HIPHOP chemogenomics database

YDL004W / ATP16

Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated

Zygosity: Heterozygous strain

fixedexpanded
Profile for YDL004W / ATP16

Click on Significant Values for Screen Details

Top fitness defect scores for YDL004W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2013	4024628	11.90	200.0 µM	3.72E-32		1	7.86E-33	4.67
2	SGTC_236	1509-0011	9.41	5.3 µM	6.16E-21		3	2.53E-21	1.76
3	SGTC_3205	9113483	7.78	49.5 µM	6.45E-15		1	3.73E-15	2.73
4	SGTC_1923	st058458	6.86	19.1 µM	5.09E-12		2	3.44E-12	0.92
5	SGTC_971	1315-0384	5.72	26.7 µM	6.61E-9	cell wall signaling	2	5.25E-9	0.94
6	SGTC_2019	4016004	5.17	108.0 µM	1.38E-7		4	1.17E-7	0.22
7	SGTC_120	rhodamine 6G	4.56	52.3 µM	2.80E-6	mitochondrial processes	12	2.52E-6	0.05
8	SGTC_2346	9031566	4.55	143.8 µM	2.91E-6	Golgi	10	2.63E-6	0.71
9	SGTC_2763	lisinopril	4.33	49.3 µM	8.20E-6		1	7.55E-6	0.52
10	SGTC_1381	2324-0066	4.31	62.1 µM	8.90E-6		7	8.20E-6	0.05
11	SGTC_2761	levamisole	4.24	97.9 µM	1.19E-5		3	1.10E-5	0.61
12	SGTC_1469	k284-2957	4.04	126.0 µM	2.85E-5		12	2.69E-5	0.07
13	SGTC_498	2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)	3.95	150.0 µM	4.04E-5	Golgi	2	3.83E-5	0.16
14	SGTC_655	k060-0012	3.94	42.0 µM	4.37E-5		6	4.15E-5	0.09
15	SGTC_1744	st037937	3.88	38.9 µM	5.43E-5		8	5.18E-5	0.40
16	SGTC_1278	0874-0585	3.80	172.0 µM	7.57E-5		6	7.25E-5	0.03
17	SGTC_87	0100-0052	3.79	35.5 µM	7.70E-5		19	7.38E-5	0.02
18	SGTC_59	0330-0160	3.79	1.3 µM	7.88E-5		5	7.56E-5	0.08
19	SGTC_2663	amphotericin b	3.72	100.0 µM	1.04E-4		7	1.00E-4	0.12
20	SGTC_1245	0418-0076	3.65	17.2 µM	1.34E-4	ERG2	10	1.30E-4	0.05

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.227	2.64E-40	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.226	4.30E-40	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.221	1.76E-38	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.219	1.19E-37	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.208	5.67E-34	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.204	5.07E-33	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.204	6.26E-33	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.204	1.05E-32	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.201	4.56E-32	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.201	4.59E-32	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.196	2.19E-30	YKL109W	HAP4	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.195	4.71E-30	YER141W	COX15	hom	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.194	8.09E-30	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.193	2.33E-29	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.191	5.59E-29	YMR286W	MRPL33	hom	Mitochondrial ribosomal protein of the large subunit