YDL070W / BDF2

Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL070W / BDF2

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.84|P-value:3.36E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:-3.03|P-value:8.38E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.02|P-value:8.56E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:6.30|P-value:2.98E-11 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.36|P-value:2.42E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.13|P-value:5.67E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.12|P-value:6.08E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.75|P-value:4.95E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.90|P-value:1.78E-7 ID:SGTC_545|Compound:4218-0007|FD-Score:3.50|P-value:1.41E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:4.11|P-value:1.01E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:3.76|P-value:4.70E-5 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.04|P-value:7.91E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.84|P-value:3.28E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.20|P-value:6.42E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.39|P-value:2.12E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-4.03|P-value:1.42E-5 ID:SGTC_1200|Compound:1643-0193|FD-Score:5.56|P-value:3.82E-9 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.91|P-value:2.47E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.52|P-value:1.30E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.38|P-value:2.27E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.25|P-value:5.04E-6 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.10|P-value:6.34E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.02|P-value:8.55E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.72|P-value:5.63E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.05|P-value:7.69E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.69|P-value:6.35E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.28|P-value:3.27E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.69|P-value:1.78E-9 ID:SGTC_1800|Compound:st050079|FD-Score:3.73|P-value:5.39E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.14|P-value:5.57E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.13|P-value:5.82E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-4.19|P-value:6.63E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-3.07|P-value:7.16E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.28|P-value:4.48E-6 ID:SGTC_2280|Compound:7785178|FD-Score:-3.34|P-value:2.61E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.43|P-value:1.86E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.04|P-value:8.10E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.37|P-value:2.31E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-3.99|P-value:1.71E-5 ID:SGTC_2480|Compound:5767542|FD-Score:-3.45|P-value:1.72E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.41|P-value:2.02E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.83|P-value:3.57E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.20|P-value:4.41E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.37|P-value:2.36E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-4.22|P-value:5.92E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-4.39|P-value:2.64E-6 ID:SGTC_2939|Compound:9044578|FD-Score:-3.94|P-value:2.17E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.13|P-value:5.77E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-4.84|P-value:2.52E-7 ID:SGTC_2972|Compound:9093619|FD-Score:-4.35|P-value:3.07E-6 ID:SGTC_3001|Compound:9076041|FD-Score:3.07|P-value:7.20E-4 ID:SGTC_3016|Compound:9080866|FD-Score:4.04|P-value:1.34E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.38|P-value:2.72E-6 ID:SGTC_3060|Compound:1327-0027|FD-Score:-3.32|P-value:2.83E-4 ID:SGTC_3083|Compound:9117465|FD-Score:7.20|P-value:3.89E-14 ID:SGTC_3087|Compound:9117406|FD-Score:3.81|P-value:3.86E-5 ID:SGTC_3090|Compound:9117696|FD-Score:7.27|P-value:2.12E-14 ID:SGTC_3112|Compound:9123419|FD-Score:3.16|P-value:5.14E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.37|P-value:2.31E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.51|P-value:1.33E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:3.84|P-value:3.36E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:-3.03|P-value:8.38E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.02|P-value:8.56E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:6.30|P-value:2.98E-11 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.36|P-value:2.42E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.13|P-value:5.67E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.12|P-value:6.08E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.75|P-value:4.95E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.90|P-value:1.78E-7 ID:SGTC_545|Compound:4218-0007|FD-Score:3.50|P-value:1.41E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:4.11|P-value:1.01E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:3.76|P-value:4.70E-5 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.04|P-value:7.91E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.84|P-value:3.28E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.20|P-value:6.42E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.39|P-value:2.12E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-4.03|P-value:1.42E-5 ID:SGTC_1200|Compound:1643-0193|FD-Score:5.56|P-value:3.82E-9 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.91|P-value:2.47E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.52|P-value:1.30E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-3.38|P-value:2.27E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.25|P-value:5.04E-6 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.10|P-value:6.34E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.02|P-value:8.55E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.72|P-value:5.63E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.05|P-value:7.69E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.69|P-value:6.35E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.28|P-value:3.27E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.69|P-value:1.78E-9 ID:SGTC_1800|Compound:st050079|FD-Score:3.73|P-value:5.39E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.14|P-value:5.57E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.13|P-value:5.82E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-4.19|P-value:6.63E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-3.07|P-value:7.16E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.28|P-value:4.48E-6 ID:SGTC_2280|Compound:7785178|FD-Score:-3.34|P-value:2.61E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.43|P-value:1.86E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.04|P-value:8.10E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.37|P-value:2.31E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-3.99|P-value:1.71E-5 ID:SGTC_2480|Compound:5767542|FD-Score:-3.45|P-value:1.72E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.41|P-value:2.02E-4 ID:SGTC_2591|Compound:skatole|FD-Score:-3.83|P-value:3.57E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.20|P-value:4.41E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.37|P-value:2.36E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-4.22|P-value:5.92E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-4.39|P-value:2.64E-6 ID:SGTC_2939|Compound:9044578|FD-Score:-3.94|P-value:2.17E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.13|P-value:5.77E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-4.84|P-value:2.52E-7 ID:SGTC_2972|Compound:9093619|FD-Score:-4.35|P-value:3.07E-6 ID:SGTC_3001|Compound:9076041|FD-Score:3.07|P-value:7.20E-4 ID:SGTC_3016|Compound:9080866|FD-Score:4.04|P-value:1.34E-5 ID:SGTC_3037|Compound:9091026|FD-Score:4.38|P-value:2.72E-6 ID:SGTC_3060|Compound:1327-0027|FD-Score:-3.32|P-value:2.83E-4 ID:SGTC_3083|Compound:9117465|FD-Score:7.20|P-value:3.89E-14 ID:SGTC_3087|Compound:9117406|FD-Score:3.81|P-value:3.86E-5 ID:SGTC_3090|Compound:9117696|FD-Score:7.27|P-value:2.12E-14 ID:SGTC_3112|Compound:9123419|FD-Score:3.16|P-value:5.14E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.37|P-value:2.31E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.51|P-value:1.33E-4

Top fitness defect scores for YDL070W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3090 9117696 7.27 49.5 µM 2.12E-14 2 1.74E-13
2 SGTC_3083 9117465 7.20 49.5 µM 3.89E-14 1 3.06E-13
3 SGTC_116 0155-0182 6.30 31.8 µM 2.98E-11 mitochondrial response to ROS 20 1.46E-10
4 SGTC_1754 st042065 5.69 16.1 µM 1.78E-9 NEO1-PIK1 104 6.51E-9
5 SGTC_1200 1643-0193 5.56 18.4 µM 3.82E-9 6 1.33E-8
6 SGTC_528 3492-0019 4.90 172.0 µM 1.78E-7 calcium & mitochondrial duress 158 4.72E-7
7 SGTC_3037 9091026 4.38 49.5 µM 2.72E-6 NEO1-PIK1 98 5.96E-6
8 SGTC_2035 5154463 4.28 94.6 µM 4.48E-6 9 9.47E-6
9 SGTC_1310 1188-0297 4.25 994.0 nM 5.04E-6 azole & statin 29 1.06E-5
10 SGTC_1011 4112-3381 4.20 17.4 µM 6.42E-6 33 1.33E-5
11 SGTC_558 k064-0027 4.11 21.3 µM 1.01E-5 DNA damage response 23 2.02E-5
12 SGTC_3016 9080866 4.04 49.5 µM 1.34E-5 24 2.62E-5
13 SGTC_1261 0712-0010 3.91 12.7 µM 2.47E-5 RNA processing & uracil transport 24 4.64E-5
14 SGTC_1007 4101-0031 3.84 70.0 µM 3.28E-5 21 6.05E-5
15 SGTC_3 0833-0587 3.84 95.6 µM 3.36E-5 redox potentiating 23 6.17E-5
16 SGTC_3087 9117406 3.81 49.5 µM 3.86E-5 20 7.04E-5
17 SGTC_574 1315-0397 3.76 40.0 µM 4.70E-5 41 8.44E-5
18 SGTC_221 trifluoperazine 3.75 10.3 µM 4.95E-5 NEO1-PIK1 222 8.86E-5
19 SGTC_1800 st050079 3.73 29.1 µM 5.39E-5 NEO1-PIK1 135 9.60E-5
20 SGTC_1522 st012842 3.72 45.6 µM 5.63E-5 RNA pol III & RNase P/MRP 35 9.99E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.203 1.96E-32 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.175 1.58E-24 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.171 2.11E-23 YKR095W MLP1 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
0.166 3.52E-22 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.158 4.69E-20 YGL043W DST1 hom General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress
0.149 4.32E-18 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.145 2.86E-17 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.142 1.22E-16 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.140 3.18E-16 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.139 5.47E-16 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.139 6.99E-16 YHL020C OPI1 hom Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance
0.138 1.14E-15 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.137 1.86E-15 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.135 3.93E-15 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.134 7.23E-15 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p