YDL039C / PRM7

Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL039C / PRM7

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.82|P-value:3.28E-7 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.59|P-value:9.94E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.41|P-value:2.07E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:4.09|P-value:1.23E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.71|P-value:6.08E-5 ID:SGTC_433|Compound:pimozide|FD-Score:-3.53|P-value:1.30E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.62|P-value:8.99E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:3.13|P-value:6.15E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.66|P-value:7.82E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:-3.79|P-value:4.37E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.18|P-value:4.93E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.63|P-value:9.18E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.52|P-value:1.45E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:3.83|P-value:3.83E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.36|P-value:2.52E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.25|P-value:3.96E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-4.13|P-value:9.74E-6 ID:SGTC_1915|Compound:st067105|FD-Score:-3.26|P-value:3.72E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.30|P-value:3.15E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.10|P-value:6.72E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.31|P-value:3.01E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-3.05|P-value:7.88E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.39|P-value:2.37E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.06|P-value:7.69E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.62|P-value:9.47E-5 ID:SGTC_2334|Compound:9017922|FD-Score:3.87|P-value:3.24E-5 ID:SGTC_2338|Compound:7999974|FD-Score:4.25|P-value:5.70E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.02|P-value:9.15E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-4.15|P-value:8.77E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.26|P-value:3.65E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.02|P-value:8.85E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.61|P-value:9.70E-5 ID:SGTC_2933|Compound:9026794|FD-Score:-3.00|P-value:9.57E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.14|P-value:5.78E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.34|P-value:2.88E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.69|P-value:6.74E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:4.82|P-value:3.28E-7 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.59|P-value:9.94E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.41|P-value:2.07E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:4.09|P-value:1.23E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.71|P-value:6.08E-5 ID:SGTC_433|Compound:pimozide|FD-Score:-3.53|P-value:1.30E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.62|P-value:8.99E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:3.13|P-value:6.15E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.66|P-value:7.82E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:-3.79|P-value:4.37E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.18|P-value:4.93E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:3.63|P-value:9.18E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.52|P-value:1.45E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:3.83|P-value:3.83E-5 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.36|P-value:2.52E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.25|P-value:3.96E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-4.13|P-value:9.74E-6 ID:SGTC_1915|Compound:st067105|FD-Score:-3.26|P-value:3.72E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.30|P-value:3.15E-4 ID:SGTC_2000|Compound:st075254|FD-Score:-3.10|P-value:6.72E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.31|P-value:3.01E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-3.05|P-value:7.88E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.39|P-value:2.37E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.06|P-value:7.69E-4 ID:SGTC_2333|Compound:9017922|FD-Score:3.62|P-value:9.47E-5 ID:SGTC_2334|Compound:9017922|FD-Score:3.87|P-value:3.24E-5 ID:SGTC_2338|Compound:7999974|FD-Score:4.25|P-value:5.70E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:3.02|P-value:9.15E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-4.15|P-value:8.77E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.26|P-value:3.65E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.02|P-value:8.85E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.61|P-value:9.70E-5 ID:SGTC_2933|Compound:9026794|FD-Score:-3.00|P-value:9.57E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.14|P-value:5.78E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.34|P-value:2.88E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.69|P-value:6.74E-5

Top fitness defect scores for YDL039C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_6 0844-0013 4.82 19.8 µM 3.28E-7 44 7.22E-7
2 SGTC_2338 7999974 4.25 200.0 µM 5.70E-6 14 1.06E-5
3 SGTC_385 1494-0393 4.09 12.4 µM 1.23E-5 18 2.18E-5
4 SGTC_2334 9017922 3.87 200.0 µM 3.24E-5 26 5.40E-5
5 SGTC_1123 mangostin 3.83 811.3 nM 3.83E-5 mitochondrial response to ROS 44 6.33E-5
6 SGTC_703 3875-0075 3.66 71.8 µM 7.82E-5 13 1.24E-4
7 SGTC_992 3909-8734 3.63 162.0 µM 9.18E-5 30 1.44E-4
8 SGTC_2333 9017922 3.62 200.0 µM 9.47E-5 37 1.48E-4
9 SGTC_2917 7979103 3.61 53.8 µM 9.70E-5 41 1.52E-4
10 SGTC_2117 5521686 3.39 200.0 µM 2.37E-4 29 3.52E-4
11 SGTC_2956 9076196 3.34 2.5 µM 2.88E-4 45 4.23E-4
12 SGTC_1380 2291-0730 3.25 164.0 µM 3.96E-4 51 5.71E-4
13 SGTC_693 4161-2696 3.13 114.0 µM 6.15E-4 25 8.65E-4
14 SGTC_2618 avocadyne 3.02 43.4 µM 9.15E-4 63 0.00126
15 SGTC_776 4476-4378 2.99 112.0 µM 0.00103 ERG2 61 0.00140
16 SGTC_827 3253-0474 2.97 693.0 µM 0.00110 63 0.00150
17 SGTC_373 0844-0104 2.91 25.9 µM 0.00134 ERAD & cell cycle 119 0.00179
18 SGTC_701 4424-0219 2.91 185.0 µM 0.00134 calcium & mitochondrial duress 59 0.00179
19 SGTC_828 2074-0507 2.90 139.0 µM 0.00138 RPP1 & pyrimidine depletion 72 0.00185
20 SGTC_1078 idebenone 2.81 36.1 µM 0.00187 Golgi 116 0.00246

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.216 1.18E-36 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.173 5.13E-24 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.166 4.27E-22 YEL016C NPP2 hom Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication
0.156 1.10E-19 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.151 1.50E-18 YDL012C YDL012C hom Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication
0.148 7.64E-18 YDR179C CSN9 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
0.148 7.72E-18 YDR379W RGA2 hom GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
0.148 8.39E-18 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.146 1.95E-17 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.143 6.91E-17 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.141 2.62E-16 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.139 7.03E-16 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.138 1.13E-15 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.137 1.98E-15 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.135 3.61E-15 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p