YDL045W-A / MRP10

Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL045W-A / MRP10

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.79|P-value:3.30E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:5.77|P-value:3.55E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:3.99|P-value:3.10E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.76|P-value:3.67E-7 ID:SGTC_174|Compound:3553-0389|FD-Score:3.93|P-value:3.70E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.14|P-value:6.47E-8 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.44|P-value:1.61E-8 ID:SGTC_304|Compound:1310-0298|FD-Score:4.90|P-value:1.27E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:5.91|P-value:1.92E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.35|P-value:8.75E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.01|P-value:2.73E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.86|P-value:4.54E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:5.20|P-value:3.96E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.90|P-value:3.85E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-8.23|P-value:6.82E-13 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.71|P-value:6.99E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-3.84|P-value:4.64E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.94|P-value:3.62E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:6.28|P-value:3.49E-8 ID:SGTC_2158|Compound:5657123|FD-Score:-4.05|P-value:2.39E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.23|P-value:3.54E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.05|P-value:2.42E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.43|P-value:6.69E-5 ID:SGTC_2989|Compound:9073649|FD-Score:-4.48|P-value:5.71E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.15|P-value:1.71E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-3.60|P-value:9.52E-4 ID:SGTC_3212|Compound:9128307|FD-Score:5.46|P-value:1.39E-6 ID:SGTC_3219|Compound:9131112|FD-Score:-6.24|P-value:3.85E-8 ID:SGTC_3220|Compound:9131269|FD-Score:5.79|P-value:3.30E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:5.79|P-value:3.30E-7 ID:SGTC_63|Compound:0099-0242|FD-Score:5.77|P-value:3.55E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:3.99|P-value:3.10E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.76|P-value:3.67E-7 ID:SGTC_174|Compound:3553-0389|FD-Score:3.93|P-value:3.70E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.14|P-value:6.47E-8 ID:SGTC_275|Compound:trichlorophene|FD-Score:6.44|P-value:1.61E-8 ID:SGTC_304|Compound:1310-0298|FD-Score:4.90|P-value:1.27E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:5.91|P-value:1.92E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.35|P-value:8.75E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.01|P-value:2.73E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.86|P-value:4.54E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:5.20|P-value:3.96E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.90|P-value:3.85E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-8.23|P-value:6.82E-13 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.71|P-value:6.99E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-3.84|P-value:4.64E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.94|P-value:3.62E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:6.28|P-value:3.49E-8 ID:SGTC_2158|Compound:5657123|FD-Score:-4.05|P-value:2.39E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.23|P-value:3.54E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.05|P-value:2.42E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-4.43|P-value:6.69E-5 ID:SGTC_2989|Compound:9073649|FD-Score:-4.48|P-value:5.71E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.15|P-value:1.71E-4 ID:SGTC_3125|Compound:9127534|FD-Score:-3.60|P-value:9.52E-4 ID:SGTC_3212|Compound:9128307|FD-Score:5.46|P-value:1.39E-6 ID:SGTC_3219|Compound:9131112|FD-Score:-6.24|P-value:3.85E-8 ID:SGTC_3220|Compound:9131269|FD-Score:5.79|P-value:3.30E-7

Top fitness defect scores for YDL045W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_275 trichlorophene 6.44 5.7 µM 1.61E-8 mitochondrial stress 103 6.17E-11
2 SGTC_1247 0448-0043 6.28 5.8 µM 3.49E-8 ERG2 9 1.75E-10
3 SGTC_236 1509-0011 6.14 5.3 µM 6.47E-8 288 4.00E-10
4 SGTC_310 1273-0058 5.91 1.1 µM 1.92E-7 mitochondrial stress 146 1.72E-9
5 SGTC_3220 9131269 5.79 49.5 µM 3.30E-7 3 3.56E-9
6 SGTC_58 0957-0393 5.79 9.0 µM 3.30E-7 cell wall 224 3.56E-9
7 SGTC_63 0099-0242 5.77 26.7 µM 3.55E-7 mitochondrial stress 31 3.93E-9
8 SGTC_173 1273-0061 5.76 2.7 µM 3.67E-7 mitochondrial stress 116 4.10E-9
9 SGTC_3212 9128307 5.46 49.5 µM 1.39E-6 20 2.43E-8
10 SGTC_2232 chlorophetanol 5.23 41.5 µM 3.54E-6 TRP & mitochondrial translation 68 8.56E-8
11 SGTC_502 l-744,832 5.20 89.3 µM 3.96E-6 calcium & mitochondrial duress 16 9.92E-8
12 SGTC_304 1310-0298 4.90 97.0 µM 1.27E-5 cell wall 31 4.71E-7
13 SGTC_119 0121-0043 3.99 24.8 µM 3.10E-4 mitochondrial stress 107 3.35E-5
14 SGTC_1071 trifluoperazine 3.94 6.3 µM 3.62E-4 26 4.12E-5
15 SGTC_174 3553-0389 3.93 74.3 µM 3.70E-4 23 4.24E-5
16 SGTC_467 ro 31-8220 3.86 72.8 µM 4.54E-4 calcium & mitochondrial duress 82 5.57E-5
17 SGTC_2183 6420625 3.59 130.5 µM 0.00102 mitochondrial processes 74 1.64E-4
18 SGTC_138 0850-0259 3.57 40.9 µM 0.00110 cell wall 221 1.81E-4
19 SGTC_2250 alverine citrate 3.56 130.0 µM 0.00112 192 1.84E-4
20 SGTC_782 0083-0095 3.51 30.5 µM 0.00131 49 2.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.393 2.13E-124 YJL063C MRPL8 hom Mitochondrial ribosomal protein of the large subunit
0.362 1.76E-104 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.361 1.57E-103 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.359 1.76E-102 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.359 5.21E-102 YJR113C RSM7 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
0.357 4.93E-101 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.355 1.67E-99 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.349 1.65E-96 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.349 1.66E-96 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.347 2.22E-95 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.341 3.94E-92 YPL029W SUV3 hom ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron
0.341 4.75E-92 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.340 1.23E-91 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.338 2.35E-90 YLR439W MRPL4 hom Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
0.336 1.88E-89 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene