YDL071C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL071C / YDL071C

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.96|P-value:9.73E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.45|P-value:1.97E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:-5.53|P-value:1.06E-7 ID:SGTC_54|Compound:0159-0055|FD-Score:4.24|P-value:4.60E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.96|P-value:9.55E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.40|P-value:8.62E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.37|P-value:9.70E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.43|P-value:7.94E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.38|P-value:7.12E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.62|P-value:4.26E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.38|P-value:9.26E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.50|P-value:6.36E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.51|P-value:6.20E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.88|P-value:1.76E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.43|P-value:6.09E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-5.07|P-value:9.54E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.40|P-value:6.80E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.80|P-value:2.30E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.00|P-value:1.12E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.28|P-value:9.96E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.35|P-value:2.92E-5 ID:SGTC_1774|Compound:st048371|FD-Score:3.65|P-value:3.80E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.83|P-value:3.97E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.64|P-value:9.18E-6 ID:SGTC_1849|Compound:st056239|FD-Score:3.55|P-value:5.33E-4 ID:SGTC_1850|Compound:st056238|FD-Score:6.05|P-value:1.09E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:5.19|P-value:8.18E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.75|P-value:2.71E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.37|P-value:9.62E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.20|P-value:5.25E-5 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.41|P-value:8.59E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.31|P-value:3.47E-5 ID:SGTC_2695|Compound:st077686|FD-Score:4.64|P-value:8.95E-6 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.55|P-value:5.32E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.59|P-value:1.14E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.26|P-value:4.23E-5 ID:SGTC_2805|Compound:7950783|FD-Score:3.43|P-value:8.00E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.40|P-value:6.68E-4 ID:SGTC_2900|Compound:5328528|FD-Score:9.13|P-value:1.25E-17 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:5.36|P-value:3.62E-7 ID:SGTC_2910|Compound:7948405|FD-Score:-6.49|P-value:5.85E-10 ID:SGTC_2915|Compound:7971052|FD-Score:-5.58|P-value:8.31E-8 ID:SGTC_2916|Compound:7875993|FD-Score:-6.06|P-value:6.51E-9 ID:SGTC_3037|Compound:9091026|FD-Score:3.45|P-value:7.41E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.65|P-value:3.87E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.60|P-value:1.08E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.67|P-value:3.62E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.53|P-value:5.80E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.96|P-value:9.73E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:4.45|P-value:1.97E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:-5.53|P-value:1.06E-7 ID:SGTC_54|Compound:0159-0055|FD-Score:4.24|P-value:4.60E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.96|P-value:9.55E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.40|P-value:8.62E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.37|P-value:9.70E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.43|P-value:7.94E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.38|P-value:7.12E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.62|P-value:4.26E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.38|P-value:9.26E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.50|P-value:6.36E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.51|P-value:6.20E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.88|P-value:1.76E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.43|P-value:6.09E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-5.07|P-value:9.54E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.40|P-value:6.80E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.80|P-value:2.30E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.00|P-value:1.12E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.28|P-value:9.96E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.35|P-value:2.92E-5 ID:SGTC_1774|Compound:st048371|FD-Score:3.65|P-value:3.80E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.83|P-value:3.97E-6 ID:SGTC_1803|Compound:st050068|FD-Score:4.64|P-value:9.18E-6 ID:SGTC_1849|Compound:st056239|FD-Score:3.55|P-value:5.33E-4 ID:SGTC_1850|Compound:st056238|FD-Score:6.05|P-value:1.09E-8 ID:SGTC_2408|Compound:sulbentine|FD-Score:5.19|P-value:8.18E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.75|P-value:2.71E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.37|P-value:9.62E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.20|P-value:5.25E-5 ID:SGTC_2655|Compound:perillic acid|FD-Score:3.41|P-value:8.59E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.31|P-value:3.47E-5 ID:SGTC_2695|Compound:st077686|FD-Score:4.64|P-value:8.95E-6 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.55|P-value:5.32E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.59|P-value:1.14E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.26|P-value:4.23E-5 ID:SGTC_2805|Compound:7950783|FD-Score:3.43|P-value:8.00E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.40|P-value:6.68E-4 ID:SGTC_2900|Compound:5328528|FD-Score:9.13|P-value:1.25E-17 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:5.36|P-value:3.62E-7 ID:SGTC_2910|Compound:7948405|FD-Score:-6.49|P-value:5.85E-10 ID:SGTC_2915|Compound:7971052|FD-Score:-5.58|P-value:8.31E-8 ID:SGTC_2916|Compound:7875993|FD-Score:-6.06|P-value:6.51E-9 ID:SGTC_3037|Compound:9091026|FD-Score:3.45|P-value:7.41E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.65|P-value:3.87E-4 ID:SGTC_3087|Compound:9117406|FD-Score:4.60|P-value:1.08E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.67|P-value:3.62E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.53|P-value:5.80E-4

Top fitness defect scores for YDL071C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2900 5328528 9.13 85.3 µM 1.25E-17 Golgi 3 3.48E-20
2 SGTC_1850 st056238 6.05 17.0 µM 1.09E-8 RPP1 & pyrimidine depletion 4 7.39E-10
3 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 5.36 39.7 µM 3.62E-7 1 4.21E-8
4 SGTC_2408 sulbentine 5.19 18.4 µM 8.18E-7 29 1.08E-7
5 SGTC_1800 st050079 4.83 29.1 µM 3.97E-6 NEO1-PIK1 81 6.68E-7
6 SGTC_2695 st077686 4.64 52.0 µM 8.95E-6 20 1.71E-6
7 SGTC_1803 st050068 4.64 52.4 µM 9.18E-6 NEO1-PIK1 132 1.76E-6
8 SGTC_3087 9117406 4.60 49.5 µM 1.08E-5 8 2.13E-6
9 SGTC_2777 climbazole 4.59 1.5 µM 1.14E-5 iron homeostasis 28 2.26E-6
10 SGTC_36 0335-0881 4.45 14.2 µM 1.97E-5 ubiquinone biosynthesis & proteasome 99 4.26E-6
11 SGTC_1745 st081495 4.35 74.0 µM 2.92E-5 RNA processing & uracil transport 66 6.70E-6
12 SGTC_2688 kanamycin b 4.31 96.7 µM 3.47E-5 calcium & mitochondrial duress 321 8.17E-6
13 SGTC_2790 5423970 4.26 71.4 µM 4.23E-5 endomembrane recycling 56 1.03E-5
14 SGTC_54 0159-0055 4.24 9.0 µM 4.60E-5 ERG2 39 1.13E-5
15 SGTC_2575 plumbagin 4.20 510.0 nM 5.25E-5 superoxide 33 1.32E-5
16 SGTC_1342 1486-1464 4.00 234.0 µM 1.12E-4 14 3.16E-5
17 SGTC_1125 tnp00248 3.88 1.3 µM 1.76E-4 30 5.31E-5
18 SGTC_1257 0669-0121 3.80 16.0 µM 2.30E-4 33 7.26E-5
19 SGTC_2419 paclitaxel 3.75 166.5 µM 2.71E-4 50 8.74E-5
20 SGTC_3304 9125678 3.67 46.1 µM 3.62E-4 64 1.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.36E-11 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.114 3.44E-11 YJL216C IMA5 hom Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose
0.106 7.80E-10 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.104 1.46E-9 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.100 6.58E-9 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.100 7.23E-9 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 9.81E-9 YKL112W ABF1 het DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
0.097 1.70E-8 YJL179W PFD1 hom Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin
0.097 1.73E-8 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.097 1.80E-8 YDR524C-B_p YDR524C-B_p hom Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication
0.097 1.85E-8 YLR252W_d YLR252W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism
0.096 2.18E-8 YML106W URA5 hom Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication
0.096 2.41E-8 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.095 3.13E-8 YDL033C SLM3 hom tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
0.094 5.26E-8 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation