YDL049C / KNH1

Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL049C / KNH1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:8.36|P-value:1.85E-18 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.23|P-value:4.31E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.22|P-value:4.01E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:-3.05|P-value:8.17E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.96|P-value:1.88E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.15|P-value:5.86E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:-3.25|P-value:3.95E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.81|P-value:3.70E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:3.28|P-value:3.15E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:8.05|P-value:3.16E-17 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.40|P-value:2.68E-6 ID:SGTC_1244|Compound:0416-0015|FD-Score:2.97|P-value:9.89E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.25|P-value:3.54E-4 ID:SGTC_1753|Compound:st043925|FD-Score:5.08|P-value:6.50E-8 ID:SGTC_1755|Compound:st041960|FD-Score:3.51|P-value:1.29E-4 ID:SGTC_1756|Compound:st041558|FD-Score:4.07|P-value:1.13E-5 ID:SGTC_1763|Compound:st044482|FD-Score:3.05|P-value:7.34E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.40|P-value:2.01E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.31|P-value:2.86E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.38|P-value:2.13E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.14|P-value:6.00E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.60|P-value:2.85E-9 ID:SGTC_2591|Compound:skatole|FD-Score:3.94|P-value:2.09E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-3.24|P-value:4.20E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.29|P-value:3.03E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.84|P-value:3.18E-5 ID:SGTC_3149|Compound:9097855|FD-Score:-4.70|P-value:5.98E-7 ID:SGTC_3153|Compound:9100258|FD-Score:-4.75|P-value:4.50E-7 ID:SGTC_3156|Compound:9099931|FD-Score:6.87|P-value:4.88E-13 ID:SGTC_3218|Compound:9131285|FD-Score:5.01|P-value:9.34E-8 ID:SGTC_3221|Compound:9128209|FD-Score:4.64|P-value:7.07E-7 ID:SGTC_3223|Compound:9129970|FD-Score:3.79|P-value:3.95E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:8.36|P-value:1.85E-18 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.23|P-value:4.31E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:3.22|P-value:4.01E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:-3.05|P-value:8.17E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.96|P-value:1.88E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.15|P-value:5.86E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:-3.25|P-value:3.95E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.81|P-value:3.70E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:3.28|P-value:3.15E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:8.05|P-value:3.16E-17 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.40|P-value:2.68E-6 ID:SGTC_1244|Compound:0416-0015|FD-Score:2.97|P-value:9.89E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.25|P-value:3.54E-4 ID:SGTC_1753|Compound:st043925|FD-Score:5.08|P-value:6.50E-8 ID:SGTC_1755|Compound:st041960|FD-Score:3.51|P-value:1.29E-4 ID:SGTC_1756|Compound:st041558|FD-Score:4.07|P-value:1.13E-5 ID:SGTC_1763|Compound:st044482|FD-Score:3.05|P-value:7.34E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.40|P-value:2.01E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.31|P-value:2.86E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.38|P-value:2.13E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.14|P-value:6.00E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.60|P-value:2.85E-9 ID:SGTC_2591|Compound:skatole|FD-Score:3.94|P-value:2.09E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-3.24|P-value:4.20E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.29|P-value:3.03E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.84|P-value:3.18E-5 ID:SGTC_3149|Compound:9097855|FD-Score:-4.70|P-value:5.98E-7 ID:SGTC_3153|Compound:9100258|FD-Score:-4.75|P-value:4.50E-7 ID:SGTC_3156|Compound:9099931|FD-Score:6.87|P-value:4.88E-13 ID:SGTC_3218|Compound:9131285|FD-Score:5.01|P-value:9.34E-8 ID:SGTC_3221|Compound:9128209|FD-Score:4.64|P-value:7.07E-7 ID:SGTC_3223|Compound:9129970|FD-Score:3.79|P-value:3.95E-5

Top fitness defect scores for YDL049C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_6 0844-0013 8.36 19.8 µM 1.85E-18 1 3.03E-17
2 SGTC_1083 didemethylchlorpromazine sulfoxide 8.05 707.4 nM 3.16E-17 redox potentiating 13 4.24E-16
3 SGTC_3156 9099931 6.87 49.5 µM 4.88E-13 1 3.32E-12
4 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.60 3.7 µM 2.85E-9 17 1.05E-8
5 SGTC_1753 st043925 5.08 64.0 µM 6.50E-8 3 1.93E-7
6 SGTC_3218 9131285 5.01 49.5 µM 9.34E-8 endomembrane recycling 16 2.70E-7
7 SGTC_3221 9128209 4.64 49.5 µM 7.07E-7 6 1.77E-6
8 SGTC_1756 st041558 4.07 35.5 µM 1.13E-5 10 2.34E-5
9 SGTC_781 4335-2806 3.96 94.4 µM 1.88E-5 21 3.74E-5
10 SGTC_2591 skatole 3.94 100.0 µM 2.09E-5 29 4.13E-5
11 SGTC_3147 9097027 3.84 49.5 µM 3.18E-5 27 6.11E-5
12 SGTC_927 2425-1185 3.81 123.0 µM 3.70E-5 28 7.05E-5
13 SGTC_3223 9129970 3.79 49.5 µM 3.95E-5 24 7.48E-5
14 SGTC_1755 st041960 3.51 45.2 µM 1.29E-4 37 2.24E-4
15 SGTC_1880 MG-132 3.40 525.0 µM 2.01E-4 34 3.39E-4
16 SGTC_2301 7769476 3.38 200.0 µM 2.13E-4 33 3.60E-4
17 SGTC_2279 7948423 3.31 32.9 µM 2.86E-4 26 4.72E-4
18 SGTC_3015 9080845 3.29 49.5 µM 3.03E-4 26 4.98E-4
19 SGTC_929 2805-0021 3.28 398.0 µM 3.15E-4 30 5.17E-4
20 SGTC_1412 3909-8563 3.25 178.0 µM 3.54E-4 27 5.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.296 5.95E-69 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.240 4.10E-45 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.234 5.25E-43 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.227 1.72E-40 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.218 1.86E-37 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.215 2.03E-36 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.215 2.67E-36 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.209 2.48E-34 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.207 6.79E-34 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.204 6.02E-33 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.201 8.27E-32 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.195 4.71E-30 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.194 6.69E-30 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.186 1.92E-27 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.180 8.00E-26 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies