YDL063C / SYO1

Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL063C / SYO1

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.91|P-value:1.95E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.72|P-value:3.66E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.52|P-value:7.11E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:4.23|P-value:6.17E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:3.83|P-value:2.57E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-3.47|P-value:8.58E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-5.41|P-value:5.02E-7 ID:SGTC_541|Compound:4513-1321|FD-Score:-4.23|P-value:6.72E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.63|P-value:4.96E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.75|P-value:8.26E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.47|P-value:8.18E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.92|P-value:2.02E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.17|P-value:8.37E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.93|P-value:1.92E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.11|P-value:1.01E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.94|P-value:1.89E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.74|P-value:3.73E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.23|P-value:6.29E-5 ID:SGTC_2893|Compound:9048488|FD-Score:4.25|P-value:5.76E-5 ID:SGTC_3028|Compound:9087778|FD-Score:3.55|P-value:6.42E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.82|P-value:2.68E-4 ID:SGTC_3103|Compound:9120822|FD-Score:4.10|P-value:9.98E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.64|P-value:4.79E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.70|P-value:4.15E-4 ID:SGTC_3232|Compound:9132874|FD-Score:-3.98|P-value:1.63E-4 ID:SGTC_3243|Compound:9134147|FD-Score:3.66|P-value:4.52E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.49|P-value:7.80E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.91|P-value:1.95E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.72|P-value:3.66E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.52|P-value:7.11E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:4.23|P-value:6.17E-5 ID:SGTC_395|Compound:anisomycin|FD-Score:3.83|P-value:2.57E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-3.47|P-value:8.58E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-5.41|P-value:5.02E-7 ID:SGTC_541|Compound:4513-1321|FD-Score:-4.23|P-value:6.72E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.63|P-value:4.96E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.75|P-value:8.26E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.47|P-value:8.18E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.92|P-value:2.02E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-4.17|P-value:8.37E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.93|P-value:1.92E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.11|P-value:1.01E-4 ID:SGTC_2125|Compound:5246583|FD-Score:-3.94|P-value:1.89E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.74|P-value:3.73E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.23|P-value:6.29E-5 ID:SGTC_2893|Compound:9048488|FD-Score:4.25|P-value:5.76E-5 ID:SGTC_3028|Compound:9087778|FD-Score:3.55|P-value:6.42E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.82|P-value:2.68E-4 ID:SGTC_3103|Compound:9120822|FD-Score:4.10|P-value:9.98E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.64|P-value:4.79E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.70|P-value:4.15E-4 ID:SGTC_3232|Compound:9132874|FD-Score:-3.98|P-value:1.63E-4 ID:SGTC_3243|Compound:9134147|FD-Score:3.66|P-value:4.52E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.49|P-value:7.80E-4

Top fitness defect scores for YDL063C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1283 0922-0125 4.75 16.4 µM 8.26E-6 8 1.01E-6
2 SGTC_2893 9048488 4.25 26.0 µM 5.76E-5 fatty acid desaturase (OLE1) 18 1.06E-5
3 SGTC_322 k048-0136 4.23 19.3 µM 6.17E-5 RSC & ERG11 11 1.15E-5
4 SGTC_2688 kanamycin b 4.23 96.7 µM 6.29E-5 calcium & mitochondrial duress 332 1.18E-5
5 SGTC_3103 9120822 4.10 49.5 µM 9.98E-5 11 2.06E-5
6 SGTC_87 0100-0052 3.91 35.5 µM 1.95E-4 109 4.62E-5
7 SGTC_395 anisomycin 3.83 6.2 µM 2.57E-4 10 6.44E-5
8 SGTC_3052 9092717 3.82 49.5 µM 2.68E-4 33 6.76E-5
9 SGTC_101 0490-5701 3.72 117.5 µM 3.66E-4 16 9.83E-5
10 SGTC_3243 9134147 3.66 49.5 µM 4.52E-4 4 1.27E-4
11 SGTC_3109 9122853 3.64 49.5 µM 4.79E-4 12 1.36E-4
12 SGTC_1267 0828-0272 3.63 9.5 µM 4.96E-4 29 1.42E-4
13 SGTC_3028 9087778 3.55 49.5 µM 6.42E-4 25 1.94E-4
14 SGTC_220 paclitaxel 3.52 373.4 µM 7.11E-4 17 2.19E-4
15 SGTC_3255 9139072 3.49 49.5 µM 7.80E-4 28 2.45E-4
16 SGTC_1287 0971-0001 3.47 34.6 µM 8.18E-4 sphingolipid biosynthesis & PDR1 60 2.59E-4
17 SGTC_374 0880-0231 3.37 82.3 µM 0.00111 iron homeostasis 49 3.73E-4
18 SGTC_2624 nerol 3.36 100.0 µM 0.00115 22 3.89E-4
19 SGTC_965 1291-5240 3.32 308.0 µM 0.00128 54 4.45E-4
20 SGTC_1809 st050081 3.25 57.6 µM 0.00157 37 5.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 7.83E-23 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.167 2.23E-22 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.136 2.69E-15 YJL132W_p YJL132W_p hom Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene
0.135 3.87E-15 YDR517W GRH1 hom Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress
0.134 5.42E-15 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.133 1.08E-14 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.127 1.64E-13 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.126 2.78E-13 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.125 3.50E-13 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport
0.121 2.10E-12 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.117 1.24E-11 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.116 1.98E-11 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.116 2.00E-11 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.115 2.57E-11 YDL137W ARF2 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication
0.113 6.14E-11 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation