YCR046C / IMG1

Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR046C / IMG1

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.15|P-value:4.71E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:4.42|P-value:1.62E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:3.62|P-value:3.21E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:5.53|P-value:1.02E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:11.70|P-value:2.57E-28 ID:SGTC_72|Compound:0744-0168|FD-Score:3.37|P-value:7.30E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.18|P-value:4.21E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.01|P-value:1.27E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:7.11|P-value:1.35E-11 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.61|P-value:3.30E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.04|P-value:2.40E-14 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.90|P-value:2.06E-6 ID:SGTC_283|Compound:0987-0079|FD-Score:3.45|P-value:5.78E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.84|P-value:9.85E-14 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.57|P-value:4.86E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.94|P-value:2.46E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.17|P-value:8.39E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.00|P-value:1.11E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.79|P-value:2.36E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.59|P-value:3.56E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.47|P-value:5.33E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:4.45|P-value:1.40E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.75|P-value:2.02E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.96|P-value:9.46E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.56|P-value:8.90E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.69|P-value:2.50E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:5.07|P-value:9.32E-7 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.62|P-value:3.25E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.39|P-value:6.93E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.03|P-value:7.41E-9 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.87|P-value:3.33E-6 ID:SGTC_1912|Compound:st060209|FD-Score:4.23|P-value:3.39E-5 ID:SGTC_1956|Compound:st077085|FD-Score:-3.66|P-value:3.59E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.65|P-value:2.91E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.99|P-value:8.61E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.91|P-value:1.15E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.47|P-value:5.34E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.54|P-value:9.80E-6 ID:SGTC_2431|Compound:5490079|FD-Score:-3.55|P-value:5.30E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-3.38|P-value:9.15E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-4.85|P-value:3.57E-6 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-4.35|P-value:2.89E-5 ID:SGTC_2526|Compound:patulin|FD-Score:3.56|P-value:3.91E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.07|P-value:6.37E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.40|P-value:8.52E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.81|P-value:3.09E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.81|P-value:1.65E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.85|P-value:3.57E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.24|P-value:4.52E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.60|P-value:3.41E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.04|P-value:7.16E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.05|P-value:1.93E-11 ID:SGTC_2695|Compound:st077686|FD-Score:-4.68|P-value:7.42E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:-8.93|P-value:5.59E-17 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.94|P-value:2.39E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.38|P-value:2.60E-5 ID:SGTC_2817|Compound:7995342|FD-Score:-3.84|P-value:1.96E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-3.98|P-value:1.20E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.63|P-value:4.10E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-5.99|P-value:1.45E-8 ID:SGTC_2956|Compound:9076196|FD-Score:-4.58|P-value:1.15E-5 ID:SGTC_2957|Compound:9076800|FD-Score:4.97|P-value:1.52E-6 ID:SGTC_2962|Compound:9082311|FD-Score:-4.00|P-value:1.11E-4 ID:SGTC_2965|Compound:9082772|FD-Score:6.89|P-value:5.21E-11 ID:SGTC_2966|Compound:9084041|FD-Score:-3.71|P-value:3.03E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.90|P-value:1.21E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.29|P-value:9.57E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.29|P-value:9.65E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.15|P-value:4.71E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:4.42|P-value:1.62E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:3.62|P-value:3.21E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:5.53|P-value:1.02E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:11.70|P-value:2.57E-28 ID:SGTC_72|Compound:0744-0168|FD-Score:3.37|P-value:7.30E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.18|P-value:4.21E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.01|P-value:1.27E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:7.11|P-value:1.35E-11 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.61|P-value:3.30E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.04|P-value:2.40E-14 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.90|P-value:2.06E-6 ID:SGTC_283|Compound:0987-0079|FD-Score:3.45|P-value:5.78E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.84|P-value:9.85E-14 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.57|P-value:4.86E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.94|P-value:2.46E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.17|P-value:8.39E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.00|P-value:1.11E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.79|P-value:2.36E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.59|P-value:3.56E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.47|P-value:5.33E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:4.45|P-value:1.40E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.75|P-value:2.02E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.96|P-value:9.46E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.56|P-value:8.90E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:3.69|P-value:2.50E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:5.07|P-value:9.32E-7 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.62|P-value:3.25E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.39|P-value:6.93E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.03|P-value:7.41E-9 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.87|P-value:3.33E-6 ID:SGTC_1912|Compound:st060209|FD-Score:4.23|P-value:3.39E-5 ID:SGTC_1956|Compound:st077085|FD-Score:-3.66|P-value:3.59E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.65|P-value:2.91E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.99|P-value:8.61E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.91|P-value:1.15E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.47|P-value:5.34E-4 ID:SGTC_2430|Compound:5571206|FD-Score:4.54|P-value:9.80E-6 ID:SGTC_2431|Compound:5490079|FD-Score:-3.55|P-value:5.30E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-3.38|P-value:9.15E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:-4.85|P-value:3.57E-6 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-4.35|P-value:2.89E-5 ID:SGTC_2526|Compound:patulin|FD-Score:3.56|P-value:3.91E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.07|P-value:6.37E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.40|P-value:8.52E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.81|P-value:3.09E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.81|P-value:1.65E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.85|P-value:3.57E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.24|P-value:4.52E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.60|P-value:3.41E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.04|P-value:7.16E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.05|P-value:1.93E-11 ID:SGTC_2695|Compound:st077686|FD-Score:-4.68|P-value:7.42E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:-8.93|P-value:5.59E-17 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.94|P-value:2.39E-6 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.38|P-value:2.60E-5 ID:SGTC_2817|Compound:7995342|FD-Score:-3.84|P-value:1.96E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-3.98|P-value:1.20E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.63|P-value:4.10E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-5.99|P-value:1.45E-8 ID:SGTC_2956|Compound:9076196|FD-Score:-4.58|P-value:1.15E-5 ID:SGTC_2957|Compound:9076800|FD-Score:4.97|P-value:1.52E-6 ID:SGTC_2962|Compound:9082311|FD-Score:-4.00|P-value:1.11E-4 ID:SGTC_2965|Compound:9082772|FD-Score:6.89|P-value:5.21E-11 ID:SGTC_2966|Compound:9084041|FD-Score:-3.71|P-value:3.03E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.90|P-value:1.21E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.29|P-value:9.57E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.29|P-value:9.65E-4

Top fitness defect scores for YCR046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_70 0141-0289 11.70 43.3 µM 2.57E-28 mitochondrial stress 16 4.60E-32
2 SGTC_236 1509-0011 8.04 5.3 µM 2.40E-14 250 4.35E-16
3 SGTC_310 1273-0058 7.84 1.1 µM 9.85E-14 mitochondrial stress 95 2.19E-15
4 SGTC_173 1273-0061 7.11 2.7 µM 1.35E-11 mitochondrial stress 84 5.99E-13
5 SGTC_2688 kanamycin b 7.05 96.7 µM 1.93E-11 calcium & mitochondrial duress 106 9.00E-13
6 SGTC_2965 9082772 6.89 38.6 µM 5.21E-11 mitochondrial response to ROS 7 2.80E-12
7 SGTC_1742 st038235 6.03 28.9 µM 7.41E-9 mitochondrial stress 44 7.96E-10
8 SGTC_68 0986-0284 5.53 82.8 µM 1.02E-7 23 1.58E-8
9 SGTC_1542 7-hydroxy-3'-methoxyflavone 5.07 49.7 µM 9.32E-7 4 1.95E-7
10 SGTC_119 0121-0043 5.01 24.8 µM 1.27E-6 mitochondrial stress 54 2.76E-7
11 SGTC_2957 9076800 4.97 11.5 µM 1.52E-6 9 3.39E-7
12 SGTC_275 trichlorophene 4.90 5.7 µM 2.06E-6 mitochondrial stress 173 4.79E-7
13 SGTC_2570 licareol 4.81 100.0 µM 3.09E-6 14 7.59E-7
14 SGTC_1456 k015-0012 4.56 13.0 µM 8.90E-6 20 2.52E-6
15 SGTC_2430 5571206 4.54 200.0 µM 9.80E-6 40 2.81E-6
16 SGTC_941 3237-0776 4.45 460.0 µM 1.40E-5 5 4.21E-6
17 SGTC_63 0099-0242 4.42 26.7 µM 1.62E-5 mitochondrial stress 74 4.97E-6
18 SGTC_1912 st060209 4.23 90.8 µM 3.39E-5 33 1.15E-5
19 SGTC_118 0083-0097 4.18 135.3 µM 4.21E-5 translation 112 1.47E-5
20 SGTC_28 pentachloropyridine N-oxide 4.15 1.6 µM 4.71E-5 TSC3-RPN4 63 1.67E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.457 1.89E-172 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.453 3.94E-169 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.411 1.40E-136 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.408 1.17E-134 YNL073W MSK1 hom Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)
0.401 9.95E-130 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.392 2.02E-123 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.392 1.28E-122 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.391 4.07E-123 YMR064W AEP1 hom Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase
0.382 1.01E-116 YIL014C-A_p YIL014C-A_p hom Putative protein of unknown function
0.378 5.78E-114 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.375 2.77E-112 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.373 6.29E-111 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.372 1.34E-110 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.372 1.34E-110 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.365 2.43E-106 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss