YDL051W / LHP1

RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL051W / LHP1

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:4.40|P-value:5.85E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:4.20|P-value:1.48E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:3.29|P-value:5.23E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.33|P-value:4.65E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.63|P-value:2.01E-6 ID:SGTC_575|Compound:k072-0246|FD-Score:3.25|P-value:6.16E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.52|P-value:2.28E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:5.53|P-value:1.83E-8 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.33|P-value:4.50E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.87|P-value:5.72E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.67|P-value:1.27E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.54|P-value:2.14E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.63|P-value:1.52E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.39|P-value:6.18E-6 ID:SGTC_1774|Compound:st048371|FD-Score:3.14|P-value:8.98E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.12|P-value:9.21E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.27|P-value:5.73E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.11|P-value:9.73E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.61|P-value:1.66E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.07|P-value:2.58E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.27|P-value:5.58E-4 ID:SGTC_2226|Compound:7298446|FD-Score:4.39|P-value:6.25E-6 ID:SGTC_2292|Compound:7671323|FD-Score:4.19|P-value:1.49E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.14|P-value:8.62E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.20|P-value:7.32E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.98|P-value:3.76E-5 ID:SGTC_2343|Compound:7990716|FD-Score:-3.91|P-value:4.82E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.28|P-value:5.47E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.57|P-value:1.90E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.98|P-value:3.56E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.28|P-value:5.45E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-3.76|P-value:8.76E-5 ID:SGTC_2717|Compound:st081029|FD-Score:4.18|P-value:1.61E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.34|P-value:4.36E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-5.00|P-value:3.18E-7 ID:SGTC_3023|Compound:9089636|FD-Score:-3.30|P-value:5.04E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.40|P-value:5.85E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:4.20|P-value:1.48E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:3.29|P-value:5.23E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.33|P-value:4.65E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.63|P-value:2.01E-6 ID:SGTC_575|Compound:k072-0246|FD-Score:3.25|P-value:6.16E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.52|P-value:2.28E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:5.53|P-value:1.83E-8 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.33|P-value:4.50E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.87|P-value:5.72E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.67|P-value:1.27E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.54|P-value:2.14E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.63|P-value:1.52E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.39|P-value:6.18E-6 ID:SGTC_1774|Compound:st048371|FD-Score:3.14|P-value:8.98E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.12|P-value:9.21E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.27|P-value:5.73E-4 ID:SGTC_1984|Compound:st072354|FD-Score:3.11|P-value:9.73E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.61|P-value:1.66E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.07|P-value:2.58E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.27|P-value:5.58E-4 ID:SGTC_2226|Compound:7298446|FD-Score:4.39|P-value:6.25E-6 ID:SGTC_2292|Compound:7671323|FD-Score:4.19|P-value:1.49E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.14|P-value:8.62E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.20|P-value:7.32E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.98|P-value:3.76E-5 ID:SGTC_2343|Compound:7990716|FD-Score:-3.91|P-value:4.82E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.28|P-value:5.47E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.57|P-value:1.90E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.98|P-value:3.56E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.28|P-value:5.45E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-3.76|P-value:8.76E-5 ID:SGTC_2717|Compound:st081029|FD-Score:4.18|P-value:1.61E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.34|P-value:4.36E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-5.00|P-value:3.18E-7 ID:SGTC_3023|Compound:9089636|FD-Score:-3.30|P-value:5.04E-4

Top fitness defect scores for YDL051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_953 1188-0045 5.53 9.7 µM 1.83E-8 60S ribosome export 3 1.60E-8
2 SGTC_236 1509-0011 4.63 5.3 µM 2.01E-6 351 1.83E-6
3 SGTC_87 0100-0052 4.40 35.5 µM 5.85E-6 80 5.35E-6
4 SGTC_1772 st048439 4.39 82.2 µM 6.18E-6 25 5.66E-6
5 SGTC_2226 7298446 4.39 200.0 µM 6.25E-6 3 5.73E-6
6 SGTC_178 4092-0806 4.20 87.5 µM 1.48E-5 ergosterol depletion effects on membrane 84 1.36E-5
7 SGTC_2292 7671323 4.19 168.1 µM 1.49E-5 RNA processing & uracil transport 25 1.38E-5
8 SGTC_2717 st081029 4.18 62.3 µM 1.61E-5 15 1.49E-5
9 SGTC_2050 5263056 4.07 171.0 µM 2.58E-5 fatty acid desaturase (OLE1) 39 2.39E-5
10 SGTC_2316 5844804 3.98 197.4 µM 3.76E-5 30 3.49E-5
11 SGTC_996 3970-0799 3.87 1.8 µM 5.72E-5 85 5.34E-5
12 SGTC_1074 carmofur 3.67 3.8 µM 1.27E-4 exosome 28 1.19E-4
13 SGTC_1652 st011932 3.63 78.0 µM 1.52E-4 RSC complex & mRNA processing 19 1.43E-4
14 SGTC_2003 4023581 3.61 200.0 µM 1.66E-4 cell wall signaling 42 1.56E-4
15 SGTC_2380 9035439 3.57 200.0 µM 1.90E-4 endomembrane recycling 40 1.78E-4
16 SGTC_1216 1165-0504 3.54 9.7 µM 2.14E-4 22 2.02E-4
17 SGTC_801 0866-0028 3.52 10.1 µM 2.28E-4 47 2.15E-4
18 SGTC_213 1246-0773 3.33 967.0 nM 4.65E-4 47 4.41E-4
19 SGTC_188 3229-0966 3.29 278.5 µM 5.23E-4 56 4.96E-4
20 SGTC_2344 7990960 3.28 77.0 µM 5.47E-4 48 5.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.183 1.11E-26 YBR197C YBR197C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication
0.171 2.30E-23 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.159 2.62E-20 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.158 3.73E-20 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.155 2.17E-19 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.153 4.61E-19 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.152 8.52E-19 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.150 2.12E-18 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.150 2.45E-18 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.149 4.15E-18 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.148 7.82E-18 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.146 2.09E-17 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.142 1.44E-16 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.141 2.77E-16 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.139 6.26E-16 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p