YCR075W-A_p

Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR075W-A / YCR075W-A

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.47|P-value:2.79E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.33|P-value:8.51E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:5.12|P-value:1.79E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.59|P-value:2.52E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:4.30|P-value:9.74E-6 ID:SGTC_263|Compound:alizarin|FD-Score:4.25|P-value:1.19E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.76|P-value:9.42E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.47|P-value:3.86E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:3.84|P-value:6.87E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.20|P-value:6.83E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.31|P-value:4.54E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.22|P-value:1.36E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:4.11|P-value:2.19E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:4.11|P-value:2.18E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.57|P-value:1.96E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.31|P-value:5.07E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.97|P-value:3.90E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:-3.50|P-value:2.25E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.11|P-value:9.11E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.33|P-value:8.38E-6 ID:SGTC_944|Compound:3370-0224|FD-Score:3.95|P-value:4.31E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:4.61|P-value:2.33E-6 ID:SGTC_1054|Compound:3429-0080|FD-Score:5.30|P-value:6.61E-8 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.22|P-value:6.93E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.58|P-value:1.91E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.60|P-value:1.74E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.73|P-value:1.05E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.49|P-value:2.62E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.90|P-value:5.39E-5 ID:SGTC_1734|Compound:st037168|FD-Score:3.39|P-value:3.74E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.11|P-value:2.19E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:9.87|P-value:4.34E-23 ID:SGTC_2003|Compound:4023581|FD-Score:-3.35|P-value:3.96E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.84|P-value:7.28E-7 ID:SGTC_2022|Compound:5136654|FD-Score:3.98|P-value:3.90E-5 ID:SGTC_2026|Compound:5148700|FD-Score:5.18|P-value:1.30E-7 ID:SGTC_2043|Compound:5101342|FD-Score:3.49|P-value:2.68E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.66|P-value:1.41E-4 ID:SGTC_2164|Compound:5685496|FD-Score:4.61|P-value:2.27E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.45|P-value:2.92E-8 ID:SGTC_2240|Compound:6690706|FD-Score:3.51|P-value:2.43E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.80|P-value:9.10E-7 ID:SGTC_2438|Compound:5259590|FD-Score:3.34|P-value:4.53E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.91|P-value:4.48E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.44|P-value:2.83E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.26|P-value:5.54E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.00|P-value:1.19E-9 ID:SGTC_2688|Compound:kanamycin b|FD-Score:14.20|P-value:4.63E-46 ID:SGTC_2693|Compound:st077581|FD-Score:4.59|P-value:2.48E-6 ID:SGTC_2696|Compound:st077691|FD-Score:3.40|P-value:3.63E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.37|P-value:4.09E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-4.11|P-value:1.93E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.11|P-value:9.16E-4 ID:SGTC_2909|Compound:7941780|FD-Score:4.42|P-value:5.54E-6 ID:SGTC_2912|Compound:7964298|FD-Score:4.02|P-value:3.24E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-3.97|P-value:3.60E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.50|P-value:2.50E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.65|P-value:1.43E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.21|P-value:6.51E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.91|P-value:4.44E-5 ID:SGTC_17|Compound:0960-0276|FD-Score:3.47|P-value:2.79E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.33|P-value:8.51E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:5.12|P-value:1.79E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.59|P-value:2.52E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:4.30|P-value:9.74E-6 ID:SGTC_263|Compound:alizarin|FD-Score:4.25|P-value:1.19E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.76|P-value:9.42E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.47|P-value:3.86E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:3.84|P-value:6.87E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.20|P-value:6.83E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.31|P-value:4.54E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.22|P-value:1.36E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:4.11|P-value:2.19E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:4.11|P-value:2.18E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.57|P-value:1.96E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.31|P-value:5.07E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.97|P-value:3.90E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:-3.50|P-value:2.25E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.11|P-value:9.11E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.33|P-value:8.38E-6 ID:SGTC_944|Compound:3370-0224|FD-Score:3.95|P-value:4.31E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:4.61|P-value:2.33E-6 ID:SGTC_1054|Compound:3429-0080|FD-Score:5.30|P-value:6.61E-8 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.22|P-value:6.93E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.58|P-value:1.91E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.60|P-value:1.74E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.73|P-value:1.05E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.49|P-value:2.62E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.90|P-value:5.39E-5 ID:SGTC_1734|Compound:st037168|FD-Score:3.39|P-value:3.74E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.11|P-value:2.19E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:9.87|P-value:4.34E-23 ID:SGTC_2003|Compound:4023581|FD-Score:-3.35|P-value:3.96E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.84|P-value:7.28E-7 ID:SGTC_2022|Compound:5136654|FD-Score:3.98|P-value:3.90E-5 ID:SGTC_2026|Compound:5148700|FD-Score:5.18|P-value:1.30E-7 ID:SGTC_2043|Compound:5101342|FD-Score:3.49|P-value:2.68E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.66|P-value:1.41E-4 ID:SGTC_2164|Compound:5685496|FD-Score:4.61|P-value:2.27E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.45|P-value:2.92E-8 ID:SGTC_2240|Compound:6690706|FD-Score:3.51|P-value:2.43E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.80|P-value:9.10E-7 ID:SGTC_2438|Compound:5259590|FD-Score:3.34|P-value:4.53E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.91|P-value:4.48E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.44|P-value:2.83E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.26|P-value:5.54E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.00|P-value:1.19E-9 ID:SGTC_2688|Compound:kanamycin b|FD-Score:14.20|P-value:4.63E-46 ID:SGTC_2693|Compound:st077581|FD-Score:4.59|P-value:2.48E-6 ID:SGTC_2696|Compound:st077691|FD-Score:3.40|P-value:3.63E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.37|P-value:4.09E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-4.11|P-value:1.93E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.11|P-value:9.16E-4 ID:SGTC_2909|Compound:7941780|FD-Score:4.42|P-value:5.54E-6 ID:SGTC_2912|Compound:7964298|FD-Score:4.02|P-value:3.24E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-3.97|P-value:3.60E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.50|P-value:2.50E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.65|P-value:1.43E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.21|P-value:6.51E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.91|P-value:4.44E-5

Top fitness defect scores for YCR075W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 14.20 96.7 µM 4.63E-46 calcium & mitochondrial duress 6 2.25E-46
2 SGTC_1844 rapamycin 9.87 4.0 nM 4.34E-23 39 2.93E-23
3 SGTC_2679 rapamycin 6.00 1.0 nM 1.19E-9 76 9.95E-10
4 SGTC_2232 chlorophetanol 5.45 41.5 µM 2.92E-8 TRP & mitochondrial translation 57 2.49E-8
5 SGTC_1054 3429-0080 5.30 167.0 µM 6.61E-8 12 5.68E-8
6 SGTC_2026 5148700 5.18 152.0 µM 1.30E-7 7 1.12E-7
7 SGTC_210 3551-0445 5.12 56.8 µM 1.79E-7 36 1.55E-7
8 SGTC_2012 4023501 4.84 200.0 µM 7.28E-7 16 6.37E-7
9 SGTC_2408 sulbentine 4.80 18.4 µM 9.10E-7 32 7.98E-7
10 SGTC_2164 5685496 4.61 200.0 µM 2.27E-6 13 2.00E-6
11 SGTC_949 1165-0505 4.61 146.0 µM 2.33E-6 10 2.05E-6
12 SGTC_2693 st077581 4.59 40.7 µM 2.48E-6 17 2.19E-6
13 SGTC_221 trifluoperazine 4.59 10.3 µM 2.52E-6 NEO1-PIK1 183 2.23E-6
14 SGTC_2909 7941780 4.42 10.5 µM 5.54E-6 12 4.92E-6
15 SGTC_939 1165-0479 4.33 45.3 µM 8.38E-6 17 7.47E-6
16 SGTC_87 0100-0052 4.33 35.5 µM 8.51E-6 84 7.59E-6
17 SGTC_236 1509-0011 4.30 5.3 µM 9.74E-6 364 8.70E-6
18 SGTC_263 alizarin 4.25 107.9 µM 1.19E-5 iron homeostasis 50 1.06E-5
19 SGTC_530 4358-1714 4.22 28.0 µM 1.36E-5 39 1.21E-5
20 SGTC_586 0957-0265 4.11 8.2 µM 2.18E-5 cell wall 41 1.95E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.367 2.22E-107 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.305 5.34E-73 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.282 1.59E-62 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.281 5.64E-62 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.274 1.07E-58 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.272 7.88E-58 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.261 3.61E-53 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.258 3.20E-52 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.255 6.01E-51 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.251 3.47E-49 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.245 3.53E-47 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.241 1.98E-45 YHR111W UBA4 hom Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p
0.238 1.74E-44 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.227 1.44E-40 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.227 1.46E-40 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)