HIPHOP chemogenomics database

YDL041W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C

Zygosity: Homozygous strain

fixedexpanded
Profile for YDL041W / YDL041W

Click on Significant Values for Screen Details

Top fitness defect scores for YDL041W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_146	3448-8650	12.60	53.1 µM	2.86E-28	NEO1-PIK1	11	1.34E-36
2	SGTC_1844	rapamycin	10.40	4.0 nM	9.03E-20		36	1.90E-25
3	SGTC_1547	harmine	10.10	94.2 µM	5.21E-19	ergosterol biosynthesis	5	1.89E-24
4	SGTC_2307	7538926	9.67	6.3 µM	1.89E-17		2	2.10E-22
5	SGTC_1873	rapamycin	8.18	2.0 nM	5.38E-13		12	1.45E-16
6	SGTC_524	r073-0010	7.78	27.8 µM	6.39E-12		10	3.71E-15
7	SGTC_2824	7998404	6.96	52.0 µM	6.87E-10		2	1.69E-12
8	SGTC_1083	didemethylchlorpromazine sulfoxide	6.91	707.4 nM	8.89E-10	redox potentiating	17	2.37E-12
9	SGTC_2679	rapamycin	6.83	1.0 nM	1.40E-9		63	4.32E-12
10	SGTC_1750	st081859	6.75	2.4 µM	2.07E-9	endomembrane recycling	93	7.19E-12
11	SGTC_1286	0929-0070	6.34	131.0 µM	1.76E-8		3	1.18E-10
12	SGTC_488	nitrendipine	6.31	139.0 µM	2.01E-8		14	1.40E-10
13	SGTC_660	4031-1742	6.16	102.0 µM	4.20E-8	redox potentiating	10	3.68E-10
14	SGTC_481	bay k-8644	5.83	50.0 µM	1.96E-7		8	2.76E-9
15	SGTC_2779	methotrexate	5.81	400.0 µM	2.16E-7		13	3.13E-9
16	SGTC_528	3492-0019	5.71	172.0 µM	3.42E-7	calcium & mitochondrial duress	130	5.71E-9
17	SGTC_2615	purpurogallin-4-carboxylic acid	5.64	100.0 µM	4.72E-7	redox potentiating	28	8.68E-9
18	SGTC_2666	tannic acid	5.59	100.0 µM	5.77E-7	iron homeostasis	12	1.13E-8
19	SGTC_733	4069-0007	5.11	56.1 µM	4.46E-6	ERAD & cell cycle	53	1.63E-7
20	SGTC_805	3852-0218	5.00	479.0 µM	6.76E-6	ERAD & cell cycle	36	2.80E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.312	1.12E-76	YAL021C	CCR4	hom	Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
0.235	1.79E-43	YJR066W	TOR1	hom	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.233	1.53E-42	YGL212W	VAM7	hom	Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.233	2.15E-42	YHR004C	NEM1	hom	Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.229	4.77E-41	YDL077C	VAM6	hom	Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.215	2.91E-36	YHR012W	VPS29	hom	Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.212	1.99E-35	YHR186C	KOG1	het	Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.210	1.39E-34	YML062C	MFT1	hom	Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.207	5.67E-34	YJL154C	VPS35	hom	Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.207	5.73E-34	YLR025W	SNF7	hom	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.206	2.22E-33	YJL124C	LSM1	hom	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.206	2.37E-33	YLR268W	SEC22	hom	R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
0.204	1.00E-32	YPL065W	VPS28	hom	Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.202	2.78E-32	YKL203C	TOR2	het	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.193	1.62E-29	YJR102C	VPS25	hom	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome