HIPHOP chemogenomics database

YCR071C / IMG2

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain

fixedexpanded
Profile for YCR071C / IMG2

Click on Significant Values for Screen Details

Top fitness defect scores for YCR071C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	13.90	5.3 µM	1.86E-38		120	3.57E-44
2	SGTC_310	1273-0058	11.40	1.1 µM	1.05E-26	mitochondrial stress	26	1.42E-30
3	SGTC_2589	lobaric acid	7.67	100.0 µM	4.76E-13		3	8.59E-15
4	SGTC_2617	dihydrotanshinone i	7.28	20.8 µM	6.27E-12	copper-dependent oxidative stress	8	1.68E-13
5	SGTC_2927	9011802	7.26	47.9 µM	7.13E-12		1	1.95E-13
6	SGTC_173	1273-0061	6.58	2.7 µM	4.63E-10	mitochondrial stress	96	2.41E-11
7	SGTC_2454	5-benzylidenerhodanine	6.54	10.4 µM	5.63E-10	TRP & mitochondrial translation	9	3.02E-11
8	SGTC_63	0099-0242	6.14	26.7 µM	5.47E-9	mitochondrial stress	27	4.14E-10
9	SGTC_2688	kanamycin b	5.43	96.7 µM	2.18E-7	calcium & mitochondrial duress	201	2.89E-8
10	SGTC_2620	irigenin	5.39	100.0 µM	2.64E-7		11	3.61E-8
11	SGTC_275	trichlorophene	4.80	5.7 µM	3.90E-6	mitochondrial stress	183	7.98E-7
12	SGTC_3218	9131285	4.77	49.5 µM	4.40E-6	endomembrane recycling	21	9.18E-7
13	SGTC_2017	5132927	4.64	60.6 µM	7.58E-6		15	1.71E-6
14	SGTC_2637	3-alpha-acetoxydihydrodeoxygedunin	4.51	100.0 µM	1.30E-5		16	3.20E-6
15	SGTC_2472	5377652	4.38	49.4 µM	2.25E-5	TRP & mitochondrial translation	41	5.99E-6
16	SGTC_2250	alverine citrate	4.34	130.0 µM	2.58E-5		130	6.98E-6
17	SGTC_1750	st081859	4.29	2.4 µM	3.15E-5	endomembrane recycling	163	8.79E-6
18	SGTC_883	0850-0245	4.22	24.6 µM	4.21E-5	cell wall	27	1.23E-5
19	SGTC_831	k061-1017	4.19	217.0 µM	4.65E-5	translation	53	1.38E-5
20	SGTC_2078	5212016	4.18	200.0 µM	4.84E-5	60S ribosome export	11	1.44E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.473	1.78E-186	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.425	2.72E-147	YER087W	AIM10	hom	Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.425	7.69E-147	YMR228W	MTF1	hom	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.420	1.36E-143	YMR193W	MRPL24	hom	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.416	1.52E-140	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.413	2.53E-137	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.412	1.42E-137	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.401	1.20E-129	YNL177C	MRPL22	hom	Mitochondrial ribosomal protein of the large subunit
0.397	1.58E-126	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.394	8.07E-125	YNL073W	MSK1	hom	Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)
0.393	4.34E-124	YPL078C	ATP4	hom	Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
0.392	1.16E-123	YGR171C	MSM1	hom	Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.392	1.70E-123	YGL064C	MRH4	hom	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.390	7.05E-122	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.390	8.47E-122	YDR296W	MHR1	hom	Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress