YDL030W / PRP9

Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL030W / PRP9

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.36|P-value:2.65E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.40|P-value:2.24E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.38|P-value:2.49E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.79|P-value:4.73E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.19|P-value:5.21E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.17|P-value:5.37E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.28|P-value:5.34E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:5.48|P-value:8.01E-9 ID:SGTC_572|Compound:0960-0087|FD-Score:3.57|P-value:1.18E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.46|P-value:1.80E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.73|P-value:5.94E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:3.34|P-value:2.87E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:-5.56|P-value:5.17E-9 ID:SGTC_729|Compound:4092-0585|FD-Score:-4.64|P-value:8.96E-7 ID:SGTC_873|Compound:0591-4978|FD-Score:3.65|P-value:8.44E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.09|P-value:7.47E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.34|P-value:2.83E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.72|P-value:6.37E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.15|P-value:9.27E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.00|P-value:9.99E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.72|P-value:6.21E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.22|P-value:6.85E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.66|P-value:7.92E-7 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.57|P-value:1.20E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.04|P-value:8.91E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:-3.55|P-value:1.29E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.83|P-value:4.09E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-3.59|P-value:1.10E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.59|P-value:1.08E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-4.43|P-value:2.59E-6 ID:SGTC_1750|Compound:st081859|FD-Score:-3.73|P-value:6.32E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.25|P-value:4.08E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.62|P-value:9.46E-5 ID:SGTC_1923|Compound:st058458|FD-Score:-3.06|P-value:8.21E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.17|P-value:5.36E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.36|P-value:2.67E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.21|P-value:7.14E-6 ID:SGTC_2086|Compound:5274770|FD-Score:3.67|P-value:7.68E-5 ID:SGTC_2168|Compound:5727979|FD-Score:3.36|P-value:2.70E-4 ID:SGTC_2219|Compound:9098279|FD-Score:-3.30|P-value:3.46E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.38|P-value:2.43E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.15|P-value:5.78E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.11|P-value:6.87E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:5.58|P-value:4.52E-9 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.26|P-value:3.90E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:5.01|P-value:1.25E-7 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.48|P-value:1.98E-6 ID:SGTC_2860|Compound:9025725|FD-Score:3.21|P-value:4.74E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.58|P-value:1.12E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.50|P-value:1.56E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.85|P-value:3.63E-5 ID:SGTC_3081|Compound:9117243|FD-Score:3.29|P-value:3.48E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.36|P-value:2.65E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.40|P-value:2.24E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.38|P-value:2.49E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.79|P-value:4.73E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.19|P-value:5.21E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:3.17|P-value:5.37E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.28|P-value:5.34E-6 ID:SGTC_520|Compound:3584-0023|FD-Score:5.48|P-value:8.01E-9 ID:SGTC_572|Compound:0960-0087|FD-Score:3.57|P-value:1.18E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.46|P-value:1.80E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.73|P-value:5.94E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:3.34|P-value:2.87E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:-5.56|P-value:5.17E-9 ID:SGTC_729|Compound:4092-0585|FD-Score:-4.64|P-value:8.96E-7 ID:SGTC_873|Compound:0591-4978|FD-Score:3.65|P-value:8.44E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.09|P-value:7.47E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.34|P-value:2.83E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.72|P-value:6.37E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:4.15|P-value:9.27E-6 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.00|P-value:9.99E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.72|P-value:6.21E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.22|P-value:6.85E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.66|P-value:7.92E-7 ID:SGTC_1166|Compound:k206-0078|FD-Score:-3.57|P-value:1.20E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.04|P-value:8.91E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:-3.55|P-value:1.29E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.83|P-value:4.09E-5 ID:SGTC_1739|Compound:st037196|FD-Score:-3.59|P-value:1.10E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.59|P-value:1.08E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-4.43|P-value:2.59E-6 ID:SGTC_1750|Compound:st081859|FD-Score:-3.73|P-value:6.32E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.25|P-value:4.08E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.62|P-value:9.46E-5 ID:SGTC_1923|Compound:st058458|FD-Score:-3.06|P-value:8.21E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.17|P-value:5.36E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.36|P-value:2.67E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.21|P-value:7.14E-6 ID:SGTC_2086|Compound:5274770|FD-Score:3.67|P-value:7.68E-5 ID:SGTC_2168|Compound:5727979|FD-Score:3.36|P-value:2.70E-4 ID:SGTC_2219|Compound:9098279|FD-Score:-3.30|P-value:3.46E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.38|P-value:2.43E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.15|P-value:5.78E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.11|P-value:6.87E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:5.58|P-value:4.52E-9 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.26|P-value:3.90E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:5.01|P-value:1.25E-7 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.48|P-value:1.98E-6 ID:SGTC_2860|Compound:9025725|FD-Score:3.21|P-value:4.74E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.58|P-value:1.12E-4 ID:SGTC_3050|Compound:9093513|FD-Score:-3.50|P-value:1.56E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.85|P-value:3.63E-5 ID:SGTC_3081|Compound:9117243|FD-Score:3.29|P-value:3.48E-4

Top fitness defect scores for YDL030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2510 benzyl isothiocyanate 5.58 8.3 µM 4.52E-9 9 1.22E-8 0.15
2 SGTC_520 3584-0023 5.48 682.0 µM 8.01E-9 6 2.09E-8 0.28
3 SGTC_2774 tamoxifen 5.01 10.9 µM 1.25E-7 4 2.79E-7 0.43
4 SGTC_1122 capsaicin 4.66 818.6 nM 7.92E-7 1 1.60E-6 0.53
5 SGTC_2779 methotrexate 4.48 400.0 µM 1.98E-6 14 3.80E-6 0.52
6 SGTC_1053 3366-3204 4.22 134.0 µM 6.85E-6 cell wall 6 1.23E-5 0.05
7 SGTC_2012 4023501 4.21 200.0 µM 7.14E-6 10 1.28E-5 0.28
8 SGTC_1027 k015-0025 4.15 8.7 µM 9.27E-6 3 1.63E-5 0.01
9 SGTC_3058 9093861 3.85 49.5 µM 3.63E-5 6 5.94E-5 0.52
10 SGTC_95 0471-0001 3.79 561.1 µM 4.73E-5 5 7.62E-5 0.17
11 SGTC_661 1304-0007 3.73 33.6 µM 5.94E-5 5 9.45E-5 0.07
12 SGTC_1045 1348-1485 3.72 165.0 µM 6.21E-5 5 9.86E-5 0.07
13 SGTC_944 3370-0224 3.72 231.0 µM 6.37E-5 6 1.01E-4 0.18
14 SGTC_2086 5274770 3.67 176.6 µM 7.68E-5 13 1.20E-4 0.01
15 SGTC_873 0591-4978 3.65 488.0 µM 8.44E-5 5 1.32E-4 0.13
16 SGTC_1841 st054148 3.62 70.0 µM 9.46E-5 5 1.47E-4 0.20
17 SGTC_1743 st037606 3.59 46.4 µM 1.08E-4 12 1.66E-4 0.08
18 SGTC_2881 9058953 3.58 52.0 µM 1.12E-4 9 1.72E-4 0.00
19 SGTC_572 0960-0087 3.57 17.7 µM 1.18E-4 14 1.80E-4 0.04
20 SGTC_583 1488-1091 3.46 88.9 µM 1.80E-4 9 2.70E-4 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 6.78E-20 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.121 2.22E-12 YOR215C AIM41 hom Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.101 4.69E-9 YLR177W_p YLR177W_p hom Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication
0.092 9.12E-8 YPL206C PGC1 hom Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs
0.087 4.52E-7 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.085 7.20E-7 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.081 2.62E-6 YLR415C_p YLR415C_p hom Putative protein of unknown function; YLR415C is not an essential gene
0.081 2.78E-6 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.080 3.18E-6 YOR156C NFI1 hom SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length
0.079 4.26E-6 YBR252W DUT1 het deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate
0.079 5.15E-6 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.077 7.05E-6 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.076 9.80E-6 YLR167W RPS31 het Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog
0.075 1.44E-5 YGR237C_p YGR237C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.074 1.85E-5 YDR070C FMP16 hom Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress