YDL023C_d

Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL023C / YDL023C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.77|P-value:1.62E-8 ID:SGTC_108|Compound:0509-0257|FD-Score:3.85|P-value:1.12E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.65|P-value:2.36E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.89|P-value:9.56E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:3.27|P-value:8.84E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:5.04|P-value:6.84E-7 ID:SGTC_377|Compound:3970-0964|FD-Score:5.31|P-value:1.77E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:11.30|P-value:1.32E-27 ID:SGTC_697|Compound:0508-1955|FD-Score:3.91|P-value:9.13E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:5.82|P-value:1.19E-8 ID:SGTC_778|Compound:3456-2434|FD-Score:4.84|P-value:1.77E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:3.33|P-value:7.06E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.27|P-value:8.78E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.59|P-value:2.73E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.50|P-value:4.00E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.33|P-value:1.79E-19 ID:SGTC_1687|Compound:st020778|FD-Score:5.75|P-value:1.75E-8 ID:SGTC_1712|Compound:st032288|FD-Score:3.55|P-value:3.40E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-3.26|P-value:8.38E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-3.32|P-value:6.83E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.69|P-value:1.90E-4 ID:SGTC_1800|Compound:st050079|FD-Score:6.06|P-value:3.14E-9 ID:SGTC_1801|Compound:st050089|FD-Score:4.84|P-value:1.73E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.72|P-value:3.08E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.27|P-value:8.84E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.60|P-value:2.59E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-4.16|P-value:3.11E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-4.38|P-value:1.22E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.76|P-value:1.61E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-4.41|P-value:1.07E-5 ID:SGTC_2281|Compound:7943571|FD-Score:3.33|P-value:7.27E-4 ID:SGTC_2338|Compound:7999974|FD-Score:4.10|P-value:4.31E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.71|P-value:1.87E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.42|P-value:4.84E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.55|P-value:3.32E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.38|P-value:5.97E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.25|P-value:9.24E-4 ID:SGTC_2643|Compound:anethole|FD-Score:-3.32|P-value:6.95E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.50|P-value:3.72E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-4.01|P-value:5.67E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.90|P-value:1.31E-6 ID:SGTC_2849|Compound:9019321|FD-Score:4.62|P-value:4.80E-6 ID:SGTC_2871|Compound:9038510|FD-Score:3.72|P-value:1.84E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-3.32|P-value:6.96E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.45|P-value:4.74E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-3.80|P-value:1.27E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-3.66|P-value:2.08E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.59|P-value:2.75E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.77|P-value:1.62E-8 ID:SGTC_108|Compound:0509-0257|FD-Score:3.85|P-value:1.12E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.65|P-value:2.36E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.89|P-value:9.56E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:3.27|P-value:8.84E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:5.04|P-value:6.84E-7 ID:SGTC_377|Compound:3970-0964|FD-Score:5.31|P-value:1.77E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:11.30|P-value:1.32E-27 ID:SGTC_697|Compound:0508-1955|FD-Score:3.91|P-value:9.13E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:5.82|P-value:1.19E-8 ID:SGTC_778|Compound:3456-2434|FD-Score:4.84|P-value:1.77E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:3.33|P-value:7.06E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.27|P-value:8.78E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.59|P-value:2.73E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.50|P-value:4.00E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.33|P-value:1.79E-19 ID:SGTC_1687|Compound:st020778|FD-Score:5.75|P-value:1.75E-8 ID:SGTC_1712|Compound:st032288|FD-Score:3.55|P-value:3.40E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-3.26|P-value:8.38E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-3.32|P-value:6.83E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.69|P-value:1.90E-4 ID:SGTC_1800|Compound:st050079|FD-Score:6.06|P-value:3.14E-9 ID:SGTC_1801|Compound:st050089|FD-Score:4.84|P-value:1.73E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.72|P-value:3.08E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.27|P-value:8.84E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.60|P-value:2.59E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-4.16|P-value:3.11E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-4.38|P-value:1.22E-5 ID:SGTC_2016|Compound:5121758|FD-Score:3.76|P-value:1.61E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-4.41|P-value:1.07E-5 ID:SGTC_2281|Compound:7943571|FD-Score:3.33|P-value:7.27E-4 ID:SGTC_2338|Compound:7999974|FD-Score:4.10|P-value:4.31E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.71|P-value:1.87E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.42|P-value:4.84E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.55|P-value:3.32E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.38|P-value:5.97E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.25|P-value:9.24E-4 ID:SGTC_2643|Compound:anethole|FD-Score:-3.32|P-value:6.95E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.50|P-value:3.72E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-4.01|P-value:5.67E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.90|P-value:1.31E-6 ID:SGTC_2849|Compound:9019321|FD-Score:4.62|P-value:4.80E-6 ID:SGTC_2871|Compound:9038510|FD-Score:3.72|P-value:1.84E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-3.32|P-value:6.96E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:3.45|P-value:4.74E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-3.80|P-value:1.27E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-3.66|P-value:2.08E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.59|P-value:2.75E-4

Top fitness defect scores for YDL023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_528 3492-0019 11.30 172.0 µM 1.32E-27 calcium & mitochondrial duress 36 8.29E-30
2 SGTC_1635 st007035 9.33 42.4 µM 1.79E-19 83 5.44E-21
3 SGTC_1800 st050079 6.06 29.1 µM 3.14E-9 NEO1-PIK1 38 6.88E-10
4 SGTC_769 0302-0231 5.82 76.0 µM 1.19E-8 9 2.92E-9
5 SGTC_58 0957-0393 5.77 9.0 µM 1.62E-8 cell wall 226 4.06E-9
6 SGTC_1687 st020778 5.75 55.4 µM 1.75E-8 114 4.41E-9
7 SGTC_377 3970-0964 5.31 33.1 µM 1.77E-7 21 5.42E-8
8 SGTC_309 k408-0051 5.04 1.5 µM 6.84E-7 26 2.34E-7
9 SGTC_2679 rapamycin 4.90 1.0 nM 1.31E-6 99 4.74E-7
10 SGTC_1801 st050089 4.84 28.4 µM 1.73E-6 NEO1-PIK1 82 6.41E-7
11 SGTC_778 3456-2434 4.84 196.0 µM 1.77E-6 mitochondrial response to ROS 50 6.57E-7
12 SGTC_1803 st050068 4.72 52.4 µM 3.08E-6 NEO1-PIK1 129 1.19E-6
13 SGTC_2849 9019321 4.62 13.0 µM 4.80E-6 21 1.93E-6
14 SGTC_2338 7999974 4.10 200.0 µM 4.31E-5 19 2.08E-5
15 SGTC_697 0508-1955 3.91 564.0 µM 9.13E-5 35 4.68E-5
16 SGTC_168 3970-0862 3.89 530.5 µM 9.56E-5 124 4.92E-5
17 SGTC_108 0509-0257 3.85 621.1 µM 1.12E-4 55 5.83E-5
18 SGTC_2016 5121758 3.76 140.0 µM 1.61E-4 redox potentiating 61 8.64E-5
19 SGTC_2871 9038510 3.72 13.0 µM 1.84E-4 28 9.98E-5
20 SGTC_2514 salinomycin 3.71 42.7 µM 1.87E-4 54 1.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.336 1.67E-89 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.312 8.11E-77 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.310 1.34E-75 YIL041W GVP36 hom BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis
0.283 1.14E-62 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.270 2.85E-57 YOR043W WHI2 hom Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
0.270 3.06E-57 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.249 9.53E-49 YIL065C FIS1 hom Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation
0.237 4.96E-44 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.223 5.82E-39 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.215 2.61E-36 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.214 3.16E-36 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.214 6.29E-36 YKR095W MLP1 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
0.212 1.43E-35 YIL098C FMC1 hom Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
0.210 1.17E-34 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.209 1.99E-34 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact