YCR064C_d

Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR064C / YCR064C

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.85|P-value:4.45E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.71|P-value:2.41E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:5.74|P-value:3.58E-7 ID:SGTC_89|Compound:0302-0250|FD-Score:5.57|P-value:7.40E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:-6.65|P-value:4.12E-9 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.73|P-value:6.09E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:10.50|P-value:7.29E-20 ID:SGTC_118|Compound:0083-0097|FD-Score:6.06|P-value:8.16E-8 ID:SGTC_126|Compound:0417-1624|FD-Score:3.99|P-value:2.82E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.79|P-value:1.74E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:4.19|P-value:1.49E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:7.74|P-value:1.11E-11 ID:SGTC_207|Compound:4185-0010|FD-Score:4.37|P-value:7.96E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.06|P-value:6.13E-6 ID:SGTC_229|Compound:benomyl|FD-Score:6.60|P-value:6.03E-9 ID:SGTC_232|Compound:clozapine|FD-Score:12.10|P-value:6.04E-26 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.59|P-value:3.64E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.33|P-value:9.20E-5 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:7.37|P-value:9.56E-11 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:10.90|P-value:1.52E-21 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.11|P-value:5.12E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:7.55|P-value:3.46E-11 ID:SGTC_301|Compound:4119-0100|FD-Score:7.11|P-value:3.92E-10 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.44|P-value:1.24E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:8.25|P-value:5.00E-13 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.76|P-value:5.76E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:4.87|P-value:1.28E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:4.98|P-value:8.53E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:5.17|P-value:3.93E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-7.01|P-value:6.37E-10 ID:SGTC_572|Compound:0960-0087|FD-Score:-5.77|P-value:2.85E-7 ID:SGTC_586|Compound:0957-0265|FD-Score:-4.37|P-value:7.74E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:3.64|P-value:8.36E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:-5.87|P-value:1.83E-7 ID:SGTC_770|Compound:0389-1121|FD-Score:5.41|P-value:1.47E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:4.12|P-value:1.85E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:5.34|P-value:1.97E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:3.90|P-value:3.77E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:25.10|P-value:5.22E-105 ID:SGTC_994|Compound:3910-0338|FD-Score:6.10|P-value:6.87E-8 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.06|P-value:2.29E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.03|P-value:2.48E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.63|P-value:8.74E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.90|P-value:3.85E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.25|P-value:2.92E-6 ID:SGTC_1326|Compound:1431-2094|FD-Score:5.92|P-value:1.54E-7 ID:SGTC_1630|Compound:st005209|FD-Score:4.43|P-value:6.50E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-3.74|P-value:6.02E-4 ID:SGTC_1712|Compound:st032288|FD-Score:7.05|P-value:5.54E-10 ID:SGTC_1739|Compound:st037196|FD-Score:3.91|P-value:3.66E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.66|P-value:2.90E-5 ID:SGTC_1781|Compound:st038725|FD-Score:9.79|P-value:1.30E-17 ID:SGTC_1786|Compound:berberine|FD-Score:-4.10|P-value:1.91E-4 ID:SGTC_1797|Compound:st048695|FD-Score:7.04|P-value:5.72E-10 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.22|P-value:3.92E-8 ID:SGTC_1930|Compound:st074634|FD-Score:-4.49|P-value:4.94E-5 ID:SGTC_1933|Compound:st074711|FD-Score:4.06|P-value:2.29E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.89|P-value:3.75E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.76|P-value:5.92E-4 ID:SGTC_1991|Compound:st073000|FD-Score:5.03|P-value:6.86E-6 ID:SGTC_2174|Compound:5790901|FD-Score:4.80|P-value:1.70E-5 ID:SGTC_2212|Compound:7123476|FD-Score:3.63|P-value:8.74E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.59|P-value:9.69E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-3.83|P-value:4.53E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.63|P-value:8.61E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.73|P-value:6.37E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.63|P-value:5.83E-7 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.34|P-value:8.51E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.85|P-value:1.37E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.14|P-value:1.78E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:5.04|P-value:6.67E-6 ID:SGTC_2790|Compound:5423970|FD-Score:4.79|P-value:1.75E-5 ID:SGTC_2794|Compound:7785382|FD-Score:-3.64|P-value:8.04E-4 ID:SGTC_2816|Compound:7982706|FD-Score:5.39|P-value:1.64E-6 ID:SGTC_2820|Compound:7989630|FD-Score:5.52|P-value:9.35E-7 ID:SGTC_2825|Compound:7998094|FD-Score:5.32|P-value:2.15E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-3.58|P-value:9.55E-4 ID:SGTC_2873|Compound:9040596|FD-Score:6.17|P-value:4.92E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-7.66|P-value:1.64E-11 ID:SGTC_2993|Compound:9054257|FD-Score:-5.38|P-value:1.56E-6 ID:SGTC_3152|Compound:9099253|FD-Score:5.48|P-value:1.12E-6 ID:SGTC_3222|Compound:9128301|FD-Score:-4.13|P-value:1.75E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-4.27|P-value:1.08E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-3.99|P-value:2.72E-4 ID:SGTC_3307|Compound:9126885|FD-Score:4.31|P-value:9.95E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:3.85|P-value:4.45E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.71|P-value:2.41E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:5.74|P-value:3.58E-7 ID:SGTC_89|Compound:0302-0250|FD-Score:5.57|P-value:7.40E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:-6.65|P-value:4.12E-9 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.73|P-value:6.09E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:10.50|P-value:7.29E-20 ID:SGTC_118|Compound:0083-0097|FD-Score:6.06|P-value:8.16E-8 ID:SGTC_126|Compound:0417-1624|FD-Score:3.99|P-value:2.82E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.79|P-value:1.74E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:4.19|P-value:1.49E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:7.74|P-value:1.11E-11 ID:SGTC_207|Compound:4185-0010|FD-Score:4.37|P-value:7.96E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.06|P-value:6.13E-6 ID:SGTC_229|Compound:benomyl|FD-Score:6.60|P-value:6.03E-9 ID:SGTC_232|Compound:clozapine|FD-Score:12.10|P-value:6.04E-26 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.59|P-value:3.64E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:4.33|P-value:9.20E-5 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:7.37|P-value:9.56E-11 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:10.90|P-value:1.52E-21 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.11|P-value:5.12E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:7.55|P-value:3.46E-11 ID:SGTC_301|Compound:4119-0100|FD-Score:7.11|P-value:3.92E-10 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.44|P-value:1.24E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:8.25|P-value:5.00E-13 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.76|P-value:5.76E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:4.87|P-value:1.28E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:4.98|P-value:8.53E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:5.17|P-value:3.93E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-7.01|P-value:6.37E-10 ID:SGTC_572|Compound:0960-0087|FD-Score:-5.77|P-value:2.85E-7 ID:SGTC_586|Compound:0957-0265|FD-Score:-4.37|P-value:7.74E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:3.64|P-value:8.36E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:-5.87|P-value:1.83E-7 ID:SGTC_770|Compound:0389-1121|FD-Score:5.41|P-value:1.47E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:4.12|P-value:1.85E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:5.34|P-value:1.97E-6 ID:SGTC_888|Compound:0916-0002|FD-Score:3.90|P-value:3.77E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:25.10|P-value:5.22E-105 ID:SGTC_994|Compound:3910-0338|FD-Score:6.10|P-value:6.87E-8 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.06|P-value:2.29E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.03|P-value:2.48E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.63|P-value:8.74E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.90|P-value:3.85E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.25|P-value:2.92E-6 ID:SGTC_1326|Compound:1431-2094|FD-Score:5.92|P-value:1.54E-7 ID:SGTC_1630|Compound:st005209|FD-Score:4.43|P-value:6.50E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-3.74|P-value:6.02E-4 ID:SGTC_1712|Compound:st032288|FD-Score:7.05|P-value:5.54E-10 ID:SGTC_1739|Compound:st037196|FD-Score:3.91|P-value:3.66E-4 ID:SGTC_1760|Compound:st045453|FD-Score:4.66|P-value:2.90E-5 ID:SGTC_1781|Compound:st038725|FD-Score:9.79|P-value:1.30E-17 ID:SGTC_1786|Compound:berberine|FD-Score:-4.10|P-value:1.91E-4 ID:SGTC_1797|Compound:st048695|FD-Score:7.04|P-value:5.72E-10 ID:SGTC_1875|Compound:nocodazole|FD-Score:6.22|P-value:3.92E-8 ID:SGTC_1930|Compound:st074634|FD-Score:-4.49|P-value:4.94E-5 ID:SGTC_1933|Compound:st074711|FD-Score:4.06|P-value:2.29E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.89|P-value:3.75E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.76|P-value:5.92E-4 ID:SGTC_1991|Compound:st073000|FD-Score:5.03|P-value:6.86E-6 ID:SGTC_2174|Compound:5790901|FD-Score:4.80|P-value:1.70E-5 ID:SGTC_2212|Compound:7123476|FD-Score:3.63|P-value:8.74E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.59|P-value:9.69E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-3.83|P-value:4.53E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.63|P-value:8.61E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.73|P-value:6.37E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.63|P-value:5.83E-7 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.34|P-value:8.51E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.85|P-value:1.37E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.14|P-value:1.78E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:5.04|P-value:6.67E-6 ID:SGTC_2790|Compound:5423970|FD-Score:4.79|P-value:1.75E-5 ID:SGTC_2794|Compound:7785382|FD-Score:-3.64|P-value:8.04E-4 ID:SGTC_2816|Compound:7982706|FD-Score:5.39|P-value:1.64E-6 ID:SGTC_2820|Compound:7989630|FD-Score:5.52|P-value:9.35E-7 ID:SGTC_2825|Compound:7998094|FD-Score:5.32|P-value:2.15E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-3.58|P-value:9.55E-4 ID:SGTC_2873|Compound:9040596|FD-Score:6.17|P-value:4.92E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-7.66|P-value:1.64E-11 ID:SGTC_2993|Compound:9054257|FD-Score:-5.38|P-value:1.56E-6 ID:SGTC_3152|Compound:9099253|FD-Score:5.48|P-value:1.12E-6 ID:SGTC_3222|Compound:9128301|FD-Score:-4.13|P-value:1.75E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-4.27|P-value:1.08E-4 ID:SGTC_3298|Compound:9116858|FD-Score:-3.99|P-value:2.72E-4 ID:SGTC_3307|Compound:9126885|FD-Score:4.31|P-value:9.95E-5

Top fitness defect scores for YCR064C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_940 3232-1287 25.10 54.8 µM 5.22E-105 NEO1 1 1.25E-139
2 SGTC_232 clozapine 12.10 119.0 µM 6.04E-26 NEO1 15 4.77E-34
3 SGTC_241 5hr heat shock (37°C) + cantharidin 10.90 155.4 µM 1.52E-21 cell wall signaling 11 3.55E-28
4 SGTC_117 lucigenin 10.50 22.1 µM 7.29E-20 redox potentiating 8 6.17E-26
5 SGTC_1781 st038725 9.79 66.3 µM 1.30E-17 NEO1 17 6.19E-23
6 SGTC_313 3474-0040 8.25 5.0 µM 5.00E-13 NEO1-PIK1 9 7.91E-17
7 SGTC_206 4546-0025 7.74 72.0 µM 1.11E-11 NEO1 23 4.93E-15
8 SGTC_243 5hr heat shock (37°C) + splitomicin 7.55 1.0 µM 3.46E-11 heat shock/prefoldin 11 2.23E-14
9 SGTC_240 5hr heat shock (37°C) + Streptovitacin 7.37 300.0 µM 9.56E-11 heat shock/prefoldin 10 8.60E-14
10 SGTC_301 4119-0100 7.11 24.5 µM 3.92E-10 NEO1 30 5.62E-13
11 SGTC_1712 st032288 7.05 53.4 µM 5.54E-10 calcium & mitochondrial duress 54 8.91E-13
12 SGTC_1797 st048695 7.04 56.8 µM 5.72E-10 NEO1 32 9.29E-13
13 SGTC_229 benomyl 6.60 22.9 µM 6.03E-9 tubulin folding & SWR complex 15 2.12E-11
14 SGTC_1875 nocodazole 6.22 6.0 µM 3.92E-8 tubulin folding & SWR complex 29 2.55E-10
15 SGTC_2873 9040596 6.17 71.4 µM 4.92E-8 12 3.45E-10
16 SGTC_994 3910-0338 6.10 138.0 µM 6.87E-8 calcium & mitochondrial duress 14 5.38E-10
17 SGTC_118 0083-0097 6.06 135.3 µM 8.16E-8 translation 22 6.76E-10
18 SGTC_1326 1431-2094 5.92 10.8 µM 1.54E-7 tubulin folding & SWR complex 13 1.58E-9
19 SGTC_84 0443-0269 5.74 128.8 µM 3.58E-7 4 4.81E-9
20 SGTC_2627 acetyl isogambogic acid 5.63 100.0 µM 5.83E-7 TSC3-RPN4 19 9.16E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.386 2.45E-119 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.372 1.24E-110 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.369 2.74E-108 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.341 6.79E-92 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
0.322 7.86E-82 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.311 3.58E-76 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.294 1.14E-67 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.293 2.73E-67 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.290 3.13E-66 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.284 2.06E-63 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
0.268 2.32E-56 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.267 1.10E-55 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.259 2.38E-52 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.252 1.44E-49 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.240 4.18E-45 YDL115C IWR1 hom RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress