HIPHOP chemogenomics database
YDL026W_d 
Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YDL026W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.129 | 6.23E-14 | YOR268C_p | YOR268C_p | hom | Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene |
| 0.125 | 3.96E-13 | YGR179C | OKP1 | het | Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7 |
| 0.110 | 1.52E-10 | YHR149C | SKG6 | hom | Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p |
| 0.102 | 2.75E-9 | YGR082W | TOM20 | het | Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins |
| 0.101 | 5.16E-9 | YJL033W | HCA4 | het | DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis |
| 0.100 | 6.94E-9 | YDR271C_d | YDR271C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W |
| 0.097 | 1.76E-8 | YPL243W | SRP68 | het | Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress |
| 0.097 | 1.94E-8 | YDR104C | SPO71 | hom | Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains |
| 0.096 | 2.68E-8 | YLR251W | SYM1 | hom | Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17 |
| 0.094 | 4.84E-8 | YOR334W | MRS2 | hom | Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns |
| 0.093 | 6.29E-8 | YOL073C | YOL073C | hom | Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2 |
| 0.093 | 6.85E-8 | YDL096C_d | OPI6_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential |
| 0.093 | 6.82E-8 | YDR255C | RMD5 | hom | Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain |
| 0.093 | 7.31E-8 | YOL101C | IZH4 | hom | Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress |
| 0.092 | 8.91E-8 | YBR087W | RFC5 | het | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |