YDL061C / RPS29B

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL061C / RPS29B

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:5.81|P-value:1.04E-9 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.26|P-value:4.71E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.61|P-value:1.34E-6 ID:SGTC_371|Compound:0195-0006|FD-Score:3.66|P-value:7.60E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.94|P-value:1.75E-7 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.18|P-value:4.95E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.80|P-value:4.30E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:7.03|P-value:2.25E-13 ID:SGTC_830|Compound:4076-0286|FD-Score:5.33|P-value:1.94E-8 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.40|P-value:2.72E-6 ID:SGTC_1228|Compound:0124-0032|FD-Score:4.08|P-value:1.25E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.32|P-value:3.99E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.56|P-value:1.48E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.07|P-value:7.44E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.39|P-value:2.89E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:5.14|P-value:5.71E-8 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.83|P-value:3.81E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.66|P-value:7.69E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.05|P-value:7.86E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.75|P-value:5.22E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.72|P-value:7.68E-5 ID:SGTC_1567|Compound:st069303|FD-Score:4.15|P-value:8.96E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:-4.63|P-value:1.22E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.26|P-value:3.73E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.19|P-value:6.04E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.58|P-value:1.08E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.07|P-value:7.36E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.07|P-value:1.33E-5 ID:SGTC_1792|Compound:st045773|FD-Score:3.67|P-value:7.49E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.37|P-value:2.43E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.12|P-value:6.25E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.37|P-value:2.43E-4 ID:SGTC_2075|Compound:5212009|FD-Score:4.26|P-value:5.28E-6 ID:SGTC_2081|Compound:5214970|FD-Score:-4.79|P-value:5.38E-7 ID:SGTC_2082|Compound:5219693|FD-Score:3.48|P-value:1.57E-4 ID:SGTC_2275|Compound:7947463|FD-Score:-4.55|P-value:1.78E-6 ID:SGTC_2277|Compound:7947813|FD-Score:-4.55|P-value:1.78E-6 ID:SGTC_2336|Compound:9001819|FD-Score:4.97|P-value:1.42E-7 ID:SGTC_2394|Compound:5221648|FD-Score:-3.72|P-value:7.62E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.12|P-value:6.14E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.26|P-value:3.71E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.99|P-value:1.27E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.56|P-value:1.22E-6 ID:SGTC_2822|Compound:7994718|FD-Score:4.96|P-value:1.54E-7 ID:SGTC_2827|Compound:7993847|FD-Score:-3.77|P-value:6.26E-5 ID:SGTC_2832|Compound:7992762|FD-Score:3.62|P-value:9.10E-5 ID:SGTC_2835|Compound:9006588|FD-Score:3.35|P-value:2.67E-4 ID:SGTC_2907|Compound:7721985|FD-Score:4.04|P-value:1.50E-5 ID:SGTC_2938|Compound:9059746|FD-Score:-3.24|P-value:4.98E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.27|P-value:3.55E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.06|P-value:7.52E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.38|P-value:3.01E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.36|P-value:3.25E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.81|P-value:1.04E-9 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.26|P-value:4.71E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.61|P-value:1.34E-6 ID:SGTC_371|Compound:0195-0006|FD-Score:3.66|P-value:7.60E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.94|P-value:1.75E-7 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.18|P-value:4.95E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.80|P-value:4.30E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:7.03|P-value:2.25E-13 ID:SGTC_830|Compound:4076-0286|FD-Score:5.33|P-value:1.94E-8 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.40|P-value:2.72E-6 ID:SGTC_1228|Compound:0124-0032|FD-Score:4.08|P-value:1.25E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.32|P-value:3.99E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.56|P-value:1.48E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.07|P-value:7.44E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.39|P-value:2.89E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:5.14|P-value:5.71E-8 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.83|P-value:3.81E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.66|P-value:7.69E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.05|P-value:7.86E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.75|P-value:5.22E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:-3.72|P-value:7.68E-5 ID:SGTC_1567|Compound:st069303|FD-Score:4.15|P-value:8.96E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:-4.63|P-value:1.22E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.26|P-value:3.73E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.19|P-value:6.04E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.58|P-value:1.08E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.07|P-value:7.36E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.07|P-value:1.33E-5 ID:SGTC_1792|Compound:st045773|FD-Score:3.67|P-value:7.49E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.37|P-value:2.43E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.12|P-value:6.25E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.37|P-value:2.43E-4 ID:SGTC_2075|Compound:5212009|FD-Score:4.26|P-value:5.28E-6 ID:SGTC_2081|Compound:5214970|FD-Score:-4.79|P-value:5.38E-7 ID:SGTC_2082|Compound:5219693|FD-Score:3.48|P-value:1.57E-4 ID:SGTC_2275|Compound:7947463|FD-Score:-4.55|P-value:1.78E-6 ID:SGTC_2277|Compound:7947813|FD-Score:-4.55|P-value:1.78E-6 ID:SGTC_2336|Compound:9001819|FD-Score:4.97|P-value:1.42E-7 ID:SGTC_2394|Compound:5221648|FD-Score:-3.72|P-value:7.62E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.12|P-value:6.14E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.26|P-value:3.71E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.99|P-value:1.27E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.56|P-value:1.22E-6 ID:SGTC_2822|Compound:7994718|FD-Score:4.96|P-value:1.54E-7 ID:SGTC_2827|Compound:7993847|FD-Score:-3.77|P-value:6.26E-5 ID:SGTC_2832|Compound:7992762|FD-Score:3.62|P-value:9.10E-5 ID:SGTC_2835|Compound:9006588|FD-Score:3.35|P-value:2.67E-4 ID:SGTC_2907|Compound:7721985|FD-Score:4.04|P-value:1.50E-5 ID:SGTC_2938|Compound:9059746|FD-Score:-3.24|P-value:4.98E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.27|P-value:3.55E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.06|P-value:7.52E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.38|P-value:3.01E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.36|P-value:3.25E-4

Top fitness defect scores for YDL061C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_800 3448-7362 7.03 155.0 µM 2.25E-13 translation 25 1.04E-12
2 SGTC_118 0083-0097 5.81 135.3 µM 1.04E-9 translation 27 3.10E-9
3 SGTC_830 4076-0286 5.33 57.8 µM 1.94E-8 translation 25 4.95E-8
4 SGTC_1266 0828-0227 5.14 32.9 µM 5.71E-8 7 1.38E-7
5 SGTC_2596 sinensetin 4.99 100.0 µM 1.27E-7 12 2.94E-7
6 SGTC_2336 9001819 4.97 198.7 µM 1.42E-7 heme biosynthesis & mitochondrial translocase 19 3.26E-7
7 SGTC_2822 7994718 4.96 71.4 µM 1.54E-7 9 3.51E-7
8 SGTC_387 norethindrone acetate 4.94 66.7 µM 1.75E-7 3 3.98E-7
9 SGTC_2688 kanamycin b 4.56 96.7 µM 1.22E-6 calcium & mitochondrial duress 287 2.50E-6
10 SGTC_1150 3909-7983 4.40 10.9 µM 2.72E-6 15 5.34E-6
11 SGTC_1238 0333-0287 4.32 48.8 µM 3.99E-6 Golgi 16 7.68E-6
12 SGTC_2075 5212009 4.26 200.0 µM 5.28E-6 6 1.00E-5
13 SGTC_1567 st069303 4.15 68.4 µM 8.96E-6 mitochondrial processes 17 1.65E-5
14 SGTC_1228 0124-0032 4.08 52.5 µM 1.25E-5 12 2.25E-5
15 SGTC_1734 st037168 4.07 69.4 µM 1.33E-5 20 2.40E-5
16 SGTC_2907 7721985 4.04 69.9 µM 1.50E-5 18 2.68E-5
17 SGTC_1372 2752-0194 3.83 270.0 µM 3.81E-5 19 6.50E-5
18 SGTC_562 3772-2733 3.80 112.0 µM 4.30E-5 ERG2 86 7.28E-5
19 SGTC_1543 azetidyl-2-carboxylic acid 3.75 198.0 µM 5.22E-5 19 8.75E-5
20 SGTC_1792 st045773 3.67 43.6 µM 7.49E-5 37 1.23E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 7.32E-22 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.163 1.77E-21 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.161 6.80E-21 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.143 9.19E-17 YHR203C RPS4B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
0.138 1.22E-15 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.136 2.37E-15 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.133 9.90E-15 YOR235W_d IRC13_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
0.132 1.82E-14 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.131 2.60E-14 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.129 5.78E-14 YLR062C_d BUD28_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.128 1.01E-13 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.125 3.29E-13 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.124 5.83E-13 YLR287C-A RPS30A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication
0.119 4.62E-12 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.118 6.07E-12 YIL008W URM1 hom Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response