YCR054C / CTR86

Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YCR054C / CTR86

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:-2.88|P-value:5.52E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-2.87|P-value:5.82E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.65|P-value:1.70E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.11|P-value:1.82E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.05|P-value:2.33E-4 ID:SGTC_230|Compound:MPP+|FD-Score:5.64|P-value:5.54E-11 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:2.73|P-value:8.61E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:2.77|P-value:7.50E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.73|P-value:9.67E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.77|P-value:9.61E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:3.08|P-value:2.08E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.51|P-value:2.96E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-7.93|P-value:9.19E-20 ID:SGTC_789|Compound:1309-1135|FD-Score:-2.95|P-value:4.23E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:2.86|P-value:5.26E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.87|P-value:4.67E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.06|P-value:2.28E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.87|P-value:5.63E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.96|P-value:3.43E-6 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.11|P-value:1.82E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:-4.18|P-value:1.07E-6 ID:SGTC_1473|Compound:k844-0725|FD-Score:2.77|P-value:7.41E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:2.96|P-value:3.48E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.80|P-value:6.94E-6 ID:SGTC_1714|Compound:st033236|FD-Score:3.75|P-value:8.63E-6 ID:SGTC_1759|Compound:st043059|FD-Score:-4.01|P-value:2.64E-6 ID:SGTC_1761|Compound:st044296|FD-Score:-3.47|P-value:4.08E-5 ID:SGTC_1855|Compound:st056195|FD-Score:2.95|P-value:3.54E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-2.78|P-value:8.06E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.41|P-value:5.54E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.51|P-value:1.26E-7 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.36|P-value:5.93E-5 ID:SGTC_2253|Compound:7938677|FD-Score:-2.94|P-value:4.26E-4 ID:SGTC_2299|Compound:7976368|FD-Score:2.94|P-value:3.82E-4 ID:SGTC_2336|Compound:9001819|FD-Score:2.84|P-value:5.73E-4 ID:SGTC_2483|Compound:5729050|FD-Score:2.71|P-value:9.49E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.58|P-value:2.08E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-2.96|P-value:3.98E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.25|P-value:9.72E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.84|P-value:6.45E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.05|P-value:2.35E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.31|P-value:8.79E-5 ID:SGTC_2602|Compound:kawain|FD-Score:4.89|P-value:1.12E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:2.82|P-value:6.24E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-3.88|P-value:5.33E-6 ID:SGTC_2699|Compound:st077704|FD-Score:2.70|P-value:9.80E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.36|P-value:5.97E-5 ID:SGTC_3291|Compound:9121177|FD-Score:2.99|P-value:3.07E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:-2.88|P-value:5.52E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-2.87|P-value:5.82E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.65|P-value:1.70E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.11|P-value:1.82E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.05|P-value:2.33E-4 ID:SGTC_230|Compound:MPP+|FD-Score:5.64|P-value:5.54E-11 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:2.73|P-value:8.61E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:2.77|P-value:7.50E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.73|P-value:9.67E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.77|P-value:9.61E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:3.08|P-value:2.08E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.51|P-value:2.96E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-7.93|P-value:9.19E-20 ID:SGTC_789|Compound:1309-1135|FD-Score:-2.95|P-value:4.23E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:2.86|P-value:5.26E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.87|P-value:4.67E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.06|P-value:2.28E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.87|P-value:5.63E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.96|P-value:3.43E-6 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.11|P-value:1.82E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:-4.18|P-value:1.07E-6 ID:SGTC_1473|Compound:k844-0725|FD-Score:2.77|P-value:7.41E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:2.96|P-value:3.48E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.80|P-value:6.94E-6 ID:SGTC_1714|Compound:st033236|FD-Score:3.75|P-value:8.63E-6 ID:SGTC_1759|Compound:st043059|FD-Score:-4.01|P-value:2.64E-6 ID:SGTC_1761|Compound:st044296|FD-Score:-3.47|P-value:4.08E-5 ID:SGTC_1855|Compound:st056195|FD-Score:2.95|P-value:3.54E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-2.78|P-value:8.06E-4 ID:SGTC_2159|Compound:5658611|FD-Score:-3.41|P-value:5.54E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.51|P-value:1.26E-7 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.36|P-value:5.93E-5 ID:SGTC_2253|Compound:7938677|FD-Score:-2.94|P-value:4.26E-4 ID:SGTC_2299|Compound:7976368|FD-Score:2.94|P-value:3.82E-4 ID:SGTC_2336|Compound:9001819|FD-Score:2.84|P-value:5.73E-4 ID:SGTC_2483|Compound:5729050|FD-Score:2.71|P-value:9.49E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.58|P-value:2.08E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-2.96|P-value:3.98E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.25|P-value:9.72E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.84|P-value:6.45E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.05|P-value:2.35E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.31|P-value:8.79E-5 ID:SGTC_2602|Compound:kawain|FD-Score:4.89|P-value:1.12E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:2.82|P-value:6.24E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-3.88|P-value:5.33E-6 ID:SGTC_2699|Compound:st077704|FD-Score:2.70|P-value:9.80E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.36|P-value:5.97E-5 ID:SGTC_3291|Compound:9121177|FD-Score:2.99|P-value:3.07E-4

Top fitness defect scores for YCR054C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_230 MPP+ 5.64 141.7 µM 5.54E-11 1 8.27E-9 0.78
2 SGTC_2602 kawain 4.89 100.0 µM 1.12E-8 3 5.03E-7 0.36
3 SGTC_2247 cerulenin 4.51 830.0 nM 1.26E-7 2 3.28E-6 0.16
4 SGTC_1034 k072-0165 3.87 12.7 µM 4.67E-6 Golgi 6 5.38E-5 0.34
5 SGTC_1626 st003712 3.80 1.8 µM 6.94E-6 10 7.32E-5 0.10
6 SGTC_1714 st033236 3.75 13.6 µM 8.63E-6 9 8.67E-5 0.11
7 SGTC_367 0335-0881 3.73 7.1 µM 9.67E-6 ubiquinone biosynthesis & proteasome 26 9.48E-5 0.02
8 SGTC_2566 crystal violet carbinol 3.58 226.0 nM 2.08E-5 25 1.72E-4 0.05
9 SGTC_716 1683-5115 3.51 658.0 µM 2.96E-5 6 2.26E-4 0.17
10 SGTC_2252 omeprazole 3.36 400.0 µM 5.93E-5 1 3.88E-4 0.36
11 SGTC_3012 9080433 3.36 71.4 µM 5.97E-5 8 3.90E-4 0.08
12 SGTC_2576 guaiol 3.25 23.1 µM 9.72E-5 19 5.70E-4 0.01
13 SGTC_103 0844-0104 3.11 51.8 µM 1.82E-4 ERAD & cell cycle 67 9.28E-4 0.06
14 SGTC_1324 1418-0026 3.11 34.4 µM 1.82E-4 8 9.30E-4 0.03
15 SGTC_697 0508-1955 3.08 564.0 µM 2.08E-4 5 0.00103 0.11
16 SGTC_1043 0916-0009 3.06 19.3 µM 2.28E-4 15 0.00111 0.09
17 SGTC_169 k015-0017 3.05 16.0 µM 2.33E-4 9 0.00113 0.02
18 SGTC_2595 hexamethylquercetagetin 3.05 100.0 µM 2.35E-4 20 0.00114 0.01
19 SGTC_3291 9121177 2.99 71.4 µM 3.07E-4 7 0.00140 0.16
20 SGTC_1503 4585-0012 2.96 61.3 µM 3.48E-4 19 0.00154 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.72E-18 YMR270C RRN9 het Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
0.139 4.94E-16 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.139 6.64E-16 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.133 1.04E-14 YER136W GDI1 het GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
0.127 1.89E-13 YLL035W GRC3 het Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
0.120 2.47E-12 YKL153W_d YKL153W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
0.115 2.29E-11 YNR038W DBP6 het Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
0.114 3.79E-11 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.113 5.58E-11 YNL132W KRE33 het Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.113 6.34E-11 YGL097W SRM1 het Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
0.111 1.03E-10 YGL018C JAC1 het Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
0.110 1.43E-10 YPL146C NOP53 het Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
0.110 1.88E-10 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.106 6.26E-10 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.105 1.10E-9 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA