0327-0103 3.39 19.8 µM 8.39E-5 47 3.47E-4
15 SGTC_2571 chrysanthemic acid 3.32 100.0 µM 1.16E-4 44 4.53E-4
16 SGTC_2700 st077718 3.32 96.8 µM 1.17E-4 26 4.57E-4
17 SGTC_1938 st074717 3.30 56.4 µM 1.23E-4 26 4.78E-4
18 SGTC_2699 st077704 3.28 54.6 µM 1.38E-4 endomembrane recycling 79 5.26E-4
19 SGTC_2179 6298986 3.19 200.0 µM 1.95E-4 heme requiring 37 7.01E-4
20 SGTC_735 3076-0345 3.15 636.0 µM 2.32E-4 73 8.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 7.57E-9 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.099 7.69E-9 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.094 4.84E-8 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.091 1.21E-7 YFL003C MSH4 hom Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
0.089 2.65E-7 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.088 3.45E-7 YPL006W NCR1 hom Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
0.085 8.79E-7 YLR326W_p YLR326W_p hom Putative protein of unknown function, predicted to be palmitoylated
0.084 1.08E-6 YIL103W DPH1 hom Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p
0.082 2.07E-6 YHR203C RPS4B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
0.080 4.00E-6 YJR004C SAG1 hom Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
0.078 6.75E-6 YGR140W CBF2 het Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; relative distribution to the spindle pole body decreases upon DNA replication stress
0.077 7.82E-6 YPL143W RPL33A het Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication
0.075 1.23E-5 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.075 1.30E-5 YAL065C_p YAL065C_p hom Putative protein of unknown function; has homology to FLO1; possible pseudogene
0.074 1.75E-5 YOR317W FAA1 hom Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms ER foci upon DNA replication stress; FAA1 has a paralog, FAA4, that arose from the whole genome duplication