YDL001W / RMD1

Cytoplasmic protein required for sporulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL001W / RMD1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.64|P-value:8.71E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:3.03|P-value:8.78E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.25|P-value:4.01E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.94|P-value:4.53E-10 ID:SGTC_135|Compound:0933-0004|FD-Score:3.49|P-value:1.59E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:8.57|P-value:4.69E-19 ID:SGTC_361|Compound:000s-0510|FD-Score:5.31|P-value:2.13E-8 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.38|P-value:3.21E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:3.64|P-value:8.72E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.28|P-value:3.60E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.72|P-value:6.37E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.81|P-value:4.17E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.21|P-value:4.64E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:13.10|P-value:1.02E-41 ID:SGTC_571|Compound:k831-0106|FD-Score:3.33|P-value:2.93E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.46|P-value:1.78E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.09|P-value:7.03E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.00|P-value:9.76E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.42|P-value:2.05E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.83|P-value:3.20E-7 ID:SGTC_924|Compound:2046-0044|FD-Score:3.43|P-value:1.98E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.90|P-value:2.85E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.19|P-value:4.89E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.39|P-value:2.97E-6 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.10|P-value:6.94E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.27|P-value:3.67E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.31|P-value:3.23E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.03|P-value:8.96E-4 ID:SGTC_1786|Compound:berberine|FD-Score:5.78|P-value:1.22E-9 ID:SGTC_1818|Compound:st052136|FD-Score:6.94|P-value:4.25E-13 ID:SGTC_1825|Compound:st052143|FD-Score:3.17|P-value:5.36E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.22|P-value:4.46E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.18|P-value:5.14E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.57|P-value:1.15E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.22|P-value:4.39E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.67|P-value:7.76E-5 ID:SGTC_2148|Compound:5546263|FD-Score:5.79|P-value:1.21E-9 ID:SGTC_2213|Compound:7173844|FD-Score:4.30|P-value:4.55E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:12.30|P-value:6.80E-37 ID:SGTC_2368|Compound:9071271|FD-Score:3.00|P-value:9.65E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.46|P-value:1.80E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.92|P-value:2.63E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.19|P-value:5.04E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:5.02|P-value:1.11E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.58|P-value:1.16E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-7.59|P-value:2.64E-15 ID:SGTC_2835|Compound:9006588|FD-Score:3.26|P-value:3.81E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.95|P-value:2.32E-5 ID:SGTC_2856|Compound:9022925|FD-Score:-3.20|P-value:5.01E-4 ID:SGTC_2857|Compound:9024691|FD-Score:5.72|P-value:1.82E-9 ID:SGTC_2859|Compound:9028643|FD-Score:-3.00|P-value:9.90E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.61|P-value:9.78E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.00|P-value:9.70E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.33|P-value:2.99E-4 ID:SGTC_3182|Compound:9108849|FD-Score:-3.17|P-value:5.50E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.13|P-value:9.97E-6 ID:SGTC_3329|Compound:9141233|FD-Score:3.75|P-value:5.55E-5 ID:SGTC_3339|Compound:9145883|FD-Score:4.04|P-value:1.55E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:3.64|P-value:8.71E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:3.03|P-value:8.78E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.25|P-value:4.01E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.94|P-value:4.53E-10 ID:SGTC_135|Compound:0933-0004|FD-Score:3.49|P-value:1.59E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:8.57|P-value:4.69E-19 ID:SGTC_361|Compound:000s-0510|FD-Score:5.31|P-value:2.13E-8 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.38|P-value:3.21E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:3.64|P-value:8.72E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.28|P-value:3.60E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.72|P-value:6.37E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.81|P-value:4.17E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.21|P-value:4.64E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:13.10|P-value:1.02E-41 ID:SGTC_571|Compound:k831-0106|FD-Score:3.33|P-value:2.93E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.46|P-value:1.78E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.09|P-value:7.03E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.00|P-value:9.76E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.42|P-value:2.05E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.83|P-value:3.20E-7 ID:SGTC_924|Compound:2046-0044|FD-Score:3.43|P-value:1.98E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.90|P-value:2.85E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.19|P-value:4.89E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.39|P-value:2.97E-6 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.10|P-value:6.94E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.27|P-value:3.67E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.31|P-value:3.23E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.03|P-value:8.96E-4 ID:SGTC_1786|Compound:berberine|FD-Score:5.78|P-value:1.22E-9 ID:SGTC_1818|Compound:st052136|FD-Score:6.94|P-value:4.25E-13 ID:SGTC_1825|Compound:st052143|FD-Score:3.17|P-value:5.36E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.22|P-value:4.46E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.18|P-value:5.14E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.57|P-value:1.15E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.22|P-value:4.39E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.67|P-value:7.76E-5 ID:SGTC_2148|Compound:5546263|FD-Score:5.79|P-value:1.21E-9 ID:SGTC_2213|Compound:7173844|FD-Score:4.30|P-value:4.55E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:12.30|P-value:6.80E-37 ID:SGTC_2368|Compound:9071271|FD-Score:3.00|P-value:9.65E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.46|P-value:1.80E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.92|P-value:2.63E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.19|P-value:5.04E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:5.02|P-value:1.11E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.58|P-value:1.16E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-7.59|P-value:2.64E-15 ID:SGTC_2835|Compound:9006588|FD-Score:3.26|P-value:3.81E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.95|P-value:2.32E-5 ID:SGTC_2856|Compound:9022925|FD-Score:-3.20|P-value:5.01E-4 ID:SGTC_2857|Compound:9024691|FD-Score:5.72|P-value:1.82E-9 ID:SGTC_2859|Compound:9028643|FD-Score:-3.00|P-value:9.90E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.61|P-value:9.78E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.00|P-value:9.70E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.33|P-value:2.99E-4 ID:SGTC_3182|Compound:9108849|FD-Score:-3.17|P-value:5.50E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.13|P-value:9.97E-6 ID:SGTC_3329|Compound:9141233|FD-Score:3.75|P-value:5.55E-5 ID:SGTC_3339|Compound:9145883|FD-Score:4.04|P-value:1.55E-5

Top fitness defect scores for YDL001W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_568 1193-0097 13.10 7.5 µM 1.02E-41 ERAD & cell cycle 8 2.29E-39
2 SGTC_2250 alverine citrate 12.30 130.0 µM 6.80E-37 2 7.99E-35
3 SGTC_312 4092-0653 8.57 6.8 µM 4.69E-19 ergosterol depletion effects on membrane 20 4.95E-18
4 SGTC_1818 st052136 6.94 56.3 µM 4.25E-13 NEO1-PIK1 8 2.02E-12
5 SGTC_117 lucigenin 5.94 22.1 µM 4.53E-10 redox potentiating 40 1.43E-9
6 SGTC_2148 5546263 5.79 113.6 µM 1.21E-9 5 3.62E-9
7 SGTC_1786 berberine 5.78 21.6 µM 1.22E-9 60S ribosome export 9 3.65E-9
8 SGTC_2857 9024691 5.72 58.4 µM 1.82E-9 4 5.31E-9
9 SGTC_361 000s-0510 5.31 1.4 µM 2.13E-8 12 5.40E-8
10 SGTC_2777 climbazole 5.02 1.5 µM 1.11E-7 iron homeostasis 21 2.55E-7
11 SGTC_905 2-aminofluorene 4.83 215.0 µM 3.20E-7 cell wall signaling 13 6.95E-7
12 SGTC_2778 tioconazole 4.58 65.1 nM 1.16E-6 ergosterol depletion effects on membrane 44 2.34E-6
13 SGTC_1184 1269-1718 4.39 139.0 µM 2.97E-6 18 5.66E-6
14 SGTC_2213 7173844 4.30 200.0 µM 4.55E-6 10 8.47E-6
15 SGTC_3197 9113331 4.13 49.5 µM 9.97E-6 28 1.78E-5
16 SGTC_3339 9145883 4.04 14.9 µM 1.55E-5 11 2.70E-5
17 SGTC_2850 9015429 3.95 58.4 µM 2.32E-5 12 3.94E-5
18 SGTC_2566 crystal violet carbinol 3.92 226.0 nM 2.63E-5 39 4.43E-5
19 SGTC_931 2812-0076 3.90 566.0 µM 2.85E-5 27 4.79E-5
20 SGTC_495 decylubiquinone 3.81 155.0 µM 4.17E-5 copper-dependent oxidative stress 25 6.85E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.241 1.06E-45 YGR135W PRE9 hom Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform
0.215 1.91E-36 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.194 9.34E-30 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.176 7.95E-25 YPR089W_p YPR089W_p hom Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p
0.174 3.19E-24 YLR083C EMP70 hom Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments
0.170 4.13E-23 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.169 7.77E-23 YFR048W RMD8 hom Cytosolic protein required for sporulation
0.169 7.92E-23 YIL002C INP51 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth
0.168 1.46E-22 YDR407C TRS120 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.166 4.28E-22 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.162 2.82E-21 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.160 9.77E-21 YOL134C_d YOL134C_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit
0.148 6.70E-18 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.144 4.49E-17 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.144 6.42E-17 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data