HIPHOP chemogenomics database

YCR024C / SLM5

Mitochondrial asparaginyl-tRNA synthetase

Zygosity: Homozygous strain

fixedexpanded
Profile for YCR024C / SLM5

Click on Significant Values for Screen Details

Top fitness defect scores for YCR024C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	23.30	5.3 µM	2.23E-94		38	9.52E-121
2	SGTC_70	0141-0289	16.40	43.3 µM	8.91E-48	mitochondrial stress	7	8.26E-61
3	SGTC_1635	st007035	15.30	42.4 µM	7.70E-42		37	3.53E-53
4	SGTC_275	trichlorophene	13.00	5.7 µM	9.20E-31	mitochondrial stress	16	6.04E-39
5	SGTC_119	0121-0043	12.70	24.8 µM	1.33E-29	mitochondrial stress	4	1.86E-37
6	SGTC_908	3448-7491	10.70	47.7 µM	1.83E-21	mitochondrial stress	6	5.23E-27
7	SGTC_134	0269-0018	9.80	6.9 µM	2.61E-18		40	5.81E-23
8	SGTC_386	1509-0011	9.47	3.1 µM	3.01E-17		50	1.34E-21
9	SGTC_116	0155-0182	8.53	31.8 µM	2.48E-14	mitochondrial response to ROS	8	7.26E-18
10	SGTC_310	1273-0058	8.28	1.1 µM	1.33E-13	mitochondrial stress	80	6.25E-17
11	SGTC_173	1273-0061	8.02	2.7 µM	6.96E-13	mitochondrial stress	65	5.20E-16
12	SGTC_1371	2421-0008	7.60	32.7 µM	9.67E-12	mitochondrial processes	2	1.51E-14
13	SGTC_2183	6420625	7.53	130.5 µM	1.48E-11	mitochondrial processes	8	2.60E-14
14	SGTC_1882	5615643	7.09	20.0 µM	1.89E-10	TRP & mitochondrial translation	12	6.77E-13
15	SGTC_1188	1403-0014	6.58	4.6 µM	3.08E-9	mitochondrial stress	14	2.39E-11
16	SGTC_314	1671-0008	6.36	2.7 µM	9.49E-9		5	1.00E-10
17	SGTC_19	0279-0214	5.99	38.4 µM	5.87E-8	TRP & mitochondrial translation	11	1.03E-9
18	SGTC_782	0083-0095	5.91	30.5 µM	8.96E-8		4	1.76E-9
19	SGTC_2688	kanamycin b	5.72	96.7 µM	2.13E-7	calcium & mitochondrial duress	176	5.33E-9
20	SGTC_124	0136-0217	5.59	7.1 µM	3.80E-7	mitochondrial stress	26	1.11E-8

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.637	0	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.581	5.33E-302	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.569	8.37E-287	YNL213C	RRG9	hom	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.566	6.34E-284	YPR166C	MRP2	hom	Mitochondrial ribosomal protein of the small subunit
0.563	6.48E-280	YDR079W	PET100	hom	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.556	2.20E-271	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.546	5.60E-260	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.542	6.14E-256	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.540	1.90E-253	YDR533C	HSP31	hom	Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.533	2.96E-245	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.532	1.08E-244	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.519	2.06E-230	YOR158W	PET123	hom	Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.516	3.02E-228	YKL068W-A_p	YKL068W-A_p	hom	Putative protein of unknown function; identified by homology to Ashbya gossypii
0.502	1.54E-213	YGL064C	MRH4	hom	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.496	1.04E-207	YKL194C	MST1	hom	Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro