YDL012C

Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL012C / YDL012C

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.28|P-value:9.23E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.07|P-value:2.33E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:2.80|P-value:6.04E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:2.73|P-value:7.86E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.95|P-value:3.22E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:2.87|P-value:4.60E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.41|P-value:4.12E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:2.68|P-value:9.64E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.17|P-value:1.68E-9 ID:SGTC_1111|Compound:tnp00062|FD-Score:2.82|P-value:5.65E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.54|P-value:2.73E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.58|P-value:2.20E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:2.76|P-value:6.95E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-2.74|P-value:9.16E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.35|P-value:5.54E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-3.05|P-value:2.55E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.08|P-value:1.90E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.15|P-value:8.70E-7 ID:SGTC_1779|Compound:st039427|FD-Score:2.95|P-value:3.26E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.71|P-value:9.16E-6 ID:SGTC_1915|Compound:st067105|FD-Score:-2.88|P-value:5.17E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.19|P-value:6.72E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.54|P-value:1.21E-10 ID:SGTC_1931|Compound:st074438|FD-Score:-4.76|P-value:2.70E-8 ID:SGTC_1933|Compound:st074711|FD-Score:-3.04|P-value:2.63E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-4.83|P-value:1.70E-8 ID:SGTC_1947|Compound:st076332|FD-Score:-3.01|P-value:2.98E-4 ID:SGTC_2080|Compound:5212524|FD-Score:2.77|P-value:6.79E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.36|P-value:5.21E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.54|P-value:2.18E-5 ID:SGTC_2371|Compound:9071574|FD-Score:2.95|P-value:3.26E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.44|P-value:3.64E-5 ID:SGTC_2374|Compound:9071832|FD-Score:2.90|P-value:4.02E-4 ID:SGTC_2375|Compound:9072683|FD-Score:2.87|P-value:4.59E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.40|P-value:5.39E-5 ID:SGTC_2382|Compound:9035899|FD-Score:-3.51|P-value:3.10E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.23|P-value:9.58E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:2.77|P-value:6.66E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.76|P-value:8.35E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:2.69|P-value:9.34E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-4.11|P-value:1.34E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-3.04|P-value:2.63E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.40|P-value:4.29E-5 ID:SGTC_2709|Compound:st078560|FD-Score:2.79|P-value:6.35E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.37|P-value:4.97E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:2.73|P-value:7.80E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.04|P-value:2.20E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-2.78|P-value:7.84E-4 ID:SGTC_2832|Compound:7992762|FD-Score:2.74|P-value:7.66E-4 ID:SGTC_2833|Compound:9001315|FD-Score:4.51|P-value:9.71E-8 ID:SGTC_2835|Compound:9006588|FD-Score:3.76|P-value:7.04E-6 ID:SGTC_2909|Compound:7941780|FD-Score:2.73|P-value:7.85E-4 ID:SGTC_2941|Compound:9056145|FD-Score:3.94|P-value:2.69E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-4.19|P-value:8.45E-7 ID:SGTC_2952|Compound:9073731|FD-Score:-5.92|P-value:6.35E-12 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.28|P-value:9.23E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.07|P-value:2.33E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:2.80|P-value:6.04E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:2.73|P-value:7.86E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.95|P-value:3.22E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:2.87|P-value:4.60E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.41|P-value:4.12E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:2.68|P-value:9.64E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.17|P-value:1.68E-9 ID:SGTC_1111|Compound:tnp00062|FD-Score:2.82|P-value:5.65E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.54|P-value:2.73E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.58|P-value:2.20E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:2.76|P-value:6.95E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-2.74|P-value:9.16E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.35|P-value:5.54E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-3.05|P-value:2.55E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.08|P-value:1.90E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.15|P-value:8.70E-7 ID:SGTC_1779|Compound:st039427|FD-Score:2.95|P-value:3.26E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.71|P-value:9.16E-6 ID:SGTC_1915|Compound:st067105|FD-Score:-2.88|P-value:5.17E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.19|P-value:6.72E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.54|P-value:1.21E-10 ID:SGTC_1931|Compound:st074438|FD-Score:-4.76|P-value:2.70E-8 ID:SGTC_1933|Compound:st074711|FD-Score:-3.04|P-value:2.63E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-4.83|P-value:1.70E-8 ID:SGTC_1947|Compound:st076332|FD-Score:-3.01|P-value:2.98E-4 ID:SGTC_2080|Compound:5212524|FD-Score:2.77|P-value:6.79E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.36|P-value:5.21E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.54|P-value:2.18E-5 ID:SGTC_2371|Compound:9071574|FD-Score:2.95|P-value:3.26E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.44|P-value:3.64E-5 ID:SGTC_2374|Compound:9071832|FD-Score:2.90|P-value:4.02E-4 ID:SGTC_2375|Compound:9072683|FD-Score:2.87|P-value:4.59E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.40|P-value:5.39E-5 ID:SGTC_2382|Compound:9035899|FD-Score:-3.51|P-value:3.10E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.23|P-value:9.58E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:2.77|P-value:6.66E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-2.76|P-value:8.35E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:2.69|P-value:9.34E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-4.11|P-value:1.34E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-3.04|P-value:2.63E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.40|P-value:4.29E-5 ID:SGTC_2709|Compound:st078560|FD-Score:2.79|P-value:6.35E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.37|P-value:4.97E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:2.73|P-value:7.80E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.04|P-value:2.20E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-2.78|P-value:7.84E-4 ID:SGTC_2832|Compound:7992762|FD-Score:2.74|P-value:7.66E-4 ID:SGTC_2833|Compound:9001315|FD-Score:4.51|P-value:9.71E-8 ID:SGTC_2835|Compound:9006588|FD-Score:3.76|P-value:7.04E-6 ID:SGTC_2909|Compound:7941780|FD-Score:2.73|P-value:7.85E-4 ID:SGTC_2941|Compound:9056145|FD-Score:3.94|P-value:2.69E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-4.19|P-value:8.45E-7 ID:SGTC_2952|Compound:9073731|FD-Score:-5.92|P-value:6.35E-12

Top fitness defect scores for YDL012C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2833 9001315 4.51 45.5 µM 9.71E-8 amide catabolism 36 3.18E-6
2 SGTC_1920 st075728 4.19 45.7 µM 6.72E-7 18 1.39E-5
3 SGTC_1716 st033144 4.15 30.6 µM 8.70E-7 16 1.70E-5
4 SGTC_2941 9056145 3.94 11.2 µM 2.69E-6 19 4.02E-5
5 SGTC_2835 9006588 3.76 71.4 µM 7.04E-6 47 8.41E-5
6 SGTC_1783 st039459 3.71 87.5 µM 9.16E-6 Golgi 28 1.03E-4
7 SGTC_2349 9023730 3.54 187.1 µM 2.18E-5 41 1.99E-4
8 SGTC_2373 9071805 3.44 200.0 µM 3.64E-5 26 2.96E-4
9 SGTC_1033 k072-0102 3.41 21.3 µM 4.12E-5 60S ribosome export 42 3.26E-4
10 SGTC_2703 st077852 3.40 53.4 µM 4.29E-5 45 3.36E-4
11 SGTC_2754 granisetron 3.37 64.0 µM 4.97E-5 53 3.76E-4
12 SGTC_2345 9052315 3.36 157.4 µM 5.21E-5 39 3.90E-4
13 SGTC_1380 2291-0730 3.35 164.0 µM 5.54E-5 50 4.09E-4
14 SGTC_2568 diosmetin 3.23 100.0 µM 9.58E-5 56 6.22E-4
15 SGTC_1713 st033146 3.08 12.8 µM 1.90E-4 69 0.00105
16 SGTC_2809 7964133 3.04 13.0 µM 2.20E-4 60S ribosome export 97 0.00118
17 SGTC_2371 9071574 2.95 200.0 µM 3.26E-4 46 0.00159
18 SGTC_1779 st039427 2.95 55.0 µM 3.26E-4 84 0.00159
19 SGTC_2374 9071832 2.90 200.0 µM 4.02E-4 endomembrane recycling 40 0.00187
20 SGTC_2375 9072683 2.87 200.0 µM 4.59E-4 mitochondrial processes 77 0.00207

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.195 5.15E-30 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.190 1.68E-28 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.184 4.97E-27 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.182 2.74E-26 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.176 1.03E-24 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.174 4.20E-24 YDR242W AMD2 hom Putative amidase
0.171 1.62E-23 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.167 1.92E-22 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.166 3.05E-22 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.162 3.11E-21 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.162 4.85E-21 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.160 1.48E-20 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.153 5.64E-19 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.151 1.50E-18 YDL039C PRM7 hom Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements
0.149 4.10E-18 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport